A5050360866- Protein Degradation and Inhibitors
- Clostridium difficile and Clostridium perfringens research
- Protein Tyrosine Phosphatases
- Microscopic Colitis
- Cell Adhesion Molecules Research
- Healthcare professionals’ stress and burnout
- COVID-19 and Mental Health
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Galectins and Cancer Biology
- Nosocomial Infections in ICU
- Peptidase Inhibition and Analysis
- Family and Patient Care in Intensive Care Units
- Melanoma and MAPK Pathways
- Gut microbiota and health
- Protease and Inhibitor Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Viral gastroenteritis research and epidemiology
- HER2/EGFR in Cancer Research
- Caveolin-1 and cellular processes
- Healthcare Education and Workforce Issues
- Nursing Diagnosis and Documentation
Tampere University
2009-2024
Tampere University Hospital
2009-2024
Pirkanmaa Hospital District
2022-2024
University of Jyväskylä
2022
Turku University of Applied Sciences
2022
Orion Corporation (Finland)
2016-2020
NHS Tayside
2020
Helsinki University Hospital
2007-2019
University of Turku
2009-2019
Turku Centre for Biotechnology
2008-2019
Background During the COVID-19 pandemic, hospital staff have experienced a variety of mental health challenges. European research on anxiety and stress among workers during pandemic is limited. This study aimed to describe levels Finnish pandemic.Methods The multidimensional, cross-sectional survey was distributed all working at two specialized medical care centres in spring 2020 (n = 1,995). Generalized Anxiety Disorder 7-item (GAD-7) scale used measure workers' anxiety.Results total mean...
Abstract Purpose: To investigate the clinical relevance of recently characterized human oncoprotein cancerous inhibitor protein phosphatase 2A (CIP2A) in breast cancer. Experimental Design: CIP2A expression (mRNA and protein) was measured three different sets mammary tumors compared with clinicopathologic variables. The functional role cancer cells evaluated by small interfering RNA–mediated depletion followed an analysis cell proliferation, migration, anchorage-independent growth, xenograft...
Mutations of the tumor suppressor TP53 are present in many forms human cancer and associated with increased cell invasion metastasis. Several mechanisms have been identified for promoting dissemination cells mutations, including targeting integrins to plasma membrane. Here, we demonstrate a role filopodia-inducing motor protein Myosin-X (Myo10) mutant p53-driven invasion. Analysis gene expression profiles from 2 breast data sets revealed that MYO10 was highly expressed aggressive subtypes....
Faecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection (rCDI). The finding of suitable donor, donor screening and preparation faecal transplants are challenging in clinical work.To develop a practical protocol preparing frozen to compare the efficacy previously fresh faeces treating rCDI.Two healthy volunteers acted as universal donors preparations, which were prepared by suspending into physiological saline, adding glycerol final...
Faecal microbiota transplantation (FMT) is used in the treatment of recurrent Clostridium difficile infection. Its success typically attributed to restoration a diverse microbiota. Viruses (including bacteriophages) are most numerically dominant and potentially members microbiota, but their fate following FMT has not been well studied.We studied viral transfer from 3 donors 14 patients. Recipient viromes resembled those for up 12 months. Tracking individual bacteriophage colonisation...
Epithelial-mesenchymal transition (EMT) in cells is a developmental process adopted during tumorigenesis that promotes metastatic capacity. In this study, we advance understanding of EMT control cancer with the description novel vimentin-ERK axis regulates transcriptional activity Slug (SNAI2). Vimentin, ERK, and exhibited overlapping subcellular localization clinical specimens triple-negative breast carcinoma. RNAi-mediated ablation these gene products inhibited cell migration invasion...
Background. Clostridium difficile causes diarrhea that ranges from a benign, self-limiting antibiotic use–associated disease to life-threatening pseudomembranous colitis. has rarely been isolated in extraintestinal infections. Our objective was characterize clinical features and risk factors of these
Vascular endothelial growth factor (VEGF) is a major angiogenic that triggers formation of new vessels under physiological and pathological conditions. However, the mechanisms limit VEGF responses in target cells hence prevent excessive harmful angiogenesis are not well understood. Here, our objective was to study whether T-cell protein tyrosine phosphatase (TCPTP, also known as PTN2), which we found be expressed human cells, could alter signalling by controlling phosphorylation VEGFR2. We...
