A5006943349- Advancements in Transdermal Drug Delivery
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Advanced Drug Delivery Systems
- 3D Printing in Biomedical Research
- Pancreatic function and diabetes
- Dermatology and Skin Diseases
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Congenital heart defects research
- Graphene and Nanomaterials Applications
- Acne and Rosacea Treatments and Effects
- Cardiovascular Disease and Adiposity
- Muscle metabolism and nutrition
- Mesenchymal stem cell research
- Phytochemicals and Medicinal Plants
- Metabolism, Diabetes, and Cancer
- Drug Solubulity and Delivery Systems
- Toxin Mechanisms and Immunotoxins
- Caveolin-1 and cellular processes
- Lipid Membrane Structure and Behavior
- Endoplasmic Reticulum Stress and Disease
- Botulinum Toxin and Related Neurological Disorders
Industrial University of Santander
2019-2025
Universidad de Sevilla
2025
Hospital Clínico de la Universidad de Chile
2021
Artistic Realization Technologies
2021
Centro Nacional de Enfermedades Tropicales
2021
Instituto Maimónides de Investigación Biomédica de Córdoba
2014-2016
University of Córdoba
2014-2016
Sofia University
2015
Instituto de Salud Carlos III
2015
Centro de Investigación Biomédica en Red
2014
Curcumin (CUR) has been shown to possess significant anti-inflammatory properties and wound healing potential. Additionally, lignin (LIG) is a renewable biomacromolecule with well-known antioxidant antimicrobial properties, which makes this good candidate be included in medical materials, such as dressings. Although many of the dressings used at present have interesting features, some are limited terms antibacterial properties. To address these limitations, work, both CUR LIG were combined...
Methicillin-resistant Staphylococcus aureus (MRSA) is a prevailing bacterial pathogen linked to superficial skin and soft tissue infections (SSTIs). Rifampicin (RIF), potent antibiotic against systemic localised staphylococcal infections, faces limitations due its low solubility. This constraint hampers therapeutic potential for MRSA-induced SSTIs. To address this, an advanced liposomal system was designed efficient dermal RIF delivery. Rifampicin-loaded liposomes (LipoRIF) were embedded...
Abstract Glycerol is an important metabolite for the control of lipid accumulation in white adipose tissue (WAT) and liver. We aimed to investigate whether exogenous administration leptin improves features non-alcoholic fatty liver disease (NAFLD) leptin-deficient ob/ob mice via regulation AQP3 AQP7 (glycerol channels mediating glycerol efflux adipocytes) AQP9 (aquaglyceroporin facilitating influx hepatocytes). Twelve-week-old male wild type were divided three groups as follows: control,...
Chitosan scaffolds based on blending polymers are a common strategy used in tissue engineering. The objective of this study was evaluation the properties ternary blend chitosan (Chi), gelatin (Ge), and polyvinyl alcohol (PVA) (Chi/Ge/PVA), which were prepared by cycles freeze-thawing freeze-drying. It then for three-dimensional BRIN-BD11 beta-cells culturing. Weight ratios Chi/Ge/PVA (1:1:1, 2:2:1, 2:3:1, 3:2:1) proposed porosity, pore size, degradation, swelling rate, compressive strength,...
In this work the preparation and characterisation of intranasal implants for delivery risperidone (RIS) is described. The aim to develop better therapies treat chronic conditions affecting brain such as schizophrenia. This type systems combines advantages drug with sustained release. resulting were prepared using biodegradable materials, including poly(caprolactone) (PCL) poly(lactic-co-glycolic acid) (PLGA). These polymers combined water-soluble compounds, poly(ethylene glycol) (PEG) 600,...
Colchicine-Soluplus® was loaded into dissolving microarray patches for a new minimally-invasive alternative strategy management of acute gout.
Carvedilol, a β-blocker prescribed for chronic heart failure, suffers from poor bioavailability and rapid first pass metabolism when administered orally. Herein, we present the development of tip microarray patches (MAPs) composed ternary cyclodextrin (CD) complexes carvedilol transdermal delivery. The complex with hydroxypropyl γ-cyclodextrin (HPγCD) poly(vinyl pyrrolidone) (PVP) reduced crystallinity carvedilol, as evidenced by DSC, XRD, NMR, SEM analysis. MAPs were fabricated using...
Schizophrenia is a psychiatric disorder that results from abnormal levels of neurotransmitters in the brain. Risperidone (RIS) common drug prescribed for treatment schizophrenia. RIS hydrophobic typically administered orally or intramuscularly. Transdermal delivery (TDD) could potentially improve RIS. This study focused on development nanocrystals (NCs), first time, which were incorporated into dissolving microneedle array patches (DMAPs) to facilitate NCs formulated via wet-media milling...
