A5079516794- Autoimmune Neurological Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Cancer, Hypoxia, and Metabolism
- Genetics and Neurodevelopmental Disorders
- Peripheral Neuropathies and Disorders
- Adipose Tissue and Metabolism
- RNA regulation and disease
- Microbial Metabolic Engineering and Bioproduction
- Lung Cancer Treatments and Mutations
- Neuroinflammation and Neurodegeneration Mechanisms
- Cellular transport and secretion
- Herpesvirus Infections and Treatments
- NF-κB Signaling Pathways
- Cardiac, Anesthesia and Surgical Outcomes
- Alzheimer's disease research and treatments
- Breast Cancer Treatment Studies
- Metabolism, Diabetes, and Cancer
- Nerve injury and regeneration
- Infectious Encephalopathies and Encephalitis
- Pancreatic and Hepatic Oncology Research
- Breast Lesions and Carcinomas
- Mitochondrial Function and Pathology
- Cardiac Arrhythmias and Treatments
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2011-2025
Fundació Clínic per a la Recerca Biomèdica
2005-2025
Universitat de Barcelona
2011-2025
Institut d'Investigació Biomèdica de Girona
2024
Hospital Universitario Fundación Alcorcón
2023
Asociación Española Contra el Cáncer
2020-2022
Institució Catalana de Recerca i Estudis Avançats
2013-2021
Universitat Autònoma de Barcelona
2021
Sage Therapeutics (United States)
2021
University of Pennsylvania
2021
Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder that associates with prominent memory and behavioural deficits. Patients' antibodies react the N-terminal domain of GluN1 (previously known as NR1) subunit NMDAR causing in cultured neurons selective reversible internalization cell-surface receptors. These effects frequent response to immunotherapy have suggested an antibody-mediated pathogenesis, but date there no animal model showing patients'...
BackgroundIn non-small-cell lung cancers with programmed death-ligand 1 (PD-L1) expression on ≥50% of tumor cells, first-line treatment the PD-1 inhibitor pembrolizumab improves survival compared platinum-doublet chemotherapy. Whether higher PD-L1 levels within range 50%–100% predict for even greater benefit to is currently unknown.Patients and methodsIn this multicenter retrospective analysis, we analyzed impact overall response rate (ORR), median progression-free (mPFS), (mOS) in patients...
<h3>Objective:</h3> To report 14 patients with immune-mediated relapsing symptoms post–herpes simplex encephalitis (HSE) and to compare the clinical immunologic features of teenage adult group those young children. <h3>Methods:</h3> Prospective observational study diagnosed between June 2013 February 2015. Immunologic techniques have been reported previously. <h3>Results:</h3> Among (8 patients, median age 40 years, range 13–69; 5 male), 3 had an acute symptom presentation suggesting a viral...
Relapsing symptoms post herpes simplex virus-1 (HSV) encephalitis (HSVE) usually occur a few weeks after viral therapy and represent either 1) true relapse of HSVE (CSF PCR positive for HSV, new necrotic lesions on brain MRI, response to acyclovir therapy) or 2) disorder postulated be immune-mediated negative no lesions, acyclovir).1,2 It has been suggested that this may related NMDA receptor (NMDAR) antibodies,3 we recently reported child in whom relapsing were the presentation anti-NMDAR...
To demonstrate that ephrin-B2 (the ligand of EphB2 receptor) antagonizes the pathogenic effects patients' N-methyl-D-aspartate receptor (NMDAR) antibodies on memory and synaptic plasticity.One hundred twenty-two C57BL/6J mice infused with cerebrospinal fluid (CSF) from patients anti-NMDAR encephalitis or controls, without ephrin-B2, were investigated. CSF was through ventricular catheters connected to subcutaneous osmotic pumps over 14 days. Memory, behavioral tasks, locomotor activity,...
Immune checkpoint inhibitors (ICIs) are standard therapies for patients with advanced non-small-cell lung cancer (NSCLC) and a programmed death-ligand 1 (PD-L1) tumor proportion score (TPS) ≥50%. Tumor mutation burden (TMB) also predicts response to ICIs but is often not available in real time decision making the first-line setting. Smoking exposure can be proxy TMB NSCLC. The impact of smoking status on efficacy PD-1 blockade NSCLC PD-L1 TPS ≥50% has been well defined.To investigate...
