A5042480143- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Lymphoma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Redox biology and oxidative stress
- Cancer, Lipids, and Metabolism
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Risks and Factors
- Ovarian cancer diagnosis and treatment
- HER2/EGFR in Cancer Research
- BRCA gene mutations in cancer
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Pancreatic and Hepatic Oncology Research
- Genetic Associations and Epidemiology
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Advanced Breast Cancer Therapies
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Neuroendocrine Tumor Research Advances
- Epigenetics and DNA Methylation
Helsinki University Hospital
2004-2025
University of Helsinki
2004-2025
Oulu University Hospital
2013-2024
Northern Ostrobothnia Hospital District
2019-2024
University of Oulu
2012-2021
Institute for Molecular Medicine Finland
2020
Society of Thoracic Surgeons
2017
Valve (United States)
2017
Emory and Henry College
2017
Kuopio University Hospital
2016
8-Hydroxydeoxyguanosine (8-oxodG) is the commonly used marker of oxidative stress-derived DNA damage. 8-OxodG formation regulated by local antioxidant capacity and repair enzyme activity. Earlier studies have reported contradictory data on function 8-oxodG as a prognostic factor in different cancer types.
Disease outcomes of HER2+ breast cancers have dramatically improved after targeted therapies, such as trastuzumab became available. The main mechanism action depends on immunoactivation, while immunosuppressive tumour phenotype has been linked to adverse outcomes. Current study included metastatic cancer patients treated with (n = 40). Immunohistochemistry was conducted detect nitric oxide synthase 2 (iNOS) expressing M1 polarized and CD163
Gut microbiome–derived nanoparticles, known as bacterial extracellular vesicles (bEVs), have garnered interest promising tools for studying the link between gut microbiome and human health. The diverse composition of bEVs, including their proteins, mRNAs, metabolites, lipids, makes them useful investigating diseases such cancer. However, conventional approaches alone may not be accurate in deciphering host–gut communication. In clinical research, there is a gap knowledge on role bEVs solid...
Triple-negative breast cancer (TNBC) and basal-like (BLBC) are subtypes with an especially poor prognosis. 8-Hydroxydeoxyguanosine (8-OHdG) is a widely used marker of oxidative stress the redox-state-regulating enzymes peroxiredoxins (PRDXs) efficient at depressing excessive reactive oxygen species. NF-E2-related factor 2 (Nrf2) Kelch-like ECH-associated protein 1 (Keap1) redox-sensitive transcription factors that regulate PRDX expression. This first study to assess or cell redox...
Objectives: Previous studies have suggested the importance of reactive oxygen species in all steps carcinogenesis. Antioxidant enzymes are considered as most specific and efficient way to protect cells from species. The purpose current study was identify role oxidative stress major antioxidant ovarian carcinomas. Methods: material consisted 68 invasive carcinomas which were studied by immunohistochemistry with antibodies peroxiredoxins (Prxs) I-VI thioredoxin markers nitrotyrosine...
To clarify the role of oxidative stress during breast carcinogenesis by studying expression 8-hydroxydeoxyguanosine (8-OHdG) (a marker DNA damage) and 4-hydroxy-2-nonenal (HNE) lipid peroxidation) different phases carcinogenesis.The study material consisted a total 219 patients: 31 with usual ductal hyperplasia (UDH), 25 atypical (ADH), 30 carcinoma in situ (DCIS) 133 invasive carcinoma. The 8-OHdG HNE were evaluated immunohistochemically. Both (77.4%) (45.8%) was already seen UDH lesions....
Aims: To evaluate the biological roles and prognostic significance of epithelial–mesenchymal transition (EMT)‐mediating transcription factors (TFs) Twist, ZEB1 Slug in patients with diffuse large B‐cell lymphoma (DLBCL). EMT has been shown to enhance solid tumour metastasis, invasion, proliferation. Methods results: Expression was evaluated immunohistochemically eight samples from reactive lymphoid tissues diagnostic 102 DLBCL treated curative intent R‐CHOP‐type chemotherapy. expression...
This study aimed to assess current treatment strategies for metastatic triple-negative breast cancer (mTNBC) and the perceptions of clinical experts in Sweden, Denmark, Norway, Finland, Iceland, comparing them international guidelines provide insights into how these therapies are implemented adapted national Nordic guidelines. A three-round modified Delphi method was followed with consensus defined as 70% agreement. steering committee selected 20 experienced oncologists panellists developed...
Hodgkin lymphoma treatments are largely based on the generation of reactive oxygen species, but increased expression antioxidant enzymes may contribute to chemoresistance. The aims this study were: define extent and prognostic value oxidative stress marker enzyme in lymphomas; investigate a potential association between chemoresistance.We immunohistochemically assessed peroxiredoxin (Prx) II, Prx III, V, VI, manganese superoxide dismutase (MnSOD), 8-hydroxydeoxyguanosine (8-OHdG)...
Toll-like receptor 9 (TLR9) is a cellular DNA-receptor of the innate immune system that widely expressed in cancers. We demonstrated low tumor TLR9 expression predicts poor disease-specific survival triple negative breast cancer (TNBC) and renal cell carcinoma (RCC). hypothesized this because affects immunophenotype. To begin to test this, we compared number infiltrating CD8+ T lymphocytes with treatment naïve (n = 197) RCC 94) cohorts known status. lymphocyte counts were assayed image...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma with increased expression of tenascin C and fibronectin. Their role tumor-stroma ratio in PDAC are not well known. The aim this study was to evaluate fibronectin their prognostic relevance PDAC.Ninety-five resected PDACs were immunohistochemically stained for fibronectin, the separately assessed tumor bulk front. Tumor-stroma determined sections hematoxylin-eosin.Tenascin abundantly expressed PDAC, but absent...
Interleukin (IL)-8 is a proinflammatory cytokine, and high levels of IL-8 are associated with poor prognosis in many malignancies. The objective this study was to explore the clinical benefit monitoring plasma during breast cancer chemotherapy. We conducted an exploratory analysis several circulating proteins, including IL-8, plasma. Plasma samples were obtained from 58 metastatic patients who took part prospective phase 2 first-line bevacizumab chemotherapy trial. Samples analyzed before...