A5085965834- Lymphoma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Neurogenetic and Muscular Disorders Research
- Viral-associated cancers and disorders
- Prenatal Screening and Diagnostics
- Cancer, Lipids, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Glutathione Transferases and Polymorphisms
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- ATP Synthase and ATPases Research
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Multiple Sclerosis Research Studies
- Glioma Diagnosis and Treatment
- Redox biology and oxidative stress
- RNA modifications and cancer
- Cutaneous lymphoproliferative disorders research
Kuopio University Hospital
2001-2024
University of Eastern Finland
2016-2022
Hodgkin lymphoma treatments are largely based on the generation of reactive oxygen species, but increased expression antioxidant enzymes may contribute to chemoresistance. The aims this study were: define extent and prognostic value oxidative stress marker enzyme in lymphomas; investigate a potential association between chemoresistance.We immunohistochemically assessed peroxiredoxin (Prx) II, Prx III, V, VI, manganese superoxide dismutase (MnSOD), 8-hydroxydeoxyguanosine (8-OHdG)...
Epigenetic regulators, including Jumonji domain 2 (JMJD2/KDM4) proteins are involved in post-translational modification of histone demethylation and have a major role carcinogenesis many solid tumors.We assessed immunohistochemically the expression lysine (K)-specific demethylase 4 (KDM4)A, KDM4B KDM4D tumors from 91 patients adriamycin, bleomycin, vinblastine, darcabazine (ABVD)-treated classical Hodgkin lymphoma.Strong cytoplasmic reactive cellular infiltrate also Reed-Sternberg (RS) cells...
Primary central nervous system lymphoma is a rare but aggressive brain malignancy. It associated with poor prognosis even the current standard of care. The aim this study was to evaluate effect and tolerability blood–brain barrier disruption treatment combined high-dose autologous stem cell transplantation as consolidation on primary patients. We performed prospective phase II for 25 patients previously untreated lymphoma. initiated 3–4 weeks after MATRix regimen using optimized therapy...
Hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain (PHD) proteins control cellular oxygen homeostasis a wide range of other processes.We immunohistochemically assessed the expression HIF1α, HIF2α, PHD1, PHD2 PHD3 in 115 cases classical Hodgkin's lymphoma, all treated first line with doxorubicin, bleomycin, vinblastine darcabazine (ABVD) chemotherapy.In advanced-stage patients involved-field radiotherapy (IFRT), nuclear HIF1α reactive infiltrate predicted prolonged relapse-free...
To investigate the applicability of carrier screening in women undergoing invasive prenatal diagnosis.Prospective study.University-based clinic.Two hundred and fifty-six pregnant women.Gene tests were offered for fragile X syndrome, aspartylglycosaminuria infantile neuronal ceroid lipofuscinosis at time testing.The overall uptake was 92%. Previously unrecognised carriership found 10 women: (7); (2) (1). Fetal genotyping carried out one whose partner also a carrier, woman who to have...
Sirtuins (SIRTs) are a family of histone deacetylases, which widely regulate cellular metabolism and also involved in DNA repair. Rap1-interacting factor 1 (Rif1) O6-alkylguanine alkyltransferase (MGMT) DNA-repair enzymes, may potentially be resistance to treatment classical Hodgkin lymphoma (HL). We assessed the expression levels (previously unstudied) SIRT1, SIRT4, SIRT6, Rif1, MGMT immunohistochemically 85 patients with untreated HL. Aberrant distributions SIRT6 were detected neoplastic...
Introduction: In epidemiological studies, chronic inflammation or previous major infection have revealed to be associated with an increased risk of developing Hodgkin lymphoma (HL). The association the disease outcome is poorly defined. this retrospective study based on 92 consecutive HL patients, we explored incidence inflammatory processes in newly diagnosed patients and their treatment outcome. Methods: Medical history before diagnosis including infection; dental inflammation; cutaneous...