A5064183255- Mesenchymal stem cell research
- Chemokine receptors and signaling
- Tissue Engineering and Regenerative Medicine
- Hematopoietic Stem Cell Transplantation
- Platelet Disorders and Treatments
- Liver physiology and pathology
- Pluripotent Stem Cells Research
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Electrospun Nanofibers in Biomedical Applications
- Angiogenesis and VEGF in Cancer
- Cardiac Fibrosis and Remodeling
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Cell Adhesion Molecules Research
- HIV Research and Treatment
- Virus-based gene therapy research
- Cancer-related gene regulation
- Nuclear Receptors and Signaling
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
Jagiellonian University
2016-2025
John Paul II Hospital
2012-2022
Institute of Nuclear Physics, Polish Academy of Sciences
2014-2018
Collegium Medicum in Bydgoszcz
2018
Andrzej Frycz Modrzewski Krakow University
2018
Cracow University of Technology
2007-2017
University of Ferrara
2017
Czech Academy of Sciences, Institute of Physics
2017
Uniwersytecki Szpital Dziecięcy
2007-2017
Christ Hospital
2012
Comparison of intracoronary infusion bone marrow (BM)-derived unselected mononuclear cells (UNSEL) and selected CD34+CXCR4+ (SEL) in patients with acute myocardial infarction (AMI) reduced <40% left ventricular ejection fraction (LVEF). Two hundred were randomized to UNSEL (n = 80) or SEL BM the control (CTRL) group without cell treatment. Primary endpoint: change LVEF volumes measured by magnetic resonance imaging before 6 months after procedure. After months, increased 3% (P 0.01) treated...
Background— Adult stem cells can contribute to myocardial regeneration after ischemic injury. Bone marrow and skeletal muscles contain a population of CXCR4 + expressing genes specific for muscle progenitor that be mobilized into the peripheral blood. The aims study were (1) confirm presence early tissue-committed cardiac, muscle, endothelial markers in populations mononuclear blood (2) assess dynamics magnitude mobilization CD34 , CD117 c-met CD34/CD117 CD34/CXCR4 relation inflammatory...
The concept that bone marrow (BM)-derived cells participate in cardiac regeneration remains highly controversial and the identity of specific cell type(s) involved unknown. In this study, we report postnatal BM contains a mobile pool express early lineage markers (Nkx2.5/Csx, GATA-4, MEF2C). These are present significant amounts harvested from young mice but their abundance decreases with age; addition, responsiveness these to gradients motomorphogens SDF-1, HGF, LIF changes age. FACS...
Objective: Under some circumstances the HIV virus may infect cells that do not express receptors essential to HIV-entry. We hypothesized platelet- and megakaryocyte-derived microparticles (MP) could play a role in such infections. MP are circular membrane fragments shed from surface of eukaryotic cells. After adhesion target cells, transfer membrane-associated proteins these found peripheral blood (PMP) (MegaMP) highly CXCR4 this receptor platelets or megakaryocytes CXCR4-null Design: Since...
Abstract We found that the murine cell lines C2C12 and G7 derived from muscle satellite cells, which are essential for regeneration, express functional CXCR4 receptor on their surface specific ligand this receptor, α-chemokine stromal-derived factor 1 (SDF-1), is secreted in tissue. These responded to SDF-1 stimulation by chemotaxis, phosphorylation of mitogen-activated protein kinase (MAPK) p42/44 AKT serine-threonine kinase, calcium flux, confirming functionality receptor. Moreover,...
To better define the role HIV-related chemokine receptor-chemokine axes play in human hematopoiesis, we investigated function of CXCR4 and CCR5 receptors myeloid, T- B-lymphoid cell lines selected for expression these (CXCR4+, CXCR4+ CCR5+, CCR5+ lines). We evaluated phosphorylation MAPK p42/44, AKT, STAT proteins examined ability ligands (stromal-derived factor-1 [SDF-1] macrophage inflammatory protein-1β [MIP-1β]) to influence growth, apoptosis, adhesion, production vascular endothelial...
Organoids are becoming particularly popular in modeling diseases that difficult to reproduce animals, due anatomical differences the structure of a given organ. Thus, they bridge between vitro and vivo models. Human midbrain is one structures currently being intensively reproduced organoids for Parkinson’s disease (PD). Thanks three-dimensional (3D) architecture use induced pluripotent stem cells (iPSCs) differentiation into organoids, it has been possible recapitulate complicated network...
Heme oxygenase-1 (HMOX1) is a cytoprotective enzyme degrading heme to biliverdin, iron ions, and carbon monoxide, whose expression induced in response oxidative stress. Its overexpression has been suggested as strategy improving survival of transplanted muscle precursors.Here we demonstrated that HMOX1 inhibits differentiation myoblasts modulates miRNA processing: downregulates Lin28 DGCR8, lowers the total pool cellular miRNAs, specifically blocks induction myomirs. Genetic or...
Abstract Aims We evaluated the safety, feasibility and initial effects of therapy with muscle‐derived cells (MDCs) for women stress urinary incontinence (SUI). Methods MDCs were isolated from an upper‐arm muscle biopsy 16 SUI. Cells by enzymatic digestion expanded in vitro 8–10 weeks. A quantity 0.6–25 × 10 6 obtained injected transurethrally into urethral rhabdosphincter under local anesthesia. The placed circumferentially at 9, 12, 3 O'clock positions endoscopic guidance. Results results...