A5008625125- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Cardiovascular Function and Risk Factors
- Chronic Myeloid Leukemia Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Hematological disorders and diagnostics
- Retinoids in leukemia and cellular processes
- Histone Deacetylase Inhibitors Research
- Antimicrobial Resistance in Staphylococcus
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- Viral-associated cancers and disorders
- Metabolism, Diabetes, and Cancer
Kuopio University Hospital
2014-2024
University of Eastern Finland
1997-2000
University College London
1997
Inserm
1997
St Thomas' Hospital
1997
To assess the association between high but nondiabetic blood glucose levels and risk of death from all causes, coronary heart disease (CHD), cardiovascular disease, neoplasms.We studied 20-year mortality non-diabetic, working men, age 44-55 years, in three European cohorts known as Whitehall Study (n = 10,025), Paris Prospective 6,629), Helsinki Policeman 631). These men were identified by their 2-h following an oral tolerance test absence a prior diagnosis diabetes. As protocol for methods...
Abstract —The interpretation of conventional multivariate analyses concerning the relation insulin to risk atherosclerotic disease is complex because correlations with other factors. Therefore, we applied factor analysis study clustering factors in baseline data Helsinki Policemen Study (970 healthy men aged 34 64 years) and investigated whether these clusterings predict coronary heart (CHD) stroke risk. Areas under glucose response curves (AUC AUC insulin) were used reflect levels during...
The Helsinki Policemen Study is one of the first prospective epidemiological studies demonstrating an association hyperinsulinemia to risk coronary heart disease (CHD). aim present study was investigate predictive value with regard CHD during a 22-year follow-up population.The based on cohort 970 men who were 34 64 years age and free CHD, other cardiovascular disease, diabetes. Risk factor measurements at baseline examination included oral glucose tolerance test (OGTT) blood plasma insulin...
OBJECTIVE: To investigate the association of plasma insulin with all-cause, cardiovascular, and noncardiovascular mortality. RESEARCH DESIGN AND METHODS: We studied 22-year mortality data from Helsinki Policemen Study The study population comprised 970 men, 34-64 years age, who were free coronary heart disease, other cardiovascular diabetes. Area under response curve (AUC insulin) during an oral glucose tolerance test was used to reflect levels. RESULTS: During follow-up period, 276 men...
The BCL-2 inhibitor venetoclax has revolutionized the treatment of acute myeloid leukemia (AML) in patients not benefiting from intensive chemotherapy. Nevertheless, failure remains a challenge, and predictive markers are needed, particularly for relapsed or refractory AML. Ex vivo drug sensitivity testing may correlate with outcomes, but its prospective value unexplored. Here we report results first stage phase II VenEx trial evaluating utility predictiveness using different cell culture...
Background and Purpose —Several studies have shown that hyperinsulinemia is associated with the risk of coronary heart disease, but information on association stroke limited. We investigated during a 22-year follow-up Helsinki Policemen Study population. Methods —The study was based cohort 970 men aged 34 to 64 years who were free cerebrovascular other cardiovascular or diabetes. Risk factor measurements at baseline examination included an oral glucose tolerance test blood plasma insulin 0,...
A significant proportion of patients with lymphoid malignancies are hard-to-mobilize a combination chemotherapy plus granulocyte colony-stimulating factor (G-CSF) (chemomobilization). Plerixafor is novel drug used to improve mobilization blood stem cells. However, it has been studied mainly in association G-CSF mobilization. We evaluated the efficacy 'pre-emptive' use plerixafor after chemomobilization who seem mobilize poorly. During 15 month period, altogether 63 were admitted our...
BACKGROUND Autologous stem cell transplantation is commonly used to treat non‐Hodgkin's lymphomas (NHLs). Cellular composition of the blood grafts apparently has a role in posttransplant hematologic and immune recovery. Plerixafor increases mobilization CD34+ cells higher amounts various lymphocyte subsets have been reported grafts. Limited prospective data are available regard graft cellular composition, recovery, patient outcomes NHL patients who receive plerixafor added chemomobilization....
