A5067550012- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Biochemical Analysis and Sensing Techniques
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Bone and Dental Protein Studies
- Body Composition Measurement Techniques
- Nutrition and Health in Aging
- Lipid metabolism and disorders
- Muscle metabolism and nutrition
- Eating Disorders and Behaviors
- Body Contouring and Surgery
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ion Transport and Channel Regulation
- Retinoids in leukemia and cellular processes
- Nutritional Studies and Diet
- Exercise and Physiological Responses
Clinica Universidad de Navarra
2016-2025
Instituto de Salud Carlos III
2016-2025
Centro de Investigación Biomédica en Red
2016-2025
Navarre Institute of Health Research
2016-2025
Universidad de Navarra
2008-2024
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2011-2017
Sociedad Española de Endocrinología y Nutrición
2014-2016
Instituto de Salud Pública de Navarra
2013
Weatherford College
2009
University of Liverpool
2002
Obesity is the major risk factor for development of prediabetes and type 2 diabetes. BMI widely used as a surrogate measure obesity, but underestimates prevalence defined an excess body fat. We assessed presence impaired glucose tolerance or fasting (both considered together prediabetes) diabetes in relation to criteria diagnosis obesity using compared fat percentage (BF%). performed cross-sectional study including 4,828 (587 lean, 1,320 overweight, 2,921 obese classified according BMI)...
BACKGROUND Genomic studies have yielded important insights into the pathogenesis of obesity. Circulating microRNAs (miRNAs) are valuable biomarkers systemic diseases and potential therapeutic targets. We sought to define circulating pattern miRNAs in obesity examine changes after weight loss. METHODS assessed genomewide miRNA profile cross-sectionally 32 men surgery-induced loss 6 morbidly obese patients. The most relevant were validated 80 longitudinally 22 patients (after loss). evaluated...
To assess the predictive capacity of a recently described equation that we have termed CUN-BAE (Clínica Universidad de Navarra-Body Adiposity Estimator) based on BMI, sex, and age for estimating body fat percentage (BF%) to study its clinical usefulness.We conducted comparison developed with many other anthropometric indices regarding correlation actual BF% in large cohort 6,510 white subjects from both sexes (67% female) representing wide range ages (18-80 years) adiposity. Additionally,...
Background Extreme weight conditions (EWC) groups along a continuum may share some biological risk factors and intermediate neurocognitive phenotypes. A core cognitive trait in EWC appears to be executive dysfunction, with focus on decision making, response inhibition flexibility. Differences between individuals these areas are likely contribute the differences vulnerability EWC. The aim of study was investigate whether there is common pattern dysfunction while comparing anorexia nervosa...
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin circulating elevated obese subjects. The aim this study was to evaluate levels conditions extreme BMI its correlation with basal metabolism daily activity. involved 145 female patients, including 96 BMIs (30 anorexic (AN) 66 (OB)) 49 healthy normal weight (NW)....
Obesity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D) and metabolic syndrome (MS). MS are distinguished by an increase in circulating leptin concentrations, parallel to a drop levels adiponectin. Consequently, Adpn/Lep ratio has been suggested maker dysfunctional adipose tissue. We aimed investigate humans (n = 292) reliability biomarker tissue dysfunction. considered that ≥1.0 can be normal, ≥0.5 <1.0 suggests moderate-medium increased risk, <0.5...
The aim of the present work was to study whether leptin-adiponectin axis may have a pathophysiological role in increased systemic inflammation and oxidative stress observed patients with metabolic syndrome (MS). Leptin, adiponectin, markers were measured sample 140 Caucasian subjects (74 males/66 females), aged 28-82 years, 60 80 without MS. Total concentrations adiponectin as well its multimeric forms HMW, MMW LMW significantly lower individuals ratio adiponectin/leptin, marker...
Bone has recently been described as exhibiting properties of an endocrine organ by producing osteocalcin that increases insulin sensitivity and secretion in animal models.We aimed to evaluate circulating association with three different studies nondiabetic subjects: one cross-sectional study 149 men (using minimal model), two longitudinal independent groups (one formed 26 women, the other 9 11 women), after a mean 7.3 16.8% weight loss, 8.7% loss plus regular exercise.In study, was...
Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance obesity. We aimed to study the effects of weight loss-induced improved sensitivity on circulating omentin concentrations.Circulating omentin-1 (ELISA) concentration association metabolic variables was measured 35 obese subjects (18 men, 17 women) before after hypocaloric loss.Baseline concentrations correlated BMI (r = -0.58, p < 0.001), body -0.35, 0.045), fat mass -0.67,...
Objective:Glycerol constitutes an important metabolite for the control of lipid accumulation and glucose homeostasis. The impact obesity obesity-associated type 2 diabetes as well potential regulatory role insulin leptin on aquaglyceroporins (AQP) 3, 7, 9 were analyzed.
Abstract Context: Obesity acts as a cardiovascular risk factor by mechanisms that are not fully understood. Osteopontin (OPN) is proinflammatory mediator involved in tissue remodeling plays role atherosclerosis and diabetes. Objective: The aim of the present study was to compare circulating concentrations OPN its mRNA expression omental adipose lean, overweight, obese individuals analyze effect weight loss. Subjects Methods: Plasma were measured 77 volunteers. obtained from 12 women...
Betatrophin is a secreted protein recently involved in β-cell replication with potential role type 2 diabetes mellitus (T2D).The aim of the present study was to compare circulating concentrations betatrophin human obesity and T2D.Serum were measured by ELISA 153 subjects: 75 obese normoglycemic subjects (OB-NG), 30 impaired glucose tolerance (OB-IGT), 15 T2D (OB-T2D) matched sex, age, body adiposity, comparison 33 lean individuals (LN-NG).Circulating levels significantly decreased further...
GPR55 is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) its only known endogenous ligand. We investigated 1) whether expressed in fat liver; 2) the correlation of both LPI with several metabolic parameters; 3) actions on human adipocytes. analyzed CB1, CB2, gene expression circulating levels two independent cohorts obese lean subjects, normal or impaired glucose tolerance type 2 diabetes. Ex vivo experiments were used to measure intracellular calcium lipid...