Xiaohong R. Yang
A5038423396- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- BRCA gene mutations in cancer
- Breast Cancer Treatment Studies
- Bone Tumor Diagnosis and Treatments
- Genetic Associations and Epidemiology
- Sarcoma Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Epigenetics and DNA Methylation
- Digital Radiography and Breast Imaging
- Genetic factors in colorectal cancer
- Genomic variations and chromosomal abnormalities
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Estrogen and related hormone effects
- Oral and Maxillofacial Pathology
- Infrared Thermography in Medicine
- Gene expression and cancer classification
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- AI in cancer detection
- Bioinformatics and Genomic Networks
- Breast Lesions and Carcinomas
- Renal Diseases and Glomerulopathies
- Genomics and Rare Diseases
National Cancer Institute
2016-2025
National Institutes of Health
2016-2025
Division of Cancer Epidemiology and Genetics
2014-2024
Hunan Cancer Hospital
2023-2024
Zhangjiakou Academy of Agricultural Sciences
2024
Cancer Institute (WIA)
2021-2024
United States Department of Health and Human Services
2013-2024
Huzhou University
2024
Jiangsu Hengrui Medicine (China)
2024
Central South University
2023
Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone (PR) expression status of the tumors.
Abstract Analysis of gene expression data suggests that breast cancers are divisible into molecular subtypes which have distinct clinical features. This study evaluates whether pathologic features and etiologic associations differ among subtypes. We evaluated 804 women with invasive 2,502 controls participating in a Polish Breast Cancer Study. Immunohistochemical stains for estrogen receptor α, progesterone receptor, human epidermal growth factor receptors (HER2 HER1), cytokeratin 5 were...
A study of nasopharyngeal carcinoma (NPC) families with two or more affected members was conducted in Taiwan (265 2,444 individuals, 502 and 1,942 unaffected) to determine the association between NPC potential etiologic factors high-risk families. Similar results from a previous case-control Taiwan, Guangdong salted fish consumption during childhood, exposure wood, betel nut were all associated elevated risk using conditional logistic regression, although these associations not as strong...
Background:Previous reports suggested that female breast cancer is associated with earlier ages at onset among Asian than Western populations. However, most studies utilized cross-sectional analyses may be confounded by calendar-period and/or birth cohort effects. We, therefore, considered a longitudinal (forward-looking) approach adjusted for changes and conditioned upon cohort.
Abstract Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) identify loci. Findings were replicated in independent (55,789 330,490 controls). identified novel at 1q22 involving breast lung squamous cell carcinoma, eQTL analysis showing an...
Limited evidence, mostly from studies in Western populations, suggests that the prognostic effects of lifestyle-related risk factors may be molecular subtype-dependent. Here, we examined whether pre-diagnostic for breast cancer are associated with clinical outcomes by subtype among patients an understudied Asian population. In this population-based case series, evaluated relation to 10-year all-cause mortality (ACM) and 5-year recurrence 3012 women invasive Sarawak, Malaysia. A total 579...
Our pilot study suggested that noninvasive ventilation (NIV) reduced the need for intubation compared with conventional administration of oxygen on patients "early" stage mild acute respiratory distress syndrome (ARDS, PaO2/FIO2 between 200 and 300). To evaluate whether early NIV can reduce invasive in pneumonia-induced ARDS. Prospective, multicenter, randomized controlled trial (RCT) through a Venturi mask. Primary outcome included numbers who met criteria. Two hundred subjects were to (n =...
Protein truncating variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2 are associated with increased breast cancer risk, but risks missense these genes uncertain. We analyzed data on 59,639 cases 53,165 controls from studies participating the Breast Cancer Association Consortium BRIDGES project. sampled training (80%) validation (20%) sets to analyze rare ATM (1146 variants), BRCA1 (644), BRCA2 (1425), CHEK2 (325), (472). evaluated according five silico prediction-of-deleteriousness algorithms,...
BackgroundGreater degrees of terminal duct lobular unit (TDLU) involution have been linked to lower breast cancer risk; however, factors that influence this process are poorly characterized.
Abstract Introduction: Overall survival of early-stage breast cancer patients is similar for those who undergo breast-conserving therapy (BCT) and mastectomy; however, 10% to 15% women undergoing BCT suffer ipsilateral tumor recurrence. The risk recurrence may vary with subtype. Understanding the gene expression cancer-adjacent tissue stromal response specific subtypes important developing clinical strategies reduce risk. Methods: We utilized two independent datasets study data in from...
