A5008802556- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Liver Diseases and Immunity
- Gastrointestinal disorders and treatments
- Hepatitis C virus research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Poisoning and overdose treatments
- Liver Disease and Transplantation
- Microscopic Colitis
- Inflammatory mediators and NSAID effects
- Neonatal Health and Biochemistry
- Diverticular Disease and Complications
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical Practices and Patient Outcomes
- Metastasis and carcinoma case studies
- Potassium and Related Disorders
- Eosinophilic Esophagitis
- Pancreatitis Pathology and Treatment
- Cancer Diagnosis and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Electroconvulsive Therapy Studies
Beirut Arab University
2025
Hospital General Universitario Morales Meseguer
2012-2021
Hospital Universitario Virgen de las Nieves
2016
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2016
Universidad de Málaga
2016
Complejo Hospitalario Universitario de Albacete
2016
Instituto de Investigación Biomédica de Málaga
2016
Universidad de Murcia
2007
Hospital General Universitario Santa María del Rosell
1993-2001
Increased age and female sex are suggested risk factors for drug-induced hepatotoxicity (DILI). We studied the influence of these variables on propensity to develop DILI, as well its clinical expression outcome. All cases DILI submitted Spanish Registry between April 1994 August 2007 were analyzed. Six hundred three (310 men; mean age, 54 years) showed a similar distribution, reaching two peaks in 40- 49-year-old 60- 69-year-old groups. No recorded 20- 29-year-old group. Patients aged ≥60...
Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis 843 patients with DILI enrolled into the Spanish Registry over 20-year time period.Cases were identified, diagnosed and followed prospectively. Clinical features, drug outcome data collected.A total patients, mean age 54 years (48% females), up 2018. Hepatocellular was associated younger (adjusted odds ratio [aOR] per year 0.983; 95%...
Introduction: Our objective was to assess the perception, attitudes, and experiences of Lebanese hospital pharmacists in everyday practice regarding drug shortage as well identify challenges propose solutions.
Abstract Background & Aims Several pharmaceutical compounds have been shown to exert inhibitory effects on the bile salt export pump ( BSEP ) encoded by ABCB11 gene. We analysed combined effect drug‐induced liver injury DILI development of 1331T>C polymorphism and presence specific chemical moieties, with known inhibiting properties, in causative drug. Methods Genotyping using a TaqMan 5′ allelic discrimination assay was performed 188 S panish patients, 219 healthy controls 91 sex‐,...
Positive autoantibody (AAB) titres are commonly encountered in autoimmune hepatitis (AIH) and a proportion of drug-induced liver injury (DILI) patients. The underlying mechanism for selective AAB occurrence DILI is unknown, but could be associated with variations immune-associated genes. Hence, we aimed to analyse human leucocyte antigen (HLA) allele compositions positive (+) negative (-) AIH patients.High-resolution genotyping HLA class I (A, B, C) II (DRB1, DQB1) loci was performed on 207...
Older patients with hepatotoxicity have been scarcely studied in idiosyncratic drug‐induced liver injury (DILI) cohorts. We sought the distinctive characteristics of DILI older across age groups. A total 882 included Spanish Registry (33% ≥ 65 years) were categorized according to age: “young” (< years); “young‐old” (65–74 “middle‐old” (75–84 and “oldest‐old” (≥ 85 years). All elderly groups had an increasingly higher comorbidity burden ( P < 0.001) polypharmacy 0.001). There was a...
Aim: to evaluate the utility of double-balloon enteroscopy for small-bowel disease.Design: a prospective study 50 consecutive enteroscopies performed from December 2004 July 2005 analyze diagnoses and treatments.Patients: 44 patients (33 had undergone previous capsule endoscopy) with indications obscure digestive hemorrhage, angiodysplasia, Peutz-Jeghers syndrome, ulcer, suspected Crohn´s disease, tumors, refractory celiac disease.Results: we carried out studies in by oral route and, 6...
Capsule endoscopy and double balloon enteroscopy are well-recognized procedures in obscure gastrointestinal bleeding, with many factors that may influence their diagnosis yield. The aim of the present study was to characterize degree agreement between both techniques focus on type lesion a large cohort patients at referral center.One thousand two hundred nine capsules were administered 1,078 381 enteroscopies performed 361 obscure-gastrointestinal bleeding from 2004 2014.Both carried out 332...
Background and Aims Flawed ABC transporter functions may contribute to increased risk of drug-induced liver injury (DILI). We aimed analyse the influence genetic variations in transporters on DILI development clinical presentations a large Spanish cohort. Methods A total ten polymorphisms ABCB1 (1236T>C, 2677G>T,A, 3435T>C), ABCB4 (1954A>G) ABCC2 (−1774G>del, −1549A>G, −24C>T, 1249G>A, 3972C>T 4544G>A) were genotyped using Taqman 5′ allelic discrimination assays or sequencing 141 patients...
Natural killer cells are an integral part of the immune system and represent a large proportion lymphocyte population in liver. The activity these is regulated by various cell surface receptors, such as Ig-like receptors (KIR) that bind to human leukocyte antigen (HLA) class I ligands on target cell. composition KIR has been suggested influence development specific diseases, particularly autoimmune cancer reproductive diseases. role played idiosyncratic drug-induced liver injury (DILI)...