Arto Mannermaa
A5075338726- Alzheimer's disease research and treatments
- BRCA gene mutations in cancer
- Dementia and Cognitive Impairment Research
- Genetic Associations and Epidemiology
- Cancer Cells and Metastasis
- AI in cancer detection
- Cancer Genomics and Diagnostics
- Bioinformatics and Genomic Networks
- Pregnancy and preeclampsia studies
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- Genomics and Rare Diseases
- Breast Cancer Treatment Studies
- Cholinesterase and Neurodegenerative Diseases
- Prenatal Screening and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Genomic variations and chromosomal abnormalities
- Hemoglobinopathies and Related Disorders
- Global Cancer Incidence and Screening
- MicroRNA in disease regulation
- Birth, Development, and Health
- Proteoglycans and glycosaminoglycans research
University of Eastern Finland
2015-2025
Kuopio University Hospital
2012-2024
Finland University
2012-2024
Biogen (United States)
2023
Translational Research in Oncology
2022
Institute of Clinical Research
2022
Eastern Finland Laboratory Center
2013
University of Helsinki
2012
Vaasa Central Hospital
2012
Tampere University Hospital
2004
Background: Presence of the apolipoprotein E (apoE) ε4 allele, which is involved in cholesterol metabolism, most important genetic risk factor for Alzheimer disease. Elevated midlife values total level and blood pressure have been implicated recently as factors Objective: To study relative importance putative relationship among apoE level, late-life Design: Prospective population-based study. Setting: Kuopio Joensuu, eastern Finland. Participants: Participants were derived from random...
ABSTRACT Population isolates such as Finland provide benefits in genetic studies because the allelic spectrum of damaging alleles any gene is often concentrated on a small number low-frequency variants (0.1% ≤ minor allele frequency < 5%), which survived founding bottleneck, opposed to being distributed over much larger ultra--rare variants. While this advantage well-- established Mendelian genetics, its value common disease genetics has been less explored. FinnGen aims study genome and...
<i>Background: </i>Mild cognitive impairment (MCI) has attracted considerable interest as a potential predictor of Alzheimer’s disease (AD). Both the apolipoprotein E (ApoE) &#917;4 allele and vascular factors have been associated with higher risk for AD, recently they also linked to MCI. <i>Objectives: </i>To estimate incidence MCI among cognitively healthy elderly subjects during 3-year follow-up, evaluate impact demographic well ApoE on conversion...
Epithelial-mesenchymal transition (EMT) in cells is a developmental process adopted during tumorigenesis that promotes metastatic capacity. In this study, we advance understanding of EMT control cancer with the description novel vimentin-ERK axis regulates transcriptional activity Slug (SNAI2). Vimentin, ERK, and exhibited overlapping subcellular localization clinical specimens triple-negative breast carcinoma. RNAi-mediated ablation these gene products inhibited cell migration invasion...
Previous in vitro studies have suggested interactions between hyaluronan (HA), CD44 and HER2. We studied the expression of HA a material 278 breast cancer cases, half which were HER2-positive. Intense stromal staining was associated with HER2 positivity, large tumor size, lymph node hormone receptor negativity, poor differentiation, high body mass index, increased relapse rate shortened overall survival. Among 139 HER2-positive intensity as most relapses occurred cases intense staining. The...
Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or time, genotype, may be causally overall, pre/post-menopause, case-groups defined tumour characteristics.
OBJECTIVES--The epsilon 4 allele of apolipoprotein E (ApoE) is a risk factor for late onset Alzheimer9s disease. ApoE present in senile plaques, neurofibrillary tangles, and cerebrovascular amyloid, it implicated synaptogenesis. The effect polymorphism on the volumes hippocampus, amygdala, frontal lobe was studied. hypothesis that patients with disease carrying have more pronounced atrophy. relation cerebral blood flow cortical areas also assessed. METHODS--Fifty eight at early stage 34...
A causative association between diabetes mellitus (DM) and Alzheimer's disease (AD) has been suggested based on clinical epidemiological studies. One hypothesis is that the link DM AD related to function of insulin-degrading enzyme (IDE), an degrades not only insulin pancreatic amylin but also beta-amyloid (Abeta). Thus, in diabetics, Abeta might compete for IDE this lead increase Abeta. The objective study was test hyperinsulinaemia can elevate levels thus contribute pathology...
