A5035690807- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Renal and Vascular Pathologies
- Urological Disorders and Treatments
- MRI in cancer diagnosis
- Urologic and reproductive health conditions
- Clinical practice guidelines implementation
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Meta-analysis and systematic reviews
- Ferroptosis and cancer prognosis
- Multiple and Secondary Primary Cancers
- Cancer, Lipids, and Metabolism
- Pelvic floor disorders treatments
- Pediatric Urology and Nephrology Studies
- Cancer Immunotherapy and Biomarkers
- Hearing Loss and Rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory Biomarkers in Disease Prognosis
- Testicular diseases and treatments
- Abdominal vascular conditions and treatments
- Economic and Financial Impacts of Cancer
Asan Medical Center
2017-2025
Ulsan College
2015-2025
Dongnam Institute of Radiological & Medical Sciences
2021-2025
University of Ulsan
2015-2025
Pusan National University Hospital
2014-2024
Busan Medical Center
2013-2020
Cleveland Clinic
2018-2020
Temple University Hospital
2019
Pusan National University
2015-2019
Palmetto Hematology Oncology
2018
The present study aimed to evaluate the incidence, characteristics and management of hepatic immune‑related adverse events (irAEs) in patients with advanced or metastatic urothelial carcinoma (UC) renal cell (RCC) receiving immune checkpoint inhibitors (ICIs). Data regarding demographics, ICI regimens irAEs from 213 UC RCC ICIs between February 2018 September 2023 at three tertiary medical centers (Inje University Busan Paik Hospital, Busan, South Korea; Dongnam Institute Radiological...
Androgen-receptor splice variant 7 (AR-V7) is associated with castration-resistant prostate cancer (CRPC) and resistance to anti-androgen therapy. Despite its clinical importance, the lack of efficient methods for AR-V7 analysis remains a challenge broader use this biomarker in routine practice. Herein, we suggest practical non-invasive liquid biopsy method RNA urine-derived extracellular vesicles (EVs) without need blood withdrawal. Urine-derived EVs were isolated by lab-on-a-disc...
Anti-programmed death-ligand 1 (PD-L1) Ab-based therapies have demonstrated potential for treating metastatic urothelial cancer with high PD-L1 expression. Urinary exosomes are promising biomarkers liquid biopsy, but urine's variability requires normalization accurate analysis. This study proposes using the PD-L1/Alix ratio to normalize exosomal signal intensity Alix, an internal protein less susceptible heterogeneity concerns than surface markers. Extracellular vesicles were isolated...
Background The Vesical Imaging–Reporting and Data System (VI‐RADS) is a newly developed system of bladder cancer staging with multiparametric MRI (mpMRI), which can be used to predict the presence muscle invasion for cancer. Purpose To evaluate accuracy three mpMRI series (T 2 WI, diffusion‐weighted imaging [DWI], dynamic contrast‐enhanced image [DCEI]) VI‐RADS diagnosing invasive (MIBC). Study Type Retrospective. Population In all, 66 pathologically proven cancers in 32 patients. Field...
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Adjuvant chemotherapy (AC) is recommended for muscle-invasive or lymph node-positive upper urinary tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). However, disease recurrences are frequently observed in pT1 disease, and AC may increase the risk of overtreatment pT2 UTUC patients. This study aimed to validate a risk-adapted scoring model selecting patients with ≤pT2 who would benefit from AC. We retrospectively analyzed 443 underwent RNU. A was applied, categorizing...
Prostate cancer (PCa) diagnosis faces significant challenges due to its complex pathological characteristics and insufficient pathologist resources. While deep learning-based image analysis (DLIA) shows promise in enhancing diagnostic accuracy, application radical prostatectomy (RP) specimens remains underexplored. In this study, we evaluated the clinical feasibility prognostic value of a DLIA algorithm for Gleason grading tumor quantification on whole RP specimens. Using 29,646 digitized...
A 71-year-old man was referred for painless hematuria and a bladder tumor.Cystoscopy computed tomography revealed 3-cm oval nodular mass on the left lateral side of bladder.The patient underwent complete transurethral resection lesion histology showed proliferation atypical spindle cells with inflammation consistent myofibroblastic tumor.After 4 7 months, follow-up cystoscopy demonstrated lesions tumor done, which chronic cystitis recurred tumor, respectively.Five months later, multiple...
Despite the large number of analytical reports regarding learning curve in transition from open to robot-assisted radical prostatectomy (RARP), few comparative results with laparoscopic (LRP) have been reported. Thus, we evaluated operative and postoperative outcomes RARP versus 100 simultaneously performed LRPs. A single surgeon had more than 1,000 operations, including 415 cases nephrectomy, 85 cystectomies, 369 prostatectomies, treatment 212 other urological tumors, since 2009. We...
Purpose: This study evaluated the demographics and semen parameters of males with cancer who banked their sperm prior to chemotherapy. Materials Methods:This is a retrospective 66 cases referred for banking initiation chemotherapy over 15-year period (1999∼2014).Patients had previously received treatment including or radiotherapy were not included in this study. Results:We studied total patients cryopreservation chemotherapy.The mean age at time was 32.0±7.9 years (range, 19∼58 years).The...
We evaluated the clinical and therapeutic characteristics of adult cryptorchidism, which have been difficult to establish, given small number patients presenting outpatient clinics.A retrospective study 20 with cryptorchid testis was performed. analyzed their palpation testis, location, surgical method, marital status, children, histologic findings, semen analysis.In 17 cases unilateral mean age at surgery 31.1±12.5 years. Fourteen had a palpable, testis. The location as verified, inguinal...
This study is designed to identify the androgen receptor variant 7 (AR-V7) status, clinical significance of AR-V7 in hormone sensitive prostate cancer (HSPC). Then, we evaluated and changes its target gene, ubiquitin-conjugating enzyme E2C (UBE2C) which an anaphase-promoting complex/cyclosome (APC/C)-specific enzyme, castration-resistant (CRPC) serial tumor biopsies from patients receiving deprivation therapy.We used RT-PCR Q-PCR assay evaluate AR-V7, full length (AR-FL), UBE2C with HSPC...
Aim This study evaluated the prognosis and survival predictors for bladder urachal carcinoma (UC), based on large scale multicenter cohort with long term follow-up database. Methods A total 203 patients UC treated at 19 hospitals were enrolled. Clinical parameters presentation, diagnosis, therapeutic methods reviewed primary cancer all subsequent recurrences. The stage of was stratified by Mayo Sheldon pathological staging system. Oncological outcomes possible clinicopathological associated...
Prostate cancer (PCa), bladder (BCa), and renal cell carcinoma (RCC) are the most prevalent among urological cancers. However, there no cancer-specific symptoms that can differentiate them as well early clinical signs of malignancy. Furthermore, many metabolic studies have been conducted to discover their biomarkers, but profiling study discriminate between these cancers not yet described. Therefore, in this study, we aimed investigate urinary differences male patients with PCa (n = 24), BCa...
Our objective was to evaluate the use of a holmium laser for transurethral deroofing prostatic abscess in patients with severe and multiloculated abscesses. From January 2011 April 2014, eight who were diagnosed abscesses underwent at Pusan National University Hospital retrospectively reviewed. Multiloculated or multifocal cavities found on preoperative computed tomography (CT) scan all patients. All had successful outcomes, without need secondary surgery. Of patients, seven enucleation...