A5005025032- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Advanced Breast Cancer Therapies
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Economic and Financial Impacts of Cancer
- Microbial metabolism and enzyme function
- Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Cell Adhesion Molecules Research
- Renal cell carcinoma treatment
- Angiogenesis and VEGF in Cancer
- Endometrial and Cervical Cancer Treatments
Instituto de Investigación Sanitaria de Santiago
2016-2025
Servicio Gallego de Salud
2016-2025
Universidade de Santiago de Compostela
2013-2025
Centro de Investigación Biomédica en Red de Cáncer
2017-2025
Hospital Clínico Universitario de Valladolid
2019-2025
Complejo Hospitalario Universitario de Santiago
2015-2024
Complexo Hospitalario Universitario A Coruña
2014-2024
Roche (Spain)
2017-2024
Instituto de Salud Carlos III
2017-2024
Centro de Investigación en Red en Enfermedades Cardiovasculares
2024
BackgroundRAS assessment is mandatory for therapy decision in metastatic colorectal cancer (mCRC) patients. This determination based on tumor tissue, however, genotyping of circulating (ct)DNA offers clear advantages as a minimally invasive method that represents heterogeneity. Our study aims to evaluate the use ctDNA an alternative determining baseline RAS status and subsequent monitoring mutations during component routine clinical practice.Patients methodsRAS mutational plasma was...
Lack of effective tumor-specific delivery systems remains an unmet clinical challenge for successful translation innovative therapies, such as, therapeutic oligonucleotides. In the past decade, exosomes have been suggested to be ideal drug with application in a broad range pathologies including cancer, due their organotropic properties. Tumor-derived exosomes, having tumor-homing properties, can efficiently reach cancer cells and therefore behave as carriers improved primary tumor...
Objectives. To estimate the effect of SLE disease activity, observed over a 12-month period, on risk irreversible organ damage and mortality, adjusted for potential confounding factors. Methods. Patients were enrolled into prospective cohort study followed up from 1991. This retrospectively analyses data captured in study. The population consisted 350 patients with (meeting four or more revised ACR criteria) at University College Hospital, London lupus clinic. Disease activity was assessed...
The lysyl oxidase-like protein LOXL2 has been suggested to contribute tumor progression and metastasis, but in vivo evidence lacking. Here we provide functional that is a key driver of breast cancer metastasis two conditional transgenic mouse models PyMT-induced cancer. ablation mammary cells dramatically decreased lung whereas overexpression promoted metastatic growth. depletion or does not affect extracellular matrix stiffness organization primary tumors, implying function for independent...
Abstract Endometrial cancer (EC) is the most frequent of invasive tumors female genital tract. Although usually detected in its initial stages, a 20% patients present with advanced disease. To date, no characterized molecular marker has been validated for diagnosis EC. In addition, new methods prognosis and classification EC are needed to combat this deadly We thus aimed identify markers evaluate their validity on endometrial aspirates. Gene expression screening 52 carcinoma samples series...
In the present study we investigated prognostic value of Circulating Tumour Cells (CTC) and their utility for therapy monitoring in non-small cell lung cancer (NSCLC). A total 43 patients newly diagnosed with NSCLC were prospectively enrolled. Blood samples obtained before 1st, 2nd 5th cycles chemotherapy analyzed using CellSearch technology. Both CTC CTC-related objects (not morphological standard or broken epithelial cells) counted. At baseline 18 (41.9%) positive intact count 10 (23.2%)...
About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk unfavorable prognosis. In the framework European Network for Individualized Treatment in EC (ENITEC), we investigated presence and phenotypic features Circulating Tumor Cells (CTC) patients. CTC isolation was carried out peripheral blood samples from 34 patients, ranging Grade 3 Stage IB to IV carcinomas recurrences, 27 healthy controls using two methodologies. Samples were subjected EpCAM-based...
The HER2-enriched (HER2-E) subtype within HER2-positive (HER2+) breast cancer is highly addicted to the HER2 pathway. However, ∼20-60% of HER2+/HER2-E tumors do not achieve a complete response following anti-HER2 therapies. Here we evaluate gene expression data before, during and after neoadjuvant treatment with lapatinib trastuzumab in PAMELA trial cell lines. Our results reveal that dual blockade HER2-E disease induces low-proliferative Luminal A phenotype both patient's vitro models....
Liquid biopsy offers unique opportunities for low invasive diagnosis, real-time patient monitoring and treatment selection. The phenotypic molecular profile of circulating tumor cells (CTCs) can provide key information about the biology cells, contributing to personalized therapy. CTC isolation is still challenging, mainly due their heterogeneity rarity. To overcome this limitation, a microfluidic chip label-free CTCs from peripheral blood was developed. This device, CROSS chip, captures...
The tumor microenvironment (TME) is gaining increasing attention in oncology, as it recognized to be functionally important during development and progression. Tumors are heterogeneous tissues that, addition cells, contain tumor-associated cell types such immune fibroblasts, endothelial cells. These other together with the specific extracellular matrix (ECM), create a permissive environment for growth. While influence of tumor-infiltrating cells mechanical properties ECM invasion progression...
Breast cancer (BC) treatment with anthracyclines and/or anti-human epidermal growth factor receptor-2 (HER2) antibodies is associated an increased risk of cardiovascular disease complications, including therapy-related cardiac dysfunction (CTRCD). While Cardio-Oncology Rehabilitation (CORe) programs exercise have emerged to minimize these risks, its role in preventing CTRCD unclear.
Abstract Purpose: The aim of PREDICT was to confirm clinical validity and the potential for utility serial circulating tumor cell (CTC) enumeration in metastatic breast cancer (MBC) patients focusing on its prognostic value different subtypes settings. Experimental design: In total, 4436 individual patient-level data with CTC results from both baseline one follow-up (CellSearch®; Menarini Silicon Biosystems) were analyzed evaluate association between detection overall survival (OS) full...
To determine the tolerability of capecitabine in elderly patients with advanced colorectal cancer (CRC).Fifty-one CRC who were >/= 70 years and considered ineligible for combination chemotherapy received oral 1,250 mg/m(2) twice daily on days 1 to 14 every 3 weeks. Patients a creatinine clearance 30 50 mL/min dose 950 daily.A total 248 cycles administered (median, five cycles; range, one eight cycles). The overall response rate was 24% (95% CI, 15% 41%), including two complete responses (CR;...
Metastatic colorectal cancer (mCRC) relies on the detachment of aggressive malignant cells from primary tumor into bloodstream and, concordantly, presence these Circulating Tumor Cells (CTC) is associated with a poor prognosis. In this work, molecular characterization CTC mCRC patients was approached, aim understanding their biology and improving clinical utility in management patients. For this, EpCAM-based immunoisolation combined whole transcriptome amplification hybridization onto cDNA...
Remodeling targeted tissues for reception of tumor cells metastasizing from primary lesions is a consequence communication between the and environment that governs metastasis. This study describes novel approach aims to disrupt process metastasis by interfering with this intense dialogue. Proteomics adhesion assays identified exosomes purified ascitic fluid ovarian cancer patients (n = 9) as intermediaries cell attachment. A capture device was fabricated embedding onto 3D scaffold...