To overcome the challenges of blood-brain barrier for drug delivery to central nervous system (CNS), intranasal implants were developed improve management CNS conditions, such as schizophrenia. In present work, we and characterised a drug-containing implant consisting two parts: core layer made from risperidone (RIS) water-soluble polymers, including poly(vinylpyrrolidone) (PVP) poly(ethylene glycol) (PEG), coating poly(caprolactone) (PCL) membrane. The obtained implants, where contained 75...
Aims: Obesity is characterized by a low-grade systemic inflammatory state and adipose tissue (AT) dysfunction, which predispose individuals to the development of insulin resistance (IR) metabolic disease. However, subset obese individuals, referred as metabolically healthy (MHO) are protected from obesity-associated abnormalities. Here, we aim at identifying molecular factors pathways in adipocytes that responsible for progression insulin-sensitive insulin-resistant, unhealthy (MUHO)...
Context: Molecular mechanisms associated with physiological variations in adipose tissue (AT) are not fully recognized. The most recent reports highlight the critical relevance of microRNAs (miRNAs) found AT. Objective: To identify changes messenger RNA (mRNA) and miRNA expressions their interaction human AT before after surgery-induced weight loss. Research Design Setting: Genome-wide mRNA were assessed by microarrays abdominal subcutaneous 16 morbidly obese women 2 years laparoscopic...
Research on the use of microarray patches (MAPs) has progressed at an unprecedented rate over years, leading to development many novel drug delivery systems. As technology approaches patients, there are several key aspects that ought be addressed in order facilitate smooth translation MAPs from bench bedside. One integral factor includes choice devices and packaging for storage MAPs. In current work, a slide-and-seal box, MAP-box, was developed dissolving MAPs, using fused-deposition...
In a study addressing the high risk of chronic diseases in people with diabetes and obesity linked to metabolic syndrome, impact Golden Berry diet was investigated using diabetic animal model. Obese rats characteristics were fed containing five percent for 16 days. This focused on various parameters including organ weights, expression genes, urinary biomarkers. Post-Golden intake, there notable decrease body, liver, pancreas, visceral, subcutaneous adipose tissue weights these obese,...
Abstract Implantable drug delivery systems are crucial for achieving sustained of active compounds to specific sites or systemic circulation. In this study, a novel reservoir‐type implant combining biodegradable rate‐controlling membrane with drug‐containing core prepared using direct compression techniques is developed. The composed poly(caprolactone) (PCL), and risperidone (RIS) served as the model drug. Characterization both membranes compressed pellets includes hardness testing, optical...
Schizophrenia is one of the most severe mental disorders, affecting approximately 24 million people worldwide. Conventional treatments, such as drug-loaded implants and intramuscular injections, have several limitations, including pain during administration need for medical professionals to perform procedure. In this study, a poly(lactic-co-glycolic) acid (PLGA)-based implantable microneedle patch (IMN) was developed transdermal delivery risperidone (RIS) treatment schizophrenia. RIS IMNs...
Enfuvirtide, the inaugural biomimetic fusion inhibitor of HIV-1, has exhibited remarkable antiviral efficacy when administered in conjunction with an optimized antiretroviral regimen. Nonetheless, high incidence (98%) injection site reactions associated twice-daily subcutaneous administration severely compromises patient adherence and long-term therapeutic outcomes. This study proposes hydrogel-forming microneedles (MNs) as a minimally invasive painless modality for transdermal delivery this...
Dissolving microarray patches (DMAPs) represent an innovative approach to minimally invasive transdermal drug delivery, demonstrating efficacy in delivering both small and large therapeutic molecules. However, concerns raised end-user surveys have hindered their commercialization efforts. One prevalent issue highlighted these is the lack of clear indicators for successful patch insertion removal time. To address this challenge, a color-change-based feedback system devised, which confirms...
Quercetin, a natural compound, shows promising potential in wound healing by reducing fibrosis, limiting scar formation, and boosting fibroblast proliferation. However, its effectiveness is hindered poor solubility, resulting low bioavailability necessitating high doses for therapeutic efficacy. This study presents novel approach, fabricating quercetin-loaded microarray patches (MAPs) using widely employed solubility enhancement strategies. Fabricated MAPs exhibited favourable mechanical...
Abstract Purpose This investigation aims to develop and characterise dissolving microarray patches (MAPs) loaded with ivermectin (IVM) for rosacea therapy. Methods Tween ® 80 Soluplus were evaluated enhance the water solubility of IVM powder. Three MAPs fabricated using a two-layer casting method, pure IVM-loaded (F1), IVM-Tween (F2), IVM-Soluplus (F3) patches. Formulations drug content, in vitro ex vivo mechanical performances, skin dissolution time, dermatokinetics, biocompatibility...