A5091244822- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Renal Diseases and Glomerulopathies
- Dermatology and Skin Diseases
- Congenital gastrointestinal and neural anomalies
- Eosinophilic Esophagitis
- Gut microbiota and health
- Chronic Kidney Disease and Diabetes
- Genetics and Physical Performance
- Platelet Disorders and Treatments
- Digestive system and related health
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Probiotics and Fermented Foods
- Inflammatory Bowel Disease
- Adipokines, Inflammation, and Metabolic Diseases
- IL-33, ST2, and ILC Pathways
- Cervical Cancer and HPV Research
- Influenza Virus Research Studies
- Microbial Metabolites in Food Biotechnology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Autoimmune Bullous Skin Diseases
- Metabolism, Diabetes, and Cancer
- Autoimmune and Inflammatory Disorders
Vall d'Hebron Institut de Recerca
2014-2025
Hospital Universitario Severo Ochoa
2025
Biomedical Research Institute of Lleida
2007-2024
Hôpital Robert-Debré
2024
University of Oxford
2005-2023
Institut d'Investigació Biomèdica de Girona
2014-2022
University Hospital Heidelberg
2017-2022
Instituto de Investigación Sanitaria del Principado de Asturias
2021-2022
Instituto de Salud Carlos III
2019-2022
Heidelberg University
2014-2022
<b>Background:</b> Increased numbers of mast cells and cell activation in distal gut segments are associated with symptom onset severity irritable bowel syndrome (IBS). Although upper symptoms common, have not been thoroughly evaluated proximal IBS patients. <b>Methods:</b> Jejunal biopsies obtained by Watson’s capsule, aspiration intestinal fluid one blood sample were 20 diarrhoea-predominant patients (D-IBS) 14 healthy volunteers (H). Psychological stress (Holmes-Rahe Scale) depression...
<h3>Objective</h3> Functional dyspepsia (FD) is an extremely common functional gastrointestinal disorder, the pathophysiology of which poorly understood. We hypothesised that impaired intestinal barrier function involved in onset and persistence this disorder by inducing low-grade inflammation. Therefore, our aim was to evaluate duodenal mucosal integrity inflammation patients with FD. <h3>Design</h3> Duodenal biopsy specimens were obtained from 15 FD fulfilling Rome III criteria age-...
OBJECTIVEThis study sought to identify the profile of circulating microRNAs (miRNAs) in type 2 diabetes (T2D) and its response changes insulin sensitivity.
<h3>Objective</h3> Recently, the authors demonstrated altered gene expression in jejunal mucosa of diarrhoea-predominant irritable bowel syndrome patients (IBS-D); specifically, showed that genes related to mast cells and intercellular apical junction complex (AJC) were expressed differently than healthy subjects. The aim here was determine whether these alterations are associated with structural abnormalities AJC their relationship cell activation IBS-D clinical manifestations....
Bone has recently been described as exhibiting properties of an endocrine organ by producing osteocalcin that increases insulin sensitivity and secretion in animal models.We aimed to evaluate circulating association with three different studies nondiabetic subjects: one cross-sectional study 149 men (using minimal model), two longitudinal independent groups (one formed 26 women, the other 9 11 women), after a mean 7.3 16.8% weight loss, 8.7% loss plus regular exercise.In study, was...
BACKGROUND AND AIM Studies have identified abnormal characteristics of the gut microbiota in patients with active IBD, but whether changes are causal or secondary to inflammation remains uncertain. We investigated dynamics fecal ulcerative colitis (UC) during remission by genomic technology. PATIENTS METHODS Patients clinical and on stable maintenance mesalazine therapy were recruited (N = 33). Fecal samples collected at regular intervals over a period 1 yr. Sixteen who remained eight...
Diarrhea-predominant irritable bowel syndrome (IBS-D) patients show altered epithelial permeability and mucosal micro-inflammation in both proximal distal regions of the intestine. The objective this study was to determine molecular events mechanisms clinical role upper small intestinal alterations.Clinical assessment a jejunal biopsy obtained IBS-D healthy subjects. Routine histology immunohistochemistry performed all participants assess number mast cells (MCs) intraepithelial lymphocytes....
INTRODUCTION Severe diarrhea may complicate pelvic radiotherapy and force interruption of treatment. As there is no current clinical or experimental information on the role gut microbiota in this pathogenesis, we conducted a pilot observational study fecal patients receiving radiotherapy. METHODS The involved 10 who underwent 5 wk for abdominal tumors controls. Four samples were collected from each individual: before, during, at end, 2 after Following amplification bacterial 16S rRNA gene...
The interaction of commensal bacteria with the intestinal immune system is an essential factor in development inflammatory bowel disease (IBD). study isolated bacteria's effects on mucosal response might be relevant for a better understanding pathophysiological mechanisms IBD.We investigated responses to signals from Escherichia coli ATCC 35345 and probiotic Lactobacillus casei DN-114 001 Crohn's (CD) mucosa. Ileal specimens were obtained during surgery CD patients. Mucosal explants...
