A5004171353- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- Cardiac Imaging and Diagnostics
- Lung Cancer Treatments and Mutations
- Cardiac Arrhythmias and Treatments
- Immunodeficiency and Autoimmune Disorders
- Cutaneous lymphoproliferative disorders research
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Cardiac tumors and thrombi
Hospital Universitari Germans Trias i Pujol
2016-2025
Universitat Autònoma de Barcelona
2015-2024
Josep Carreras Leukaemia Research Institute
2014-2023
Massachusetts General Hospital
2023
Institut Català d'Oncologia
2014-2022
Institute for Biomedicine
2020
University of Coimbra
2019
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2018
Fundación Josep Carreras Contra la Leucemia
2016-2017
Plastic pollution is a global problem. Animals and humans can ingest inhale plastic particles, with uncertain health consequences. Nanoplastics (NPs) are particles ranging from 1 nm to 1000 that result the erosion or breakage of larger debris, be highly polydisperse in physical properties heterogeneous composition. Potential effects NPs exposure may associated alterations xenobiotic metabolism, nutrients absorption, energy cytotoxicity, behavior. In humans, no data on absorptions has been...
Background Acute myeloid leukemia (AML) is a hematopoietic malignancy which biologically, phenotypically and genetically very heterogeneous. Outcome of patients with AML remains dismal, highlighting the need for improved, less toxic therapies. Chimeric antigen receptor T-cell (CART) immunotherapies refractory or relapse (R/R) are challenging because absence universal pan-AML target shared expression antigens normal stem/progenitor cells (HSPCs), may lead to life-threating on-target/off-tumor...
CD19-directed immunotherapies have revolutionized the treatment of advanced B-cell acute lymphoblastic leukemia (B-ALL). Despite initial impressive rates complete remission (CR) many patients ultimately relapse. Patients with B-ALL successfully treated T cells eventually relapse, which, coupled early onset CD22 expression during development, suggests that preexisting CD34+CD22+CD19- (pre)-leukemic represent an "early progenitor origin-related" mechanism underlying phenotypic escape to...
ABSTRACT Mantle cell lymphoma is a rare type of B‐cell lymphoma, which considered incurable yet treatable. In recent years, the treatment options mantle have multiplied, and focus expected to shift from traditional chemoimmunotherapy toward precision medicine. However, this development hindered by high costs targeted therapies. To provide baseline for future assessment benefits new emerging MCL treatments, we established predictive simulated model lifetime trajectories based on retrospective...
Background CD43 has been used on histological samples for the differential diagnosis of lymphoproliferative disorders but there is scarce data its use by flow cytometry (FC). We set out to characterize expression FC in B‐cell and determine possible role these malignancies. Methods analyzed clonal with exclusive peripheral blood and/or bone marrow involvement based their Moreau chronic lymphocytic leukemia (CLL) score particular emphasis CLL 3 (MS3) cases, which often present a diagnostic...
Abstract The use of non‐pegylated liposomal doxorubicin (Myocet ® ) in diffuse large B‐cell lymphoma (DLBCL) has been investigated retrospective and single‐arm prospective studies. This was a phase 2 trial DLBCL patients ≥60 years old with left ventricular ejection fraction (LVEF) ≥55% randomized to standard R‐CHOP or investigational R‐COMP (with Myocet instead conventional doxorubicin). primary end point evaluate the differences subclinical cardiotoxicity, defined as decrease LVEF <55%...
Follicular lymphoma is characterized by a good response to immunochemotherapy (ICT). However, small percentage of patients responds poorly treatment and seems have worse outcome. This study attempted identify the predictive factors outcome refractoriness first-line ICT. All diagnosed with stage II IV follicular between 2002 2014 treated ICT in 4 Spanish institutions were analyzed. Those no or progression relapse within 6 months assessment considered refractory. Three hundred forty-three...
Classical Hodgkin lymphoma (cHL) is a non-AIDS-defining cancer with good response to chemotherapy in the combined antiretroviral therapy (cART) era. The aim of present study was compare characteristics, treatment and survival advanced-stage cHL treated adriamycin, bleomycin, vinblastine dacarbazine (ABVD) between cART-treated HIV-positive HIV-negative patients.We retrospectively analyzed patients from single institution, uniformly ABVD. All received cART concomitantly ABVD.A total 69 were...
Summary Mantle cell lymphoma (MCL) is a rare peripheral B‐cell characterised by eventual relapse and progression towards more aggressive disease biology. With the introduction of rituximab‐ cytarabine‐based immunochemotherapy regimens, prognosis has changed dramatically over last two decades. To assess real‐world survival patients with MCL, we used population‐based cohort 564 MCL who were diagnosed treated between 2000 2020. Patient data collected from seven Finnish treatment centres one...
The concept of borderline lymphoproliferative disorder (LPD) has not been clearly defined.This study aimed to classify patients with leukemic LPD (n = 597, excluding hairy cell leukemia, mantle lymphomas, and CD10-positive LPDs) into CLL or non-CLL applying three diagnostic strategies (the D'Arena CLLflow scores CD43 expression) better characterize unclassified patients.Patients concurring CLL-like 441) like 99) results the were determined have non-CLL, respectively. Patients discordant 57)...
Summary Follicular lymphoma (FL) is the most common indolent lymphoma. Currently there are many comparable treatment options available for FL. When selecting optimal therapy it important to consider possible late effects of as well survival. Secondary haematological malignancy (SHM) a severe effect treatments, but incidence SHMs still largely unknown. The goal present study was determine and how therapeutic decisions interfere with this risk. included 1028 FL patients median follow‐up time...
Abstract Background There are few reports of clinical practice treatment patterns and efficacy in mantle cell lymphoma (MCL). Materials Methods We retrospectively studied a large, multicenter, cohort patients with MCL diagnosed between 2000 2020 eight institutions. Results 536 were registered (73% male, median 70 years). Front‐line was based on high‐dose cytarabine, bendamustine, anthracyclines 42%, 12%, 15%, respectively. The PFS for all 45 months; 68, 34, 30 months those who received...
Abstract Background Within the hematopoietic compartment, fibromodulin (FMOD) is almost exclusively expressed in chronic lymphocytic leukemia (CLL) lymphocytes. We set out to determine whether FMOD could be of help diagnosing borderline lymphoproliferative disorders (LPD). Methods established 3 flow cytometry‐defined groups (CLL [ n = 65], LPD 28], broadly defined as those with CLLflow score between 35 and −20 or discordant CD43 CLLflow, non‐CLL 40]). expression levels were determined by...
Background The life expectancy of patients with follicular lymphoma (FL) has improved considerably since the introduction rituximab. This study examined proportion deaths from progressive and impact FL on survival compared that in general population. Methods Altogether, 749 grades 1 2 9 institutions between 1997 2016 were enrolled. Competing risk models used to estimate cumulative incidences other reasons. Excess mortality was analyzed respect corresponding background populations...
Aim The purpose of the study was to evaluate clinical impact fluorodeoxyglucose‐positron emission tomography/computed tomography (FDG‐PET/CT) followed by a new biopsy from site with maximum standardized uptake value (SUVmax) in case high maximal SUV values, detecting clinically unsuspected histologic transformations (HT) follicular lymphoma (FL). Methods This retrospective included all patients who had undergone FDG‐PET/CT during primary diagnosis or relapse FL between 2010 and 2020 at Oulu...