A5061084760- Cancer, Lipids, and Metabolism
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Psoriasis: Treatment and Pathogenesis
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- RNA modifications and cancer
Sun Yat-sen University
2021-2023
Existing therapeutics for autoimmune diseases remain problematic due to low efficacy, severe side effects, and difficulties reach target tissues. Herein, we design multifunctional fusion nanovesicles that can lesions the treatment of skin diseases. The grapefruit-derived exosome-like (GEVs) with anti-inflammatory antioxidant effects are first encapsulated CX5461, an immunosuppressant anti-proliferative properties form GEV@CX5461. In order enhance therapeutic efficiency safety, GEV@CX5461...
Ferroptosis, iron-dependent cell death, is an established mechanism for cancer suppression, particularly in hepatocellular carcinoma (HCC). Sorafenib (SOR), a frontline drug the treatment of HCC, induces ferroptosis by inhibiting Solute Carrier family 7 member 11 (SLC7A11), with inadequate notably contributing to SOR resistance tumor cells. To further verify biological targets associated analysis Cancer Genome Atlas (TCGA) database was performed find significant co-upregulation SLC7A11 and...