A5100424367- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Venous Thromboembolism Diagnosis and Management
- Cancer Genomics and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Global Cancer Incidence and Screening
- Atrial Fibrillation Management and Outcomes
- Topic Modeling
- COVID-19 diagnosis using AI
- Thyroid Cancer Diagnosis and Treatment
- Multimodal Machine Learning Applications
- Colorectal Cancer Screening and Detection
- Acute Myocardial Infarction Research
- Immunotherapy and Immune Responses
- Coronary Interventions and Diagnostics
- Genetic factors in colorectal cancer
- Glycosylation and Glycoproteins Research
- Thyroid and Parathyroid Surgery
- Lipoproteins and Cardiovascular Health
- Head and Neck Anomalies
- RNA modifications and cancer
- Domain Adaptation and Few-Shot Learning
- MRI in cancer diagnosis
Wuhan University of Science and Technology
2025
KTH Royal Institute of Technology
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
National Clinical Research
2020-2024
Peking Union Medical College Hospital
2012-2023
Peking University
2023
Xi'an University of Finance and Economics
2006
Hubei University of Science and Technology
2006
In triple-negative breast cancer (TNBC), the benefit of combining chemotherapy with checkpoint inhibitors is still not very clear. We utilize single-cell RNA- and ATAC-sequencing to examine immune cell dynamics in 22 patients advanced TNBC treated paclitaxel or its combination anti-PD-L1 atezolizumab. demonstrate that high levels baseline CXCL13+ T cells are linked proinflammatory features macrophages can predict effective responses therapy. responsive patients, lymphoid tissue inducer (LTi)...
In recent years, deep learning has been widely used in breast cancer diagnosis, and many high-performance models have emerged. However, most of the existing are mainly based on static ultrasound (US) images. actual diagnostic process, contrast-enhanced (CEUS) is a commonly technique by radiologists. Compared with US images, CEUS videos can provide more detailed blood supply information tumors, therefore help radiologists make accurate diagnosis. this paper, we propose novel diagnosis model...
Elevated mammographic density (MD) is an established breast cancer risk factor. Studies examining relationships between MD and factors are limited in China, where less prevalent but dense breasts more than Western countries. This study included 11,478 women (45-69 years; 36% premenopausal) participating ongoing national screening program 11 urban provinces China predicted as having high-risk for cancer. Polytomous logistic regression was performed to assess associations by comparing each...
Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cell derived from menstrual blood, have been recently evaluated as an attractive candidate source in ulcerative colitis (UC); however, the mechanism is not fully understood. The present study was designed to investigate effects ERCs, especially on B-cell responses UC. In this study, induced by administering 3% dextran sodium sulfate (DSS) via free drinking water for 7 days BALB/c mice. treated group, mice were...
Abstract T cell engagers (TCEs) have recent approvals and great potential in the treatment of various diseases such as cancer auto-immune diseases. The challenge TCE solid tumor is therapeutic window due to limited specific targets, CD3 arm requires fine tuning for targets indications. anti-CD3 used current TCEs are monoclonal based diversity epitope potency, which narrows full TCEs. VHHs being single domain, ideal bi- multi-specific molecule design engineering. We identified with diverse...
Endometrial regenerative cells (ERCs) have been recently evaluated as an attractive novel type of stem cell therapy. Previous studies demonstrated that most ERCs accumulated in the lung after injection and are successfully used to treat diseases such cardiac fibrosis. However, relevant idiopathic pulmonary fibrosis (IPF) not reported. The present study was designed examine effects on bleomycin-induced All IPF models C57BL/6 mice were induced by administrating 5 mg/kg bleomycin PBS...
We have previously reported that rhomboid domain containing 1 (RHBDD1), a mammalian protease highly expressed in the testis, can cleave Bcl-2 protein Bik. In this study, we identified multi-pass transmembrane protein, tumor suppressor activated pathway-6 (TSAP6) as potential substrate of RHBDD1. RHBDD1 was found to induce proteolysis TSAP6 dose- and activity-dependent manner. The cleavage not restricted its glycosylated form occurred three different regions. addition, mass spectrometry...
Computationally identifying effective biomarkers for cancers from gene expression profiles is an important and challenging task. The challenge lies in the complicated pathogenesis of that often involve dysfunction many genes regulatory interactions. Thus, sophisticated classification model pressing need. In this study, we proposed efficient approach, called ellipsoidFN (ellipsoid Feature Net), to disease complexity by ellipsoids seek a set heterogeneous biomarkers. Our approach achieves...
The primary aim of this study was to investigate the relationship between contrast-enhanced ultrasonography (CEUS) imaging parameters and clinicopathological features rectal carcinoma assess their potential as new radiological prognostic predictors. A total 66 patients were analyzed with time-intensity curve CEUS. parameter arrival time (AT), peak enhancement (TTP), wash-in (WIT), enhanced intensity (EI), ascending slope (AS) measured. Microvessel density (MVD) evaluated by...
Background: Ultrasound is an important modality for breast cancer screening. However, the evidence on effectiveness of ultrasound screening in population-based program lacking. We aimed to evaluate diagnostic yield a China. Methods: The analyses were conducted context Cancer Screening Program Urban China, which recruited 1,938,996 eligible participants aged 40-69 years from 16 provinces China 2012 2016. included 72,250 women assessed be high-risk who undertook per study protocol. Diagnostic...
IR780 and GOx based PLGA nanospheres can not only selectively accumulate in mitochondria but penetrate into 3D tumors deeply, achieving synergistic treatment of phototherapy GOx-induced starvation therapy under dual-imaging guidance/monitoring.
Background Colorectal cancer (CRC) is an aggressive primary intestinal malignancy with the third-highest incidence and second-highest mortality among all types worldwide. Transcription factors (TFs) regulate cell development differentiation owing to their ability recognize specific DNA sequences upstream of genes. Numerous studies have demonstrated a strong correlation between TFs, etiology tumors, therapeutic approaches. Here, we aimed explore prognosis-related TFs comprehend carcinogenic...
Pediatric community acquired pneumonia (pCAP) is a major public health and economic problem with considerable impact on morbidity mortality in children. Recently many studies meta-analyses have shown promising results the accuracy of lung ultrasonography (LU) diagnosing potentially replacing chest radiography (CR) pediatric population. However, previous establishing LU often used CR as reference standard took into account different clinical settings all together. To make more objective...
Accurate breast lesion segmentation in ultrasound images helps radiologists to make exact diagnoses and treatments, which is important increase the survival rate of cancer patients. Recently, deep learning-based methods have demonstrated remarkable results segmentation. However, blurry boundaries noise artifacts still limit performance methods. In this paper, we propose a novel network equipped with focal self-attention block for improving The can incorporate fine-grained local...
Breast cancer has a high tumor-specific death rate and poor prognosis. In this study, we aimed to provide basis for the prognostic risk in patients with breast using significant gene sets selected by analyzing tumor mutational burden (TMB) DNA damage repair (DDR). genomic transcriptomic data were obtained from The Cancer Genome Atlas (TCGA). samples dichotomized into high- low-TMB groups according TMB values. Differentially expressed DDR genes between incorporated univariate multivariate cox...
e14583 Background: Interleukin (IL)-12 is a potent immunomodulatory cytokine demonstrating robust antitumor activity in multiple preclinical studies and immune-stimulating potential humans. However, systemic delivery of IL-12 can result life-threatening toxicity therefore has shown limited efficacy at doses that be safely administered. ABO2011 human mRNA encapsulated lipid nanoparticle been developed to more effective less toxic through the use novel technology intratumoral injection....