A5048414219- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Health and Medical Education
- Congenital heart defects research
- Genetic Syndromes and Imprinting
- Higher Education Teaching and Evaluation
- Thyroid Disorders and Treatments
- Inflammatory Bowel Disease
- Developmental Biology and Gene Regulation
- Inflammasome and immune disorders
- Birth, Development, and Health
- Systemic Lupus Erythematosus Research
- Cholesterol and Lipid Metabolism
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Biomarkers in Disease Mechanisms
- IL-33, ST2, and ILC Pathways
- Gastrointestinal motility and disorders
- Maternal and fetal healthcare
- Eicosanoids and Hypertension Pharmacology
- Natural product bioactivities and synthesis
- Pregnancy and preeclampsia studies
- Atherosclerosis and Cardiovascular Diseases
- Botanical Research and Chemistry
- Circadian rhythm and melatonin
Universidad de Sevilla
2013-2024
Centro de Epilepsia y Neurocirugía Funcional
2020-2022
Chartered Institute of Management Accountants
2022
Faculty (United Kingdom)
2020
College of Podiatry
2020
Introduction Crohn’s disease (CD) involves activation of mast cells (MC) and NF-кB in parallel with the PPAR-α/NLRP3 inflammasome/IL-1β pathway inflamed colon. Whether polyphenols from maqui ( Aristotelia chilensis ) represent a natural alternative treatment for CD is unclear. Therefore, we used an animal model 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced CD-like colitis to investigate protective effects extract through monitoring NLRP3 inflammasome MC colon tissue. Methods Maqui was...
Metabolic-associated fatty liver disease (MAFLD) is the most important cause of worldwide. It characterized by accumulation fat in and closely associated with abdominal obesity. In addition, oxidative stress inflammation are significant features involved MAFLD. Recently, our group demonstrated that lupin protein hydrolysates (LPHs) had lipid lowering, antioxidant, anti-inflammatory effects. Sixty male mice fed a Western diet were intragastrically treated LPHs (or vehicle) for 12 weeks. Liver...
Nutraceuticals include a wide variety of bioactive compounds, such as polyphenols, which have been highlighted for their remarkable health benefits. Specially, maqui berries shown great antioxidant activity and anti-inflammatory effects on some inflammatory diseases. The objectives the present study were to explore therapeutic acute-phase inflammation in Crohn’s disease. Balb/c mice exposed 2,4,6-trinitrobenzene sulfonic acid (TNBS) via intracolonic administration. Polyphenolic extract (Ach)...
The best conservation method for native Chilean berries has been investigated in combination with an implemented large-scale extract of maqui berry, rich total polyphenols and anthocyanin to be tested intestinal epithelial immune cells. methanolic was obtained from lyophilized analyzed using Folin–Ciocalteu quantify the polyphenol content, as well 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC) measure capacity....
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease without an effective and safe treatment.
Primary cilia (PC) are conserved structures in the adult thyroid gland of different mammals. It was recently described that humans, PC usually present as a single copy per follicular cell emerging from apex into lumen.To understand role developed by hormonogenesis better, their changes human functional diseases (diffuse toxic hyperplasia/Graves' disease [GD] and nodular hyperplasia [NH]/nodular goiter), comparison to normal tissue, were investigated using immunofluorescence, morphometry,...
Abstract Since their discovery in different human tissues by Zimmermann 1898, primary cilia have been found the vast majority of cell types vertebrates. Primary are considered to be cellular antennae that occupy an ideal location for interpretation information both from environment and other cells. To date, mammalian thyroid gland, thyrocytes humans dogs (fetuses adults) rat embryos. The present study investigated whether existence this organelle follicular cells is a general event postnatal...
Helicobacter pylori is the main pathogen responsible for gastric ulcers and a predisposing factor of stomach cancer. Although current treatment usually successful, it requires high doses frequent administration. An innovative mucoadhesive system (Mucolast®) loaded with amoxicillin clarithromycin proposed to improve efficacy against H. pylori. The drug product was optimized based on its viscoelastic properties obtain long-term stability vehicle. release mechanisms were different both...
Systemic lupus erythematosus (SLE) is a chronic immune-inflammatory disease characterized by multiorgan affectation and lowered self-tolerance. Additionally, epigenetic changes have been described as playing pivotal role in SLE. This work aims to assess the effects of oleacein (OLA), one main extra virgin olive oil secoiridoids, when used supplement diet murine pristane-induced SLE model. In study, 12-week-old female BALB/c mice were injected with pristane fed an OLA-enriched (0.01 % (w/w))...
Olacein (OLA), one of the main secoiridoids derived from extra virgin olive oil (EVOO), has been shown to modulate oxidative and inflammatory responses in various pathological conditions; however, its potential benefit joint disorders such as rheumatoid arthritis (RA) is unknown. Therefore, this study was designed evaluate preventive role effects an OLA-supplemented diet murine model collagen-induced (CIA), delving into possible mechanisms signaling pathways involved. Animals were fed...
Ultimobranchial (UB) remnants are a constant presence in the thyroid throughout rat postnatal life; however, difficulty identifying most immature forms from surrounding tissue prompted us to search for specific marker. With that objective, we applied panel of antibodies reported be their human counterpart, solid cell nests (SCNs), using double immunohistochemistry and immunofluorescence. Our results demonstrated cytokeratin 34βE12 p63 highly sensitive markers immunohistologic screening...
Abstract The ultimobranchial follicles (UBFs) are considered embryonic remnants from the body (UBB). They follicular structures that vary in size and appearance depending on age of rat. main objective this article was to study progressive changes shape, size, frequency UBFs postnatal rat, birth old‐age. To accomplish objective, a systematic morphometric incidental UBF has been carried out 110 Wistar rats different ages both sexes, divided into three groups: 1) young (5–90‐day‐old); 2) adult...
Pendred syndrome (PDS) is an autosomal recessive disorder caused by mutations in the gene that encodes pendrin. thyroid tissue supposedly altered absence of functional pendrin, but it still unknown whether other iodide exchangers could compensate for loss protein. Moreover, we have recently described primary cilium, a conserved structure present at apical surface normal follicular cells, suffers different alterations diseases. We aimed (1) to better understand histopathological changes...
Abstract Background In mammals, the thyroid gland possesses two types of endocrine cells, follicular cells and C which have different functions but share a similar endodermal origin (although from regions primitive pharynx). Specifically, derive ventral pharyngeal floor, while fourth pair pouches through ultimobranchial bodies (UBBs). Disruptions to human midline morphogenesis are relatively frequent known as dysgenesis, is leading cause congenital hypothyroidism. contrast, branchial...
Here, ultrastructural analysis of primary cilia in human thyroid follicles revealed a direct relationship between frequency and length the functional state individual follicle normal compared to hyperfunctioning tissues.