A5013847668- Wound Healing and Treatments
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Cellular Mechanics and Interactions
- Membrane Separation Technologies
- Skin and Cellular Biology Research
- Electrospun Nanofibers in Biomedical Applications
- Membrane-based Ion Separation Techniques
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Prion Diseases and Protein Misfolding
- Additive Manufacturing and 3D Printing Technologies
- Epigenetics and DNA Methylation
- Silk-based biomaterials and applications
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Solar-Powered Water Purification Methods
- Covalent Organic Framework Applications
- Ferroptosis and cancer prognosis
- Advanced Nanomaterials in Catalysis
- Viral-associated cancers and disorders
- Autophagy in Disease and Therapy
- Chemical Looping and Thermochemical Processes
- Catalytic Processes in Materials Science
Tianjin Chengjian University
2009-2025
Tianjin University of Science and Technology
2025
Sun Yat-sen University
2014-2024
Zhengzhou University of Light Industry
2022-2024
Beihang University
2024
Shanghai Institute of Materia Medica
2024
University of Chinese Academy of Sciences
2022-2024
Nanjing Forestry University
2024
Xinjiang Medical University
2024
Fifth Affiliated Hospital of Xinjiang Medical University
2024
Diabetic wound healing remains a critical challenge due to its vulnerability multidrug-resistant (MDR) bacterial infection, as well the hyperglycemic and oxidative microenvironment. Herein, an injectable multifunctional hydrogel (FEMI) was developed simultaneously overcome these hurdles. The FEMI fabricated through Schiff-based reaction between ε-polylysine (EPL)-coated MnO2 nanosheets (EM) insulin-loaded self-assembled aldehyde Pluronic F127 (FCHO) micelles. Through synergistic combination...
Significance The central concept in this study is that a major cytoskeletal component, vimentin, acts as signal integrator during wound healing, operating both signal-triggering and signal-receiving cells. This previously unreported for intermediate filaments, with an evolving paradigm according to which filaments emerge integrators of regeneration specific functions the particular tissues individual are characteristic. Our reveals underlying molecular cellular control vimentin...
Cellulose nanofibrils (CNFs) in the form of hydrogels stand out as a platform biomaterial bioink formulation for 3D printing because their low cytotoxicity and structural similarity to extracellular matrices. In present study, scaffolds were successfully printed with low-concentration inks formulated by 1 w/v % 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized CNF less than gelatin methacrylate (GelMA). Quartz crystal microbalance dissipation monitoring (QCM-D) measurements...
ABSTRACT The actin and intermediate filament cytoskeletons contribute to numerous cellular processes, including morphogenesis, cytokinesis migration. These two cytoskeletal systems associate with each other, but the underlying mechanisms of this interaction are incompletely understood. Here, we show that inactivation vimentin leads increased stress fiber assembly contractility, consequent elevation myosin light chain phosphorylation stabilization tropomyosin-4.2 (see Geeves et al., 2015)....
Ferroptosis, a form of iron-dependent cell death driven by cellular metabolism and lipid peroxidation, has been implicated as tumor-suppressor function for cancer therapy. Recent advance revealed that the sensitivity to ferroptosis is tightly linked numerous biological processes, including amino acid biosynthesis glutathione. Here, using high-throughput CRISPR/Cas9-based genetic screen in HepG2 hepatocellular carcinoma cells search metabolic proteins inhibiting ferroptosis, we identified...
Here, we report the synthesis of two-dimensional (2D) layered metal-organic framework (MOF) nanoparticle (NP) superstructures via an ice-templating strategy. MOF NP monolayers and bilayers can be obtained by regulating concentration colloidal NPs without any external fields during self-assembly. Adjacent polyhedral are packed aligned through crystalline facets, resulting in formation a quasi-ordered array superstructure. The morphology layers is well preserved when subjected to pyrolysis,...
Existing therapeutics for autoimmune diseases remain problematic due to low efficacy, severe side effects, and difficulties reach target tissues. Herein, we design multifunctional fusion nanovesicles that can lesions the treatment of skin diseases. The grapefruit-derived exosome-like (GEVs) with anti-inflammatory antioxidant effects are first encapsulated CX5461, an immunosuppressant anti-proliferative properties form GEV@CX5461. In order enhance therapeutic efficiency safety, GEV@CX5461...
The actin cytoskeleton and cytoplasmic intermediate filaments contribute to cell migration morphogenesis, but the interplay between these two central cytoskeletal elements has remained elusive. Here, we find that specific stress fiber structures, transverse arcs, interact with vimentin promote their retrograde flow. Consequently, myosin-II-containing arcs are important for perinuclear localization of network in cells. reciprocally restricts movement hence controls width flat lamellum at...
We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, by in situ Ca2+ crosslinking and post-printing chemical with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% hydrogels, their mechanical strength being tunable range 3 8 kPa. Cell tests suggest that 3D-printed BDDE-crosslinked supported fibroblast cells' proliferation, which was improving increasing rigidity. These render a new member...
Epithelial-mesenchymal transition (EMT) in cells is a developmental process adopted during tumorigenesis that promotes metastatic capacity. In this study, we advance understanding of EMT control cancer with the description novel vimentin-ERK axis regulates transcriptional activity Slug (SNAI2). Vimentin, ERK, and exhibited overlapping subcellular localization clinical specimens triple-negative breast carcinoma. RNAi-mediated ablation these gene products inhibited cell migration invasion...
SummaryKaposi sarcoma (KS), an angioproliferative disease associated with Kaposi herpesvirus (KSHV) infection, harbors a diversity of cell types ranging from endothelial to mesenchymal cells unclear origin. We developed three-dimensional model for KSHV infection and used it demonstrate that induces transcriptional reprogramming lymphatic via endothelial-to-mesenchymal transition (EndMT). KSHV-induced EndMT was initiated by the viral proteins vFLIP vGPCR through Notch pathway activation,...
Significance Angiogenesis, the formation of new blood vessels from existing ones, is essential for embryonic development and necessary tumor growth invasion. The Notch signaling pathway regulates angiogenesis where two ligands, Dll4 Jagged 1, exert opposite functions on sprouting. We found that intermediate filament vimentin balances by binding specifically to proangiogenic ligands. This provides a force-generating mechanism Jagged–Notch complex ensure efficient transendocytosis activation....