A5103039394- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Neutropenia and Cancer Infections
- COVID-19 and healthcare impacts
- Hematological disorders and diagnostics
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Head and Neck Cancer Studies
- Genetic factors in colorectal cancer
- Cancer Treatment and Pharmacology
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Colorectal and Anal Carcinomas
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Esophageal Cancer Research and Treatment
- Chronic Lymphocytic Leukemia Research
- Gastrointestinal Tumor Research and Treatment
- Cancer therapeutics and mechanisms
- Ear and Head Tumors
- Advanced Breast Cancer Therapies
Hospital Universitario Severo Ochoa
2013-2025
Hospital de León
2006-2024
New York University
2024
University Hospital Complex Of Vigo
2023
Complexo Hospitalario Universitario A Coruña
2023
Universidad Alfonso X el Sabio
2021
Hospital General Universitario Morales Meseguer
2002-2019
McMaster University
2019
Texas Cardiac Arrhythmia
2017
Western General Hospital
2014
Patients with cancer may be at increased risk of more severe COVID-19 disease; however, prognostic factors are not yet clearly identified. The GRAVID study aimed to describe clinical characteristics, outcomes, and predictors poor outcome in patients lung COVID-19.Prospective observational that included medical records PCR-confirmed diagnosis across 65 Spanish hospitals. primary endpoint was all-cause mortality; secondary endpoints were hospitalization admission intensive care units (ICU).A...
Abstract BACKGROUND Cancer patients with fever and neutropenia currently are assessed on clinical grounds only. The current study prospectively evaluated the efficacy of baseline procalcitonin (PCT) in detection bacteremia prediction outcome solid tumors febrile neutropenia. METHODS PCT levels were determined at every 48 hours 104 undergoing chemotherapy who developed (axillary temperature > 38 °C 2 occasions or 38.3 a single record) (absolute neutrophil count < 500 cells/μL). RESULTS...
A dose-escalation, phase I study evaluated the safety, pharmacokinetics, and efficacy of a weekly 1-h regimen kahalalide F, cyclic depsipeptide isolated from marine mollusk Elysia rufescens, in adult patients with advanced solid tumors no standard treatment available.Patients received an i.v. infusion F once until disease progression or unacceptable toxicity. The starting dose was 266 microg/m(2), escalation proceeded based on worst toxicity found previous cohort.Thirty-eight were enrolled...
Hyperglycaemia is an early and frequent adverse event during alpelisib treatment. METALLICA aimed to evaluate prophylactic metformin prevent or reduce hyperglycaemia occurrence in patients with HR+/HER2-/
BackgroundImmunotherapy-based treatments have demonstrated high efficacy in patients with advanced and locally non-small-cell lung cancer (NSCLC). BRAF mutations affect a small but significant fraction of NSCLC. The these therapies this subgroup is unknown.Materials methodsPlasma tissue samples from 116 resectable stage IIIA/B NSCLC patients, included NADIM II clinical trials (NADIM cohort), prospective academic cohort 84 IV (BLI-O were analyzed by next-generation sequencing.ResultsThe...
The functional morphology of the alimentary canal Marinogammarus obtusatus Dahl is described, with particular reference to proventriculus and digestive gland. a device (1) for mastication food, (2) retaining it while being broken up acted upon by enzymes (3) in which provision must be made convey forward into cardiac region digested food backwards Finally, there valvular direct undigested past ducts leading gland intestine. M. obtusutw. compared that mysids isopods concluded modifications...
The diet of two intertidal species gammarid, Marinogammarus obtusatus Dahl and M. pirloti Sexton Spooner is described. Both feed largely, but not exclusively, on decaying algae, may eat some living algae and, more rarely, carrion. Their feeding activities are influenced by the rhythmic pattern tidal ebb flow, only when covered water. When immersed incoming tide they ingest food rapidly for a while then intermittently, ingesting small amounts at time until uncovered once receding tide. They...
Several platforms for noninvasive EGFR testing are currently used in the clinical setting with sensitivities ranging from 30% to 100%. Prospective studies evaluating agreement and sources discordant results remain lacking. Herein, seven methodologies including two next-generation sequencing (NGS)-based methods, three high-sensitivity PCR-based platforms, FDA-approved methods were compared using 72 plasma samples, EGFR-mutant non-small-cell lung cancer (NSCLC) patients progressing on a...
Aim: to evaluate the utility of double-balloon enteroscopy for small-bowel disease.Design: a prospective study 50 consecutive enteroscopies performed from December 2004 July 2005 analyze diagnoses and treatments.Patients: 44 patients (33 had undergone previous capsule endoscopy) with indications obscure digestive hemorrhage, angiodysplasia, Peutz-Jeghers syndrome, ulcer, suspected Crohn´s disease, tumors, refractory celiac disease.Results: we carried out studies in by oral route and, 6...
The structure and formation of the cuticle Gammarus pulex L. is described found to be basically similar that decapod Crustacea. A scheme for designating stages in moulting cycle given. principal food reserve lipoid which stored digestive gland extensive adipose connective tissue. Glycogen only slight quantities, if at all, intermoult animals, but appears tissues, muscle sarcoplasm epidermis during pre‐moult. During pre‐moult forms an additional site storing lipoid, also epidermis. Following...
Docetaxel and erlotinib are registered second-line treatments for wild-type EGFR NSCLC. Previous studies suggested a predictive value of the VeriStrat test in therapy NSCLC, classifying patients as either good or poor. EMPHASIS-lung aimed at exploring this effect with squamous cell The trial closed prematurely because low accrual results from other trials. Our analysis includes an exploratory combined PROSE trial.EMPHASIS-lung was randomized phase III multicenter differential versus...
Background: Approximately 15% of patients infected by SARS-CoV-2 develop a distress syndrome secondary to host hyperinflammatory response induced cytokine storm. Myelosuppression is associated with higher risk infections and mortality. There are data support methods management for neutropenia COVID-19. We present multicenter experience during the first COVID-19 outbreak in neutropenic cancer SARS-CoV-2. Methods: Clinical retrospective were collected from Comorbidities, tumor type, stage,...
6001 Background: CetRT has not been compared with CRT after ICT in phase III. Objective: To compare the impact on overall survival of vs. a Phase III randomized controlled clinical trial non-inferiority design to CRT. Response Rate (RR), loco-regional control (LRC) and toxicity both arms were considered secondary objectives. Methods: Pts LAUHNC, ECOG 0-1, 18-72 years old, measurable disease, adequate renal liver function, received standard DCF G-CSF. After at least 2 cycles (range 2-3), pts...
Patients with lung cancer are at increased risk of SARS-CoV-2 infection and severe complications from COVID-19, but information on the efficacy anti-SARS-CoV-2 vaccine in these patients is scarce. We aimed evaluating safety immunogenicity COVID-19 vaccines this population.The prospective, nationwide SOLID substudy, enrolled adults who were fully vaccinated against COVID-19. Serum IgG antibody levels quantitatively assessed two weeks six months after receipt last dose using a chemiluminescent...
The combination of cisplatin and capecitabine was evaluated in patients with recurrent or unresectable squamous cell carcinoma the head neck (HNSCC), outcome parameters were correlated expression thymidine phosphorylase (TP), thymidilate syntetase (TS), vascular endothelial growth factor receptor (VEGFR) 1–3, microvessel density (MVD). Patients HNSCC eligible if they had received prior neoadjuvant chemotherapy, concurrent chemo-radiotherapy, no systemic therapy. (75 mg m−2 day 1), (2000...