Summary Background Clostridium difficile can cause severe antibiotic‐associated colitis. Conventional treatments with metronidazole and vancomycin improve symptoms, but after discontinuation of treatment, C. infection ( CDI ) recurs in a number patients. Rifaximin is rifamycin‐based non‐systemic antibiotic that has effect against . Aim To assess the effectiveness rifaximin recurrent infection. Methods We retrospectively evaluated records 32 patients who were treated for The symptoms 12 weeks...
SHARPIN-deficient mice display a multiorgan chronic inflammatory phenotype suggestive of altered leukocyte migration. We therefore studied the role SHARPIN in lymphocyte adhesion, polarization, and found that localizes to trailing edges (uropods) both mouse human chemokine-activated lymphocytes migrating on intercellular adhesion molecule-1 (ICAM-1), which is one major endothelial ligands for leukocytes. cells adhere better ICAM-1 show highly elongated tails when migrating. The increased...
Summary Background Faecal microbiota transplantation ( FMT ) is an effective treatment for recurrent Clostridium difficile infection. In short‐term the has been shown to be safe, however, there are no large, long‐term follow‐up studies looking into potential adverse effects. Aim To analyse effect of in patients with C. infection and compare outcome antibiotic treated patients. Methods Altogether 84 which 45 received a 39 served as controls receiving antibiotics were followed on average 3.8...
Aneuploidy is frequently detected in solid tumors but the mechanisms regulating generation of aneuploidy and their relevance cancer initiation remain under debate are incompletely characterized. Spatial temporal regulation integrin traffic critical for cell migration cytokinesis. Impaired endocytosis, because loss Rab21 small GTPase or mutations β-subunit cytoplasmic tail, induces failure cytokinesis vitro. Here, we describe that repeatedly failed cytokinesis, impaired traffic, sufficient to...
Reports on real-world experience efficacy of bezlotoxumab (BEZ) has been lacking thus far. We retrospectively studied the and safety BEZ in preventing recurrence Clostridium difficile infection (CDI) five university hospitals Finland. Seventy-three percent our 46 patients remained free following 3 months performance as 71% effective also among immunocompromised patients. In severe CDI, prevented 63% cases. From study patients, 78% had three or more known risk factors for CDI. Eight were...
T-cell protein tyrosine phosphatase (TCPTP/TC45) is a ubiquitously expressed intra-cellular non-receptor involved in the negative regulation of several cancer relevant cellular signalling pathways. We have previously shown that interaction between alpha-cytoplasmic tail alpha1beta1 integrin and TCPTP activates by disrupting an inhibitory intra-molecular bond TCPTP. Thus, inhibition regulatory desirable strategy for activation attenuation oncogenic RTK signalling. However, this challenging...
Abstract Purpose: Only few predictive factors for the clinical activity of anti–epidermal growth factor receptor (EGFR) therapy are available. Mammary-derived inhibitor (MDGI) is a small cytosolic protein suggested to play role in differentiation epithelial cells. Here, we have investigated effect MDGI expression on EGFR signaling and cetuximab responsiveness cancer Experimental Design: mRNA was breast lung samples nontransformed malignant cell lines. The ectopic EGFR, ErbB2, integrin...
To identify and differentiate the practice patterns of generalist, specialist advanced nursing roles in central hospital contexts.In Finland, as other Nordic countries, emerged around 2000. There are over 60,000 registered nurses/midwives Finland clinical career pathway from a nurse to has been described yet not fully implemented healthcare organizations. However, number activities nonadvanced practitioner well known.A descriptive comparative study.An online self-report survey was conducted...
Scand J Caring Sci; 2010; 24; 734–745 Support for hospital patients and associated factors Background: During hospitalization need support from nursing staff. To improve the delivery of during hospitalization, it is necessary to know more about how patient background organizational are with patients` perceived access support. Aim: This study describes patients’ emotional informational A further concern associations (e.g. age, education, mode admission) various nurse bed ratio, skill mix)...
On 18 October 2007, the first case of Clostridium difficile PCR ribotype 027-associated disease was detected in Finland.