Purpose.: To determine the prevalence and associations of myopia in schoolchildren provincial Western China. Methods.: In school-based observational cross-sectional Gobi Desert Children Eye Study, cylcoplegic refractometry as part a comprehensive ophthalmic examination was performed all schools oasis region Ejina. Out 1911 eligible children, 1565 (81.9%) children with mean age 11.9 ± 3.5 years (range, 6–21 years) participated. Results.: The refractive error worse eye −1.38 2.04 diopters (D)...
The chromosome 9p21 region has been implicated in the pathogenesis of multiple cancers. We analyzed single nucleotide polymorphisms (SNPs) from eight genome-wide association studies (GWAS) with data deposited dbGaP, including esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), pancreatic cancer, renal (RCC), lung (LC), breast (BrC), bladder (BC) and prostate (PrC). number subjects ranged 2252 (PrC) to 7619 (LC). SNP-level analyses for each were conducted by logistic regression or...
Elevated mammographic density (MD) is an established breast cancer risk factor. Studies examining relationships between MD and factors are limited in China, where less prevalent but dense breasts more than Western countries. This study included 11,478 women (45-69 years; 36% premenopausal) participating ongoing national screening program 11 urban provinces China predicted as having high-risk for cancer. Polytomous logistic regression was performed to assess associations by comparing each...
Abstract Background Heterogeneity of immune gene expression patterns luminal breast cancer (BC), which is clinically heterogeneous and overall considered as low immunogenic, has not been well studied especially in non-European populations. Here, we aimed at characterizing the profile BC an Asian population associating it with patient characteristics tumor genomic features. Methods We performed profiling adjacent normal tissue 92 patients from Hong Kong using RNA-sequencing data used...
Abstract Background Reproductive factors have been shown to be differentially associated with risk of estrogen receptor (ER)-positive and ER-negative breast cancer. However, their associations intrinsic-like subtypes are less clear. Methods Analyses included up 23 353 cases 71 072 controls pooled from 31 population-based case-control or cohort studies in the Breast Cancer Association Consortium across 16 countries on 4 continents. Polytomous logistic regression was used estimate association...
The chromosome 9p21.3 region has been implicated in the pathogenesis of multiple cancers. We systematically examined up to 203 tagging SNPs 22 genes on (19.9–32.8 Mb) eight case–control studies: thyroid cancer, endometrial cancer (EC), renal cell carcinoma, colorectal (CRC), adenoma (CA), oesophageal squamous carcinoma (ESCC), gastric cardia adenocarcinoma and osteosarcoma (OS). used logistic regression perform single SNP analyses for each study separately, adjusting study-specific...
Summary In a previous whole exome sequencing of patients from 41 families with Hodgkin lymphoma, we identified two distinct heterozygous rare coding variants in POT 1 (D224N and Y36H), both highly conserved region the gene. D224N mutant did not bind to single‐stranded telomere oligonucleotide vitro suggesting mutation perturbs 1's ability telomeric G‐rich overhang. Human HT 1080 cells expressing lymphoblastoid carrying Y36H showed increased length fragility comparison wild type cells. This...
Abstract TP53 mutations are common in breast cancer and typically associated with more aggressive tumor characteristics, but little is known about the clinicopathological epidemiological relevance of p53 protein expression, a mutation surrogate, subtypes. In this study 7226 Chinese women invasive cancer, we defined subtypes using immunohistochemical (IHC) measures hormone receptors HER2 conjunction histologic grade. expression status was then used to further stratify into p53-positive...
Evidence linking coding germline variants in breast cancer (BC)-susceptibility genes other than BRCA1, BRCA2, and CHEK2 with contralateral (CBC) risk cancer-specific survival (BCSS) is scarce. The aim of this study was to assess the association protein-truncating (PTVs) rare missense (MSVs) nine known (ATM, BARD1, CHEK2, PALB2, RAD51C, RAD51D, TP53) 25 suspected BC-susceptibility CBC BCSS. Hazard ratios (HRs) 95% confidence intervals (CIs) were estimated Cox regression models. Analyses...
Abstract Improved understanding of the etiology estrogen receptor-α (ERα)–negative and progesterone receptor (PR)–negative breast cancers may permit improved risk prediction. In vitro studies implicate DNA hypermethylation ERα PR promoters in pathogenesis ERα-negative PR-negative tumors, but results are not definitive. We evaluated 200 invasive selected from a population-based case-control study. extracted fixed tumor tissue cores was tested using MethyLight to assess methylation at four CpG...
A major challenge in studies of etiologic heterogeneity breast cancer has been the limited throughput, accuracy, and reproducibility measuring tissue markers. Computerized image analysis systems may help address these concerns, but published reports their use are limited. We assessed agreement between automated pathologist scores a diverse set immunohistochemical assays done on microarrays (TMA).