A5100726110- Sexual function and dysfunction studies
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Urological Disorders and Treatments
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Pelvic floor disorders treatments
- Cancer Immunotherapy and Biomarkers
- Urinary Tract Infections Management
- Pediatric Urology and Nephrology Studies
- Cancer Genomics and Diagnostics
- Silk-based biomaterials and applications
- Urinary and Genital Oncology Studies
- Kidney Stones and Urolithiasis Treatments
- Sexual Differentiation and Disorders
- Electrospun Nanofibers in Biomedical Applications
- Genital Health and Disease
- Genetics, Bioinformatics, and Biomedical Research
- Cancer Mechanisms and Therapy
- Urologic and reproductive health conditions
- Tuberous Sclerosis Complex Research
- Fish Ecology and Management Studies
- Immune cells in cancer
- Cervical Cancer and HPV Research
Korea University
2015-2025
Korea University Medical Center
2013-2024
Duke University Hospital
2023
Duke Medical Center
2023
Inje University Ilsan Paik Hospital
2016-2023
Seoul National University
2007-2018
Nashville Oncology Associates
2018
Seoul Medical Center
2018
Yang Hospital
2017-2018
Broad Institute
2017
The hallmark of human cancer is heterogeneity, reflecting the complexity and variability vast array somatic mutations acquired during oncogenesis. An ability to dissect this identify subgroups that represent common mechanisms disease, will be critical understanding complexities genetic alterations provide a framework develop rational therapeutic strategies. Here, we describe classification scheme for breast making use patterns pathway activity build on previous subtype characterizations...
African-American men have the highest incidence of and mortality from prostate cancer. Whether a biological basis exists for this disparity remains unclear. Exome sequencing (
Abstract Practical application to three‐dimensional (3‐D) tissue culture has been limited by the structural restriction of two‐dimensional (2‐D) nature electrospun nanofiber mat. In this study, for constructing 3‐D nanofibrous structure as real engineering scaffold, we developed new fabrication process with silk fibroin (SF) electrospinning and evaluated features SF scaffold (SFNS) through morphological cell‐culture analyses. Foam type SFNS exhibited high porosity well large pores its cell...
The Department of Defense has pursued the integration virtual reality simulation into medical training and applications to fulfill need train 100,000 military health care personnel annually. Medical transitions, both when entering an operational area returning civilian theater, are characterized by rapidly reacquire skills that essential but have decayed through disuse or infrequent use. Improved efficiency in reacquiring such is critical avoid likelihood mistakes may result mortality...
Objective:The purposes of this study were to evaluate the expression p16 INK4a (referred as p16) and Ki-67 in cervical intraepithelial neoplasia (CIN), correlation between high-risk human papillomavirus (HPV) infection above biomarkers.Methods: We analyzed 31 patients who diagnosed with CIN at Kwandong University Myongji Hospital from October 2006 September 2007.CIN specimens (CIN1, 12; CIN2, 6; CIN3, 13) obtained by colposcopydirected biopsy (CDB) or loop electrical excision procedure...
Abstract In this study we investigated the blend electrospinning of poly(ϵ‐caprolactone) (PCL) and silk fibroin (SF) to improve biodegradability biocompatibility PCL‐based nanofibrous scaffolds. Optimal conditions fabricate PCL/SF (50/50) nanofiber were established for using formic acid as a cosolvent three‐dimensional (3D) scaffolds prepared by modified process methanol coagulation bath. The physical properties 2D mats 3D highly porous measured compared. To evaluate cytocompatibility...
The Myc pathway, often deregulated in cancer, is critical determining cell fate by coordinating a gene expression program that links the control of proliferation with decisions. As such, precise pathway activity must be achieved to ensure faithful execution appropriate cellular response and prevent progressing toward malignant state. With recent highlighted roles microRNAs (miRNA) as components control, we sought evaluate extent which miRNAs may contribute function. Combined analysis mRNA...
Abstract Controlled biodegradability of biomaterials is very important because different functionality and durability are required for various purposes specific tissues organs. From this point view, silk‐based have poor usability uncontrollable degradability, even though silk fibroin (SF) highly biocompatible a number studies on been published to date. In study, we prepared SF nanofiber mats that were recrystallized in ways. These fabricated by electrospinning with ethanol/propanol mixtures...
Kaposi's sarcoma-associated herpesvirus (KSHV) or human 8 has been established as the etiological agent of sarcoma and certain AIDS-associated lymphomas. KSHV establishes latent infection in these tumors, invariably expressing high levels viral latency-associated nuclear antigen (LANA) protein. LANA is necessary sufficient to maintain episome. It also modulates cellular transcription implicated directly oncogenesis because its ability bind p53 pRb tumor suppressor proteins. Previously, we...
The present study was done to define the degree of intravesical prostatic protrusion (IPP) causing bladder outlet obstruction (BOO) in patients with benign hyperplasia (BPH)/lower urinary tract symptoms.We retrospectively evaluated 239 BPH, analyzing age, IPP, prostate volume, International Prostate Symptom Score (IPSS), and results from a pressure-flow study. Urethral resistance quantified by using BOO index (BOOI), according formula BOOI=PdetQmax-2×Qmax (where Pdet is detrusor pressure at...
Background: This study investigated the clinical features, underlying causes, and management of patients with spontaneous perirenal hemorrhage (Wunderlich syndrome; WS). Methods: We retrospectively reviewed records hospitalized for WS at a single tertiary center between 2011 2024. All were evaluated non-traumatic identified on computed tomography (CT) in emergency department. Clinical variables, including age, diseases, symptoms, hemodynamic instability, hospitalization course, analyzed....
This study was designed to evaluate the efficacy of medical treatment Peyronie's disease.A total 109 patients with disease who had been treated from January 2011 December 2014 were retrospectively reviewed in this study. Forty-four (Group 1) 12 mg potassium para-aminobenzoate daily. Sixty-five 2) combination therapy: tamoxifen (20 mg) and acetyl-L-carnitine (300 twice daily addition a phosphodiesterase type 5 inhibitor. Ability perform sexual intercourse, pain during erection, size plaque,...