<h3>Objective</h3> Micro-RNAs (miRNAs) play a crucial role in controlling intestinal epithelial barrier function partly by modulating the expression of tight junction (TJ) proteins. We have previously shown differential messenger RNA (mRNA) correlated with ultrastructural abnormalities patients diarrhoea-predominant IBS (IBS-D). However, participation miRNAs these mRNA-associated findings remains to be established. Our aims were (1) identify differentially expressed small bowel mucosa IBS-D...
The etiopathogenesis of the irritable bowel syndrome (IBS), one most prevalent gastrointestinal disorders, is not well known. accepted hypothesis that IBS result disturbance 'brain-gut axis.' Although pathophysiological mechanisms intestinal dysfunction are complex and completely understood, stress, infections, gut flora, altered immune response thought to play a role in development. barrier, composed single-cell layer, forms physical barrier separates lumen from internal milieu. loss...
<h3>Background and aims</h3> Altered intestinal barrier is associated with immune activation clinical symptoms in diarrhoea-predominant IBS (IBS-D). Increased mucosal antigen load may induce specific responses; however, local antibody production its contribution to aetiopathogenesis remain undefined. This study evaluated the role of humoral activity IBS-D. <h3>Methods</h3> A single jejunal biopsy, luminal content blood were obtained from healthy volunteers (H; n=30) IBS-D (n=49; Rome III...
Plastic pollution is a global problem. Animals and humans can ingest inhale plastic particles, with uncertain health consequences. Nanoplastics (NPs) are particles ranging from 1 nm to 1000 that result the erosion or breakage of larger debris, be highly polydisperse in physical properties heterogeneous composition. Potential effects NPs exposure may associated alterations xenobiotic metabolism, nutrients absorption, energy cytotoxicity, behavior. In humans, no data on absorptions has been...
<h3>Objective</h3> This study aimed to analyze the prognostic factors for overall and progression-free survival in patients with vulvar cancer. <h3>Methods</h3> international, multicenter, retrospective included 2453 diagnosed cancer at 100 different institutions. Inclusion criteria were institutional review board approval from each collaborating center, pathologic diagnosis of invasive carcinoma vulva, primary treatment performed participating center. Patients intraepithelial neoplasia or...
Abstract Background Secondary hyperparathyroidism (SHPT) is a complication of chronic kidney disease (CKD) and associated with changes in calcium phosphate. These related have been increased cardiovascular mortality CKD progression. It not clear whether negative outcomes linked to SHPT are confounded by such factors. The present study was designed assess the possible independent effects [defined as patients excessive parathyroid hormone (PTH) levels or on treatment PTH-reducing agents] risk...
VP2 is the major component of canine parvovirus (CPV) capsids. The VP2-coding gene was engineered to be expressed by a recombinant baculovirus under control polyhedrin promoter. A transfer vector that contains lacZ p10 promoter used in order facilitate selection recombinants. found structurally and immunologically indistinguishable from authentic VP2. shows also capability self-assemble, forming viruslike particles similar size appearance CPV virions. These have been immunize dogs different...
The purpose of this randomized controlled trial was to determine the effects an 8-week (aerobic+strength) exercise training program (3 sessions/week) on circulating cytokine levels breast cancer survivors. We randomly allocated 16 female survivors (mean±SD age: 50±5 years) intervention or usual care (control) group (N=8 in each group). followed consisting 3 sessions/week (session duration: 90 min). measured following cytokines before and after intervention: beta-NGF, CTACK, eotaxin, FGF...
Abstract Background Intestinal epithelial dysfunction is a common pathophysiologic feature in irritable bowel syndrome (IBS) patients and might be the link to its clinical manifestations. We previously showed that chronic psychosocial stress induces jejunal barrier dysfunction; however, whether this response gender‐specific thus explain enhanced female susceptibility IBS remains unknown. Methods responses acute were compared age‐matched groups of healthy women men ( n = 10 each) experiencing...
Background and objectives The prognostic value of mesangial C4d deposits in IgA nephropathy has been analyzed patients with reduced GFR but not those normal kidney function. main objective the study was to analyze association response treatment GFR. Design, setting, participants, & measurements This retrospective cohort included 190 idiopathic diagnosed by biopsy between 1988 2005. had GFR≥80 ml/min per 1.73 m 2 at time diagnosis, they a paraffin-embedded eight glomeruli available....
Background and goal Diarrhoea‐predominant irritable bowel syndrome (IBS‐D) exhibits intestinal innate immune mucosal mast cell (MC) activation. MC stabilisers have been shown to improve IBS symptoms but the mechanism is unclear. Our primary aim was investigate effect of oral disodium cromoglycate (DSCG) on jejunal activation specific signalling pathways in IBS‐D, secondarily, its potential clinical benefit. Study Mucosal (by ultrastructural changes, tryptase release gene expression) protein...