A5062301538- Endometrial and Cervical Cancer Treatments
- RNA Research and Splicing
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Essential Oils and Antimicrobial Activity
- Helicobacter pylori-related gastroenterology studies
- Monoclonal and Polyclonal Antibodies Research
- Gastrointestinal motility and disorders
- Contact Dermatitis and Allergies
- Cell Adhesion Molecules Research
- Ovarian cancer diagnosis and treatment
- Urticaria and Related Conditions
- Gynecological conditions and treatments
- Sesquiterpenes and Asteraceae Studies
- Oral Health Pathology and Treatment
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Ocular Surface and Contact Lens
- Veterinary medicine and infectious diseases
- Phytochemical Studies and Bioactivities
- Aquaculture Nutrition and Growth
- Advancements in Transdermal Drug Delivery
- Food Allergy and Anaphylaxis Research
- Crystallization and Solubility Studies
- Cancer-related molecular mechanisms research
Reig Jofre (Spain)
2013-2023
Oryzon Genomics (Spain)
2008-2012
Universitat de Barcelona
2008
Merck & Co., Inc., Rahway, NJ, USA (United States)
1994
Abstract Endometrial cancer (EC) is the most frequent of invasive tumors female genital tract. Although usually detected in its initial stages, a 20% patients present with advanced disease. To date, no characterized molecular marker has been validated for diagnosis EC. In addition, new methods prognosis and classification EC are needed to combat this deadly We thus aimed identify markers evaluate their validity on endometrial aspirates. Gene expression screening 52 carcinoma samples series...
The Senegalese sole, Solea senegalensis, is a highly prized flatfish of growing commercial interest for aquaculture in Southern Europe. However, despite the industrial production sole being hampered primarily by lack information on physiological mechanisms involved reproduction, growth and immunity, very limited genomic available this species. Sequencing S. senegalensis multi-tissue normalized cDNA library, from adult tissues (brain, stomach, intestine, liver, ovary, testis), larval stages...
Abstract Enhanced expression of epidermal growth factor receptor (EGFR) occurs on a variety malignant tissues thus making anti‐EGFR antibodies possible agents for the diagnosis and therapy human tumors. Standard hybridoma technology has been used successfully to isolate from immunized mice rats. This report demonstrates that phage‐antibody libraries are an alternative, more versatile, method isolating mice. Anti‐EGFR were isolated constructed not only spleen mouse but also draining lymph...
Collagen Triple Helix Repeat Containing-1 (CTHRC1) and Nuclear factor (erythroid-derived 2)-like 3 (NFE2L3) may be useful biomarker candidates for the diagnosis of colorectal cancer (CRC) since they have shown an increase messenger RNA transcripts (mRNA) expression level in adenomas tumours when compared to normal tissues. To evaluate CTHRC1 NFE2L3 as biomarkers, it was generated characterised several novel specific polyclonal antibodies (PAb), monoclonal (MAbs) soluble Fab fragments (sFabs)...
Rapid and reliable diagnosis of endometrial cancer (EC) in uterine aspirates is highly desirable. Current sensitivity failure rate histological limit the success this method subsequent hysteroscopy often necessary. Using quantitative reverse transcriptase-polymerase chain reaction on RNA from samples, we measured expression level 20 previously identified genes involved EC pathology, created five algorithms based combinations evaluated their ability to diagnose EC. The were tested a...
Helicobacter pylori is the main pathogen responsible for gastric ulcers and a predisposing factor of stomach cancer. Although current treatment usually successful, it requires high doses frequent administration. An innovative mucoadhesive system (Mucolast®) loaded with amoxicillin clarithromycin proposed to improve efficacy against H. pylori. The drug product was optimized based on its viscoelastic properties obtain long-term stability vehicle. release mechanisms were different both...
Antimicrobial drugs applied topically offer several advantages. However, the widespread use of antibiotics has led to increasing antimicrobial resistance. One interesting approach in drug discovery process is repurposing. Disulfiram, which was originally approved as an anti-alcoholism drug, offers attractive alternative treat topical multidrug resistance bacteria skin human infections. This study aimed evaluate biopharmaceutical characteristics and effects arising from its application...
5066 Background: We report the development of a gene expression (GE) based test to detect endometrial cancer (EC). Validation in multicenter validation study conducted over 10 different hospitals Spain is ongoing. Methods: Discovery: Seventy tissue samples (60 EC + normal) were collected from women with abnormal uterine bleeding (AUB) that submitted biopsy or tumor resection. Microarray GE analysis was performed at Oryzon yield candidate set. Initial validation: An independent cohort normal...