Abstract NRF2 activates several protective genes, such as sulfiredoxin (SRXN1), a response to oxidative and xenobiotic stress. Defects in pathway may increase cancer susceptibility. In tumor cells, activation of lead chemo- radioresistance thus affect patient outcome. Nine single-nucleotide polymorphisms on gene eight SRXN1 were genotyped 452 patients with breast 370 controls. Protein expression was studied 373 carcinomas by immunohistochemistry. Statistical significance the associations...
Abstract Background Reproductive factors have been shown to be differentially associated with risk of estrogen receptor (ER)-positive and ER-negative breast cancer. However, their associations intrinsic-like subtypes are less clear. Methods Analyses included up 23 353 cases 71 072 controls pooled from 31 population-based case-control or cohort studies in the Breast Cancer Association Consortium across 16 countries on 4 continents. Polytomous logistic regression was used estimate association...
Tumor-associated macrophages (TAMs) are associated with a poor outcome in breast cancer (BC), but their prognostic value different BC subtypes has remained somewhat unclear. Here, we investigated the of M2-like TAMs (CD163+) and all (CD68+) patient cohort 278 non-metastatic patients, half whom were HER2+ (n = 139). The survival endpoints overall (OS), cancer-specific (BCSS) disease-free (DFS). In whole 278), high CD163+ TAM count CD68+ worse (p ≤ 0.023). BC, was an independent factor for...
The APOE ε4 variant and hippocampal atrophy in Alzheimer's disease Lewy body dementia: a systematic review of magnetic resonance imaging studies therapeutic relevance ,
Abstract Background: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. Methods: We analyzed data for 121,435 women diagnosed with from 67 studies in the Breast Cancer Association Consortium 16,890 deaths (8,554 specific) over 10 years. Cox regression was used to estimate associations between risk and 10-year all-cause mortality cancer–specific overall, estrogen receptor (ER) status, intrinsic-like Results: There no...
Uterine leiomyomata (UL) are the most common tumours of female genital tract and primary cause surgical removal uterus. Genetic factors contribute to UL susceptibility. To add understanding heritable genetic risk factors, we conduct a genome-wide association study (GWAS) in up 426,558 European women from FinnGen previous meta-GWAS. In addition 50 known loci, identify 22 loci that have not been associated with prior studies. UL-associated harbour genes enriched for development, growth,...
<b><i>Objective: </i></b> To examine the relationship between socioeconomic factors and <i>APOE</i> carrier status on development of dementia. <b><i>Methods:</i></b> Subjects were derived from random, population-based samples previously studied in surveys carried out 1972, 1977, 1982, 1987. After an average follow-up 21 years, 1449 (73%) subjects aged 65 to 79 years re-examined 1998. The diagnosis dementia among nonparticipants was patient records local hospitals primary health care clinics....
Background and Purpose Apolipoprotein E (apoE) ε4 allele has been associated with a high risk for coronary heart disease. Increased frequency of the also reported in patients late-onset familial sporadic Alzheimer’s disease (AD). The aim this study was to investigate degree cerebral atherosclerosis neuropathologically verified series AD different apoE genotypes. In addition, we studied relationship between extent β-amyloid (Aβ) accumulation. Methods We 38 subjects (32 definite 6 age-matched...
Epithelial-mesenchymal transition (EMT) is a crucial process in tumorigenesis since tumor cells attain fibroblast-like features enabling them to invade surrounding tissue. Two transcription factors, TWIST and SNAI1, are fundamental regulating EMT. Immunohistochemistry was used study the expression of SNAI1 109 pharyngeal squamous cell carcinomas. Tumors with intense stromal staining relapsed more frequently (p = 0.04). both positive immunoreactivity stroma were at least Stage II 0.05)...
Abstract We propose a novel multi-level dilated residual neural network, an extension of the classical U-Net architecture, for biomedical image segmentation. is most popular deep architecture segmentation, however, despite being state-of-the-art, model has few limitations. In this study, we suggest replacing convolutional blocks with blocks, resulting in enhanced learning capability. also to incorporate non-linear into skip connections reduce semantic gap and restore information lost when...