Autologous stem cell transplantation (auto-SCT) is an established treatment option in patients with non-Hodgkin lymphoma (NHL). In this prospective multicenter study, the effect of infused blood graft cellular composition on post-transplant outcome was analyzed 129 NHL patients. Higher CD34+ content (>2.5 × 106/kg) correlated better progression-free survival (PFS) (p=.009) and overall (OS) (p=.004). CD34+CD133+CD38– counts (>0.08 were also linked PFS (p=.03) OS (p=.004), these benefits...
Abstract Background Autologous stem cell transplantation (auto‐SCT) is a widely used treatment option in multiple myeloma (MM) patients. The optimal graft cellular composition not known. Study design and methods Autograft was analyzed after freezing by flow cytometry 127 MM patients participating prospective multicenter study. impact of on hematologic recovery outcome auto‐SCT evaluated. Results A higher CD34 + content predicted faster platelet both the short long term. In with standard‐risk...
BACKGROUND Autologous stem cell transplantation is an established treatment option for patients with multiple myeloma (MM) or non‐Hodgkinʼs lymphoma (NHL). STUDY DESIGN AND METHODS In this prospective multicenter study, 147 MM were compared 136 NHL regarding the mobilization and apheresis of blood CD34+ cells, cellular composition infused grafts, posttransplant recovery, outcome. RESULTS Multiple mobilized cells more effectively (6.3 × 10 6 /kg vs. 3.9 /kg, p = 0.001). The proportion poor...
Abstract Background Diffuse large B‐cell lymphoma (DLBCL) is a common indication for autologous stem cell transplantation (auto‐SCT). Study Design and Methods This prospective noninterventional study aimed to evaluate the impact of mobilization characteristics graft cellular content on hematologic recovery outcome after auto‐SCT among 68 patients with DLBCL. Results Better capacity as manifested by blood CD34 + count >32 × 10 6 /L yield first apheresis >2.75 /kg correlated faster...
Primary central nervous system lymphoma is a rare but aggressive brain malignancy. It associated with poor prognosis even the current standard of care. The aim this study was to evaluate effect and tolerability blood–brain barrier disruption treatment combined high-dose autologous stem cell transplantation as consolidation on primary patients. We performed prospective phase II for 25 patients previously untreated lymphoma. initiated 3–4 weeks after MATRix regimen using optimized therapy...
SUMMARY Background Approximately 20% of patients with a recurrently poor platelet transfusion increment show human leukocyte antigen ( HLA ) alloantibodies. The aim this study was to analyse the impact mean fluorescence intensity MFI levels donor‐specific antibodies and feasibility HLAMatchmaker algorithm in donor selection. Study design methods A total 270 ‐typed responses 40 were included study. patients' immunisation status determined Luminex‐based methods, alloantibody strengths defined...
The composition of autologous blood grafts after cryopreservation, post-transplant hematological recovery up to 1 year and immune 6 months as well outcome was analyzed in 87 patients with multiple myeloma (MM). receiving added plerixafor due poor mobilization (11%) were compared those mobilized G-CSF or cyclophosphamide (CY) plus G-CSF. use found significantly affect the graft there a higher proportion more primitive CD34+ cells, number T B lymphocytes NK cells who received also plerixafor....
Abstract Objectives To evaluate quick Sequential Organ Failure Assessment (qSOFA) score during febrile neutropenia (FN) in adult patients receiving intensive chemotherapy for acute myeloid leukemia (AML). Methods qSOFA score, as well the association of with ICU admission, infectious mortality, blood culture findings, and C‐reactive protein (CRP) measurements FN were assessed among 125 AML 355 periods a tertiary care hospital from November 2006 to December 2018. Results The multivariate model...
Abstract Background Prospective data on the impact of CD34 + cell loss during cryopreservation and amount cryopreserved cells infused after high‐dose therapy hematologic recovery post‐transplant outcome in multiple myeloma (MM) are scarce. Patients methods This post‐hoc study aimed to investigate factors associating with effects infusion a very low number (<1.0 × 10 6 /kg, group A), (1–1.9 B), optimal (≥2 C) thawed viable recovery, progression free survival, overall survival autologous...