A5067041688- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Genomics, phytochemicals, and oxidative stress
- Chemical Synthesis and Reactions
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Crystallography and molecular interactions
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Cancer therapeutics and mechanisms
- Carbohydrate Chemistry and Synthesis
- Protein Degradation and Inhibitors
- Sulfur-Based Synthesis Techniques
- Bioactive Compounds and Antitumor Agents
- Fluorine in Organic Chemistry
- Synthetic Organic Chemistry Methods
- Organophosphorus compounds synthesis
- Social Sciences and Policies
- Advanced Optical Imaging Technologies
- Image and Video Quality Assessment
- Catalytic C–H Functionalization Methods
- Education Methods and Integration
Universidad de Sevilla
2015-2025
IVI Sevilla Clinic
2019
Universidad Politécnica de Madrid
2017
Centro de Investigaciones Científicas Isla de la Cartuja
2013
A new type of chiral sulfinamide phosphinate catalysts with up to three stereogenic centers, readily accessible from commercially available starting materials, is reported. The naphthyl derivative SulPhos proved be highly efficient in the organocatalytic asymmetric imine reduction, leading a wide range arylmethylamines high yields 99% ee under 10% catalyst loading. synthetic utility this method was demonstrated by expeditious enantioselective synthesis calcimimetic NPS-R568.
A series of benzoxazole-based amides and sulfonamides were synthesized evaluated for their human peroxisome proliferator-activated receptor (PPAR)α PPARγ activity. All tested compounds showed a dual antagonist profile on both PPAR subtypes; based transactivation results, seven selected to test in vitro antiproliferative activity panel eight cancer cell lines with different expression rates PPARα PPARγ. 3f was identified as the most cytotoxic compound, higher potency colorectal HT-29 HCT116....
NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in cancers. In present study, we report on synthesis carbohydrate-based antagonists and their evaluation as anticancer agents against a wide range cancer cells. All prepared compounds, derived from either d-galactose or l-arabinose, high affinity antagonistic activity with broad-spectrum an important selectivity, comparable to Cisplatin. This strategy has allowed us identify galactosyl...
Abstract An efficient sulfinamide/olefin based chiral ligand, MetSulfolefin , has been developed for the enantioselective rhodium‐catalysed addition of aryl‐boronic acids to trifluoromethyl ketones. This shelf‐stable ligand is insensitive air, oxygen and moisture, it obtained in only two high yielding steps from cheap commercially available ( R )‐ tert ‐butanesulfinamide. The new tolerates use hindered boronic leads formation a series trifluoromethyl‐substituted tertiary carbinols yields...
Abstract An improved method for the tert ‐butanesulfinylation of diacetone glucose with ‐butanesulfinyl chloride is reported. The based on a beneficial effect catalytic DMAP, which enhances both rate reaction and enantioselectivity process to give ( R S )‐diastereomer 2 94 % de in quantitative yield. )‐DAG sulfinate ester an excellent intermediate synthesis enantiopure ‐butyl sulfoxides. Grignard agents organolithium reagents can displace smoothly moiety synthetically relevant sulfoxides,...
Monosulfinamides and C2-symmetric bis-sulfinamides are convenient neutral chiral promoters in the allylation of acyl hydrazones, nature spacer substituent at sulfinyl sulfur key elements for enantioselectivity process.
The antiproliferative effects played by benzothiazoles in different cancers have aroused the interest for these molecules as promising antitumor agents. In this work, a library of phenylacetamide derivatives containing benzothiazole nucleus was synthesized and compounds were tested their activity paraganglioma pancreatic cancer cell lines. novel induced marked viability reduction at low micromolar concentrations both cells. Derivative 4l showed greater effect higher selectivity index against...
The aim of this study was to explore the immunomodulatory effects natural enantiomer (R)-Sulforaphane (SFN) and possible signaling pathways involved in an ex vivo model LPS-stimulated murine peritoneal macrophages. Furthermore, we studied epigenetic changes induced by (R)-SFN as well post-translational modifications histone H3 (H3K9me3 H3K18ac) relation production cytokines splenocytes after LPS stimulation. able modulate inflammatory response oxidative stress stimulation macrophages through...
A detailed study on the diastereoselective oxidation of 1-thio-β-D-glucopyranosides is reported. It has been shown that sense and degree stereochemical outcome are highly dependent substituent sulfur protective group C2-OH. In case thioglycosides with a bulky aglycone, mesylation C2-OH significant effect oxidation, affording usually less favoured RS sulfoxide as single diastereoisomer. The absolute configuration final sulfinyl glycosides was ascertained by NMR analysis corroborated X-ray...
Abstract A number of P ‐stereogenic N ‐phosphinyl compounds were stereoselectively prepared in good yields by a straightforward approach, thanks to the diversified and, up until now, unexplored reactivity ( R )‐ and S )‐dicyclohexylidene‐ D ‐glucose methyl phenyl phosphinates toward metal amides. Under adequate conditions, structurally different phosphinamides with one or two ‐chiral centers obtained.
The synthetic method developed for the preparation of NH 2 /SO palladium complexes proved to be also an effective approach N -desulfinylation. Furthermore, Pd demonstrated a higher trans influence PhSO compared t BuSO.
Hirsutin, synthesized in a novel way by the “DAG methodology”, showed antioxidant and anti-inflammatory effects immune murine cells.
Different studies using Aprepitant, a NK1R antagonist currently used as clinical drug for treating chemotherapy-related nausea and vomiting, have demonstrated that pharmacological inhibition of effectively reduces the growth several tumor types such neuroblastoma (NB). In previous work, we series carbohydrate-based Aprepitant analogs, derived from either d-galactose or l-arabinose, shown high affinity antagonistic activity with broad-spectrum anticancer an important selectivity. this new...
The present study aimed to investigate the effects of (
The subjective assessment of super multiview (SMV) video considers two main perceptual factors: image quality and visual comfort at the viewpoint transition. While previous works only covered raw content with high levels comfort, this work supersedes them by targeting SMV coding artifacts. outcome analysis yields important conclusions regarding relationship between these factors, indicating that perceived is independent from view point change speed, transition quality. These facilitate...
A new family of sulfinamide/sulfoxide derivatives was synthesized as chiral bidentate ligands by stereoselective additions methylsulfinyl carbanions to N-tert-butylsulfinylimines. The ligands, with C1, pseudo-meso, and pseudo-C2 symmetries, were successfully assayed in Rh-catalyzed arylboronic acids activated ketones. sterically dissymmetric C1 ligand (RS,SC,RS)-N-[1-(phenylsulfinyl)-3-methylbut-2-yl] tert-butylsulfinamide turned out be the optimal one, allowing 1,4-additions diverse acids,...
Mixed S/P ligands<bold>3</bold>and<bold>10</bold>, good catalyst precursors for the Rh(<sc>i</sc>)-catalysed 1,4-addition of phenylboronic acid to cyclohexenone behave as enantiomers even though both derived from<sc>d</sc>-sugars.
The stereoselective synthesis of two distinct types