A5081745679- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Frailty in Older Adults
- Lung Cancer Research Studies
- Radiopharmaceutical Chemistry and Applications
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Occupational and environmental lung diseases
- Nutrition and Health in Aging
- Cancer survivorship and care
- Inflammatory Biomarkers in Disease Prognosis
- Pleural and Pulmonary Diseases
- Cancer Treatment and Pharmacology
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Medical Imaging Techniques and Applications
- Circular RNAs in diseases
- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- COVID-19 and healthcare impacts
- Multiple Myeloma Research and Treatments
- Ovarian cancer diagnosis and treatment
Hospital General Universitario de Ciudad Real
2024
Hospital Universitario La Paz
2013-2023
University of Nevada, Las Vegas
2015-2022
New York Institute of Technology
2022
Centro de Investigación Biomédica en Red de Cáncer
2020-2021
Universidad Autónoma de Madrid
2020-2021
Hospital La Paz Institute for Health Research
2012-2021
Centro Universitário São Camilo
2021
Fundação Faculdade de Medicina
2020
Light Prescriptions Innovators (Spain)
2020
Patients with lung cancer may suffer from sexual dysfunction (SD) related to oncological treatment. This is an under-recognized condition among clinicians. The aim of this study was describe the prevalence SD in a multicenter cohort patients. multicenter, cross-sectional, observational conducted between July 2023 and February 2024. Sexual function assessed by patient-reported outcome (PRO) system using sex-specific questionnaire. Descriptive analysis evaluation differences categorical...
Infections with Encephalitozoon (phylum Microspora) protozoa in immunodeficient patients have emerged worldwide. The prevalence of infections due to species nonclinical populations remains unclear. We conducted a cross-sectional survey two rural highland villages Mexico by using monoclonal antibody 3B6 immunofluorescence assess the spores human stools. found that 20 (7.84%) 255 subjects were positive and 15 (21.4%) 70 households had at least one member who was positive. These results suggest...
Abstract Background Standard oncology tools are inadequate to distinguish which older patients at higher risk of developing chemotherapy-related complications. Materials and Methods Patients over 70 years age starting new chemotherapy regimens were prospectively included in a multicenter study. A prechemotherapy assessment that sociodemographics, tumor/treatment variables, geriatric variables was performed. Association between these factors the development grade 3–5 toxicity examined by...
Several platforms for noninvasive EGFR testing are currently used in the clinical setting with sensitivities ranging from 30% to 100%. Prospective studies evaluating agreement and sources discordant results remain lacking. Herein, seven methodologies including two next-generation sequencing (NGS)-based methods, three high-sensitivity PCR-based platforms, FDA-approved methods were compared using 72 plasma samples, EGFR-mutant non-small-cell lung cancer (NSCLC) patients progressing on a...
Contaminated surfaces are one of the ways that coronavirus disease 2019 (COVID-19) may be transmitted. SARS-CoV-2 can detected on environmental surfaces; however, few sampling studies have been conducted in nonclinical settings. The objective this study was to detect RNA public areas Las Vegas, Nevada. In total, 300 surface samples were collected from high-touch high-congregate locations and a health facility (PHF) visited by COVID-19 patients. Environmental analyzed with quantitative...
In recent studies, periodontal health has been linked to being overweight and/or obese. Among common oral bacteria, Selenomonas noxia implicated in converting disease, and species have also found gastric ulcers. The objective of this study was develop validate a quantitative polymerase chain reaction (qPCR) assay for the specific rapid detection S. noxia.Two oligonucleotide primer pairs one probe were designed tested determine optimal amplification signal with three strains noxia. PCR...
Purpose: To determine the incidence of unplanned hospitalization (UH) and to identify risk factors for UH in elderly patients with cancer who start chemotherapy. Methods: In all, 493 over 70 years starting new chemotherapy regimens were prospectively included. A pre-chemotherapy geriatric assessment was performed, tumor treatment variables collected. The association between these examined by using multivariable logistic regression. Score points assigned each factor. Results: During first 6...
Purpose: To identify risk factors for toxicity, unplanned hospitalization (UH) and early death (ED) in older patients with colorectal carcinoma (CRC) initiating chemotherapy. Methods: 215 over 70 years were prospectively included. Geriatric assessment was performed before treatment, tumor treatment variables collected. The association between these grade 3–5 UH ED (<6 months) examined by using multivariable logistic regression. Score points assigned to each factor. Results: During the...
Among the side effects of anticancer treatment, chemotherapy-induced nausea and vomiting (CINV) is one most feared given its high prevalence, affecting up to 40% patients. It can impair patient's quality life provoke low adherence cancer treatment or chemotherapy dose reductions that comprise efficacy. Suffering CINV depends on factors related intrinsic emetogenicity antineoplastic drugs patient characteristics. appear at different times regarding administration antitumor variability risk...
Bevacizumab plus taxane chemotherapy improves progression-free survival (PFS) versus monotherapy in the first-line treatment of HER2-negative metastatic breast cancer (MBC) and appears promising second-line setting. This retrospective analysis evaluated efficacy safety this combination a real-world setting.Eligible patients received bevacizumab (10 mg/kg days 1 15, every 28 days) paclitaxel (80 mg/m(2) 1, 8, as therapy for MBC, or subsequent lines, including continuation therapy, at La Paz...
Background: Estimation of life expectancy in older patients is relevant to select the best treatment strategy. We aimed develop and validate a score predict early mortality with cancer. Patients Methods: A total 749 over 70 years starting new chemotherapy regimens were prospectively included. prechemotherapy assessment that included sociodemographic variables, tumor/treatment geriatric variables was performed. Association between these factors death examined using multivariable logistic...
Predicting response to treatment in high-grade serous ovarian carcinoma (HGSOC) still remains a clinical challenge. The standard-of-care for first-line chemotherapy, based on combination of carboplatin and paclitaxel, achieves high rate. However, the development drug resistance is one major limitations efficacy. Therefore, identification biomarkers able predict chemotherapy patients with HGSOC critical step prognosis disease. Several studies suggest that angiogenesis an important process...
Despite often leading to platinum resistance, platinum-based chemotherapy continues be the standard treatment for many epithelial tumors. In this study we analyzed and validated cytogenetic alterations that arise after in four lung ovarian paired cisplatin-sensitive/resistant cell lines by 1-million microarray-based comparative genomic hybridization (array-CGH) qRT-PCR methodologies. RNA-sequencing, functional transfection assays, gene-pathway activity analysis were used identify genes with...
Identifying the druggable target is crucial for patients with nonsquamous advanced non-small cell lung cancer (NSCLC). This article adds to spectrum of ROS1 fusion cases described in NSCLC. We describe a novel SLC12A2-ROS1 rearrangement that has not been previously reported other cancers: clinical and radiological sensitivity crizotinib. Fluorescence situ hybridization detected it was confirmed through hybrid capture-based next-generation sequencing (NGS); however, could be by amplicon-based...