A5045781381- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Global Cancer Incidence and Screening
- Dental Education, Practice, Research
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Cancer and Skin Lesions
- Medical Education and Admissions
- Breast Implant and Reconstruction
- Global Health Workforce Issues
- Dental Research and COVID-19
- MRI in cancer diagnosis
- Genetic factors in colorectal cancer
- Parathyroid Disorders and Treatments
- Cancer Risks and Factors
- Viral-associated cancers and disorders
- Reconstructive Surgery and Microvascular Techniques
- Genetic Associations and Epidemiology
- Genetic Syndromes and Imprinting
- Nutritional Studies and Diet
- AI in cancer detection
- Cardiac, Anesthesia and Surgical Outcomes
- Salivary Gland Tumors Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Aortic aneurysm repair treatments
Princess Alexandra Hospital
2012-2024
Centre for Human Genetics
2023
University of Oxford
2023
University of Birmingham
2023
The University of Queensland
2003-2022
Translational Research Institute
2021-2022
Griffith University
2022
Royal Brisbane and Women's Hospital
1989-2021
Medical Research Council
2021
Peter MacCallum Cancer Centre
2021
PURPOSE Establishing accurate age-related penetrance figures for the broad range of cancer types that occur in individuals harboring a pathogenic germline variant TP53 gene is essential to determine most effective clinical management strategies. These also permit optimal use cosegregation data classification variants unknown significance. Penetrance estimation can easily be affected by bias from ascertainment criteria, an issue not commonly addressed previous studies. MATERIALS AND METHODS...
Abstract In the discussion of inclusion generic skills in courses, voices employers, universities and government have been clearly heard. However, undergraduate student voice has largely missing. This paper outlines results a survey staff students. Part A asked participants to rate set terms their importance. B add other that they considered important. The demonstrate significant year effects. For example higher‐order such as critical thinking are rated more important at third than first...
Several different viruses have been proposed to play a role in breast carcinogenesis. The aim of this study was investigate the prevalence subset cancer tissue. We investigated 12 DNA viruses: EBV and CMV from Herpesviridae family SV40, BKV, JCV, MCV, WUV, KIV, LPV, HPyV6, HPyV7, TSV Polyomaviridae 54 fresh frozen tumour specimens. Relevant clinical data basic lifestyle were available for all patients. tissue samples extracted real-time PCR assays used viral detection. highest prevalence,...
Evidence linking coding germline variants in breast cancer (BC)-susceptibility genes other than BRCA1, BRCA2, and CHEK2 with contralateral (CBC) risk cancer-specific survival (BCSS) is scarce. The aim of this study was to assess the association protein-truncating (PTVs) rare missense (MSVs) nine known (ATM, BARD1, CHEK2, PALB2, RAD51C, RAD51D, TP53) 25 suspected BC-susceptibility CBC BCSS. Hazard ratios (HRs) 95% confidence intervals (CIs) were estimated Cox regression models. Analyses...
Abstract While the etiology of breast cancer remains enigmatic, some recent reports have examined role human papillomavirus (HPV) in carcinogenesis. The purpose this study was to determine prevalence HPV tissue using PCR analysis and sequencing. Fifty‐four (54) fresh frozen cancers samples that were removed from a cohort patients analyzed. Samples tested for comprehensive primers, situ hybridization performed on paraffin embedded sections. Findings correlated with clinical pathological...
We have recently demonstrated that BEX2 is differentially expressed in primary breast tumors and expression required for the Nerve Growth factor inhibition of ceramide-induced apoptosis cancer. In this study we investigate functional role survival growth cancer cells. demonstrate downregulation induces mitochondrial sensitizes cells to pro-apoptotic effects ceramide, doxorubicin staurosporine. addition, overexpression protects against apoptosis. show effect mediated through modulation Bcl-2...
Axillary lymph node status is one of the most powerful prognostic factors for patients with breast cancer and often critical in stratifying into adjuvant treatment regimens. In 203 apparently node-negative cases cancer, a combination immunohistochemical staining step-sectioning identified occult metastases 25% cases. Ten-year follow-up information available these patients. Histologic features primary tumor estrogen receptor, progesterone Her-2, p53 were also evaluated. With multivariate...
Abstract Infectious agents are thought to be responsible for approximately 16% of cancers worldwide, however there mixed reports in the literature as prevalence and potential pathogenicity viruses breast cancer. Furthermore, most studies date have focused primarily on viral DNA rather than expression transcripts. We screened a large cohort fresh frozen cancer normal tissue specimens collected from patients Australia presence human papilloma virus (HPV) DNA, with an overall HPV 10% malignant...
Abstract Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development precision oncology treatments based on a tumour’s molecular profile. We aimed to develop targeted gene panel for application disparate cancer types with particular focus tumours head and neck, plus test utility in liquid biopsy. The final designed through Roche/Nimblegen combined 451 cancer-associated genes (2.01 Mb target region). 136 patient DNA samples were collected...
The description of genes and genetic syndromes, such as ataxia-telangiectasia, that predispose some women to breast cancer will provide greater insight into the basis susceptibility. Our goal was establish cell lines from patients with bladder cancers, screen for enhanced levels radiation-induced arrest in G 2 phase cycle is observed ataxia-telangiectasia heterozygotes, correlate other prognostic indicators these cancers vivo radiosensitivity. Epstein-Barr virus-transformed lymphoblastoid...
Columnar cell change with atypia (CCCA) is a relatively recently recognized pathologic breast entity considered to be risk factor for subsequent development of carcinoma. The aim this study was investigate the significance finding CCCA on core biopsy, by establishing frequency other pathology subsequently performed surgical excision specimens. All cases as most advanced lesion biopsy were reviewed. After excision, another proliferative identified in 17 (33%) patients, including three...
Abstract Introduction The purpose of the study is to assess role preoperative magnetic resonance (MR) imaging on surgical management invasive lobular carcinoma (ILC) and evaluate whether breast density background parenchymal enhancement (BPE) influence treatment. Methods This retrospective was conducted 56 patients who were diagnosed with ILC between 2014 2020. All had mammogram ultrasound. Preoperative MRI available in 34 patients. Age, menopausal status, density, BPE,...
Leiomyoma is a rare, benign neoplasm of the nipple. We report case patient with leiomyoma arising from her left nipple who presented persistent pain and tenderness which led to eventual complete excision areola complex. The clinical characteristics, gross microscopic pathologic findings, management this lesion are discussed. Surgical should be tailored primarily control symptoms. Clinicians aware that but potential cause chronic swelling in region nipple-areola complex breast.