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Aleksandra Gawrylak

ORCID: 0009-0006-4982-7369
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About
Contact & Profiles
A5052152503
Research Areas
  • Autophagy in Disease and Therapy
  • Cancer, Hypoxia, and Metabolism
  • Sirtuins and Resveratrol in Medicine
  • Telomeres, Telomerase, and Senescence
  • Calcium signaling and nucleotide metabolism

University of Warsaw
 2023-2024

University of Ecology and Management in Warsaw
 2024

Narodowy Instytut Leków
 2023

College of Europe, Warsaw
 2023

 Hypoxia, but Not Normoxia, Reduces Effects of Resveratrol on Cisplatin Treatment in A2780 Ovarian Cancer Cells: A Challenge for Resveratrol Use in Anticancer Adjuvant Cisplatin Therapy
OPENALEX - Publications 
Agnieszka Synowiec Klaudia Brodaczewska Gabriel Wcisło Aleksandra Majewska Agata Borkowska and 12 more Aleksandra Filipiak-Duliban Aleksandra Gawrylak Kinga Wilkus Katarzyna Piwocka Agata Kominek Halina Waś Sławomir Lewicki Jacek Siewiera Cezary Szczylik Jolanta Szenajch Jacek Z. Kubiak Claudine Kiéda

Natural compounds, such as resveratrol (Res), are currently used adjuvants for anticancer therapies. To evaluate the effectiveness of Res treatment ovarian cancer (OC), we screened response various OC cell lines to combined with cisplatin (CisPt) and Res. We identified A2780 cells most synergistically responding, thus optimal further analysis. Because hypoxia is hallmark solid tumor microenvironment, compared effects alone in combination CisPt (pO2 = 1%) vs. normoxia 19%). Hypoxia caused an...

10.3390/ijms24065715 article EN International Journal of Molecular Sciences 2023-03-16
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