A5075228356- Genomics, phytochemicals, and oxidative stress
- Catalytic C–H Functionalization Methods
- Sphingolipid Metabolism and Signaling
- Plant-derived Lignans Synthesis and Bioactivity
- Systemic Lupus Erythematosus Research
- Fluorine in Organic Chemistry
- Eicosanoids and Hypertension Pharmacology
- IL-33, ST2, and ILC Pathways
- Cyclopropane Reaction Mechanisms
- Reproductive System and Pregnancy
- Ginger and Zingiberaceae research
- Free Radicals and Antioxidants
- Cholesterol and Lipid Metabolism
- Bioactive Compounds and Antitumor Agents
Universidad de Sevilla
2018-2024
Hospital Universitario Virgen del Rocío
2023-2024
Instituto de Biomedicina de Sevilla
2022-2024
Junta de Andalucía
2022-2023
Abstract An efficient sulfinamide/olefin based chiral ligand, MetSulfolefin , has been developed for the enantioselective rhodium‐catalysed addition of aryl‐boronic acids to trifluoromethyl ketones. This shelf‐stable ligand is insensitive air, oxygen and moisture, it obtained in only two high yielding steps from cheap commercially available ( R )‐ tert ‐butanesulfinamide. The new tolerates use hindered boronic leads formation a series trifluoromethyl‐substituted tertiary carbinols yields...
The present study was designed to evaluate the immunomodulatory effects of secoiridoid from extra virgin olive oil, oleacein (OLA), deepening into possible signaling pathways involved in LPS-activated murine peritoneal macrophages. Moreover, we have explored OLA-induced epigenetic changes histone markers and related cytokine production LPS-stimulated splenocytes. Murine cells were treated with OLA presence or absence LPS (5 μg/mL) for 18 24 h. modulated oxidative stress inflammatory response...
The aim of this study was to explore the immunomodulatory effects natural enantiomer (R)-Sulforaphane (SFN) and possible signaling pathways involved in an ex vivo model LPS-stimulated murine peritoneal macrophages. Furthermore, we studied epigenetic changes induced by (R)-SFN as well post-translational modifications histone H3 (H3K9me3 H3K18ac) relation production cytokines splenocytes after LPS stimulation. able modulate inflammatory response oxidative stress stimulation macrophages through...
Hirsutin, synthesized in a novel way by the “DAG methodology”, showed antioxidant and anti-inflammatory effects immune murine cells.
The present study aimed to investigate the effects of (
Systemic lupus erythematosus (SLE) is a chronic immune-inflammatory disease characterized by multiorgan affectation and lowered self-tolerance. Additionally, epigenetic changes have been described as playing pivotal role in SLE. This work aims to assess the effects of oleacein (OLA), one main extra virgin olive oil secoiridoids, when used supplement diet murine pristane-induced SLE model. In study, 12-week-old female BALB/c mice were injected with pristane fed an OLA-enriched (0.01 % (w/w))...