In solid tumors, cancer stem cells (CSCs) can arise independently of epithelial-mesenchymal transition (EMT). spite recent efforts, the metabolic reprogramming associated with CSC phenotypes uncoupled from EMT is poorly understood. Here, by using metabolomic and fluxomic approaches, we identify major profiles that differentiate metastatic prostate epithelial CSCs (e-CSCs) non-CSCs expressing a stable EMT. We have found e-CSC program in our cellular model characterized high plasticity energy...
Germline mutations in STK11, which encodes the tumor suppressor liver kinase B1 (LKB1), promote Peutz-Jeghers syndrome (PJS), a cancer predisposition characterized by development of gastrointestinal (GI) polyps. Here, we report that heterozygous deletion Stk11 T cells (LThet mice) is sufficient to GI polyposis. Polyps from LThet mice, Stk11+/- and human PJS patients display hallmarks chronic inflammation, marked inflammatory immune-cell infiltration, signal transducer activator transcription...
Abstract Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is an immune-mediated disease characterized by a complex neuropsychiatric syndrome in association with antibody-mediated decrease of NMDAR. About 85% patients respond to immunotherapy (and removal associated tumour if it applies), but often takes several months or more than 1 year for recover. There are no complementary treatments, beyond immunotherapy, accelerate this recovery. Previous studies showed that SGE-301, synthetic...
The encephalitis associated with antibodies against contactin-associated proteinlike 2 (CASPR2) is presumably antibody-mediated, but the antibody effects and whether they cause behavioral alterations are not well known. Here, we used a mouse model of patients' immunoglobulin G (IgG) transfer super-resolution microscopy to demonstrate pathogenicity.IgG from patients anti-CASPR2 or healthy controls was infused into cerebroventricular system mice. levels colocalization CASPR2 transient axonal...
Ghrelin, the endogenous ligand of GH secretagogue receptor (GHS-R), is a newly identified, ubiquitously expressed molecule that has been involved in wide array endocrine and nonendocrine functions, including cell proliferation. In this context, our group recently reported expression ghrelin its functional receptor, GHS-R type 1a, human ovary testis as well several testicular tumors. Ovarian malignancies, however, remain unexplored. Notably, vast majority ovarian tumors derive from surface...
Metabolic reprogramming, a crucial cancer hallmark, shifts metabolic pathways such as glycolysis, tricarboxylic acid cycle or lipogenesis, to enable the growth characteristics of cells. Here, we provide evidence that transketolase-like 1 (TKTL1) orchestrates aerobic fatty and nucleic synthesis, glutamine metabolism, protection against oxidative stress cell proliferation. Furthermore, silencing TKTL1 reduced levels sphingolipids lactosylceramide (a sphingolipid regulating survival,...
The neuropathological hallmark of Parkinson's disease is the loss dopaminergic neurons in pars compacta substantia nigra (SNc). degenerative process starts unilaterally and spreads to system both hemispheres. However, complete characterization lesion subsequent changes basal ganglia nuclei activity has not yet been achieved vivo. aim this study was characterize time course nigral vivo, using longitudinal T2 relaxometry diffusion tensor imaging, activity, manganese-enhanced magnetic resonance...
Objective The aim was to demonstrate that antibodies from patients with anti‐ N ‐methyl‐ d ‐aspartate receptor (NMDAR) encephalitis alter the levels of dopamine 1 (D1R) and 2 (D2R) cause psychotic‐like features in mice. Methods Cultured rat hippocampal neurons were treated cerebrospinal fluid (CSF) anti‐NMDAR or controls, effects on clusters D1R D2R quantified. In vivo studies included 71 C57BL/6J mice chronically infused CSF controls through ventricular catheters connected subcutaneous...
Colorectal cancer (CRC) is associated with metabolic and redox perturbation. The mitochondrial transporter uncoupling protein 2 (UCP2) controls cell proliferation in vitro through the modulation of cellular metabolism, but underlying mechanism tumors vivo remains unexplored. Using murine intestinal models CRC patient samples, we find higher UCP2 levels compared to their non-tumoral counterparts. We reveal tumor-suppressive role as its deletion enhances colon small tumorigenesis...
Epithelial-mesenchymal-transition promotes intra-tumoral heterogeneity, by enhancing tumor cell invasiveness and promoting drug resistance. We integrated transcriptomic data for two clonal subpopulations from a prostate cancer line (PC-3) into genome-scale metabolic network model to explore their differences potential vulnerabilities. In this dual model, PC-3/S cells express markers display high low metastatic potential, while PC-3/M present the opposite phenotype higher proliferative rate....