Yan Wu

ORCID: 0009-0008-3348-9232
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About
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Research Areas
  • Ferroptosis and cancer prognosis
  • Cancer Immunotherapy and Biomarkers
  • Prostate Cancer Treatment and Research
  • Health Systems, Economic Evaluations, Quality of Life
  • Cell Adhesion Molecules Research
  • Advanced Breast Cancer Therapies
  • Cancer survivorship and care
  • Lung Cancer Treatments and Mutations
  • Economic and Financial Impacts of Cancer
  • Cancer-related Molecular Pathways
  • COVID-19 and healthcare impacts
  • Cancer Diagnosis and Treatment
  • Esophageal Cancer Research and Treatment
  • RNA modifications and cancer
  • Cancer Cells and Metastasis
  • Chronic Lymphocytic Leukemia Research
  • Cancer-related molecular mechanisms research
  • Cancer-related cognitive impairment studies
  • Helicobacter pylori-related gastroenterology studies
  • Family Support in Illness
  • Peptidase Inhibition and Analysis
  • Ubiquitin and proteasome pathways

Guangzhou University of Chinese Medicine
2025

Second Affiliated Hospital of Harbin Medical University
2021-2024

Harbin Medical University
2021-2024

Pfizer (United States)
2023-2024

Suzhou Research Institute
2024

Rutgers, The State University of New Jersey
2023

Charles R. Drew University of Medicine and Science
2012

Huazhong University of Science and Technology
2007

This study reported the prevalence of financial distress (financial toxicity (FT)) and COVID-19-related economic stress in patients with breast cancer (BC). Patients BC were recruited from Ciitizen platform, Breastcancer.org, patient advocacy groups between 30 March 6 July 2021. FT was assessed COmprehensive Score for Toxicity (COST) instrument. COVID-19 Stress Scale. Among 669 patients, mean age 51.6 years; 9.4% a diagnosis. The rates mild moderate/severe 36.8% 22.4%, respectively. more...

10.3390/cancers16010062 article EN Cancers 2023-12-21

Abstract Background Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) combined with endocrine therapy (ET) are currently recommended by the National Comprehensive Cancer Network (NCCN) guidelines European Society for Medical Oncology (ESMO) as first-line (1 L) treatment patients hormone receptor-positive, human epidermal growth factor receptor 2-negative, locally advanced/metastatic breast cancer (HR+/HER2- LABC/mBC). Although there many options, is no clear standard of care following 1 L...

10.1186/s12885-024-12269-8 article EN cc-by BMC Cancer 2024-05-23

e14583 Background: Interleukin (IL)-12 is a potent immunomodulatory cytokine demonstrating robust antitumor activity in multiple preclinical studies and immune-stimulating potential humans. However, systemic delivery of IL-12 can result life-threatening toxicity therefore has shown limited efficacy at doses that be safely administered. ABO2011 human mRNA encapsulated lipid nanoparticle been developed to more effective less toxic through the use novel technology intratumoral injection....

10.1200/jco.2024.42.16_suppl.e14583 article EN Journal of Clinical Oncology 2024-06-01

Abstract Purpose: To determine the prognostic value of FOXO1, GATA3 and Annexin-1 expression in breast cancer. Methods: Tissue microarray individual paraffin tissue slides from 131 patients were used for study. The association with clinicopathological features cancer disease outcome was examined retrospective samples. Kaplan-Meier survival curves Cox regression multivariate analysis assessing relative risk (RR) disease-free (DFS). determined by immunohistochemistry among three proteins...

10.1158/1538-7445.am2012-704 article EN Cancer Research 2012-04-01

<title>Abstract</title> Background Gastric cancer, a prevalent malignancy, exhibits intricate etiological and pathological characteristics. Recent insights into the dysregulation of clock genes offer novel avenues for diagnosis, treatment, prognosis in patients with gastric cancer. Methods: This study leveraged machine learning, Gene Set Enrichment Analysis (GSEA), immune infiltration analysis, survival drug sensitivity vitro experiments to elucidate role core Results: By integrating TCGA,...

10.21203/rs.3.rs-5397080/v1 preprint EN cc-by Research Square (Research Square) 2024-12-03

Abstract Background Prostate cancer is one of the most lethal cancers in male individuals. The Synaptosome associated protein 25 (SNAP25) gene a key mediator multiple biological functions tumours. However, its significant impact on prognosis prostate remains to be elucidated. Methods We performed comprehensive analysis Cancer Genome Atlas dataset (TCGA) identify differentially expressed genes between and normal tissue. subjected ontology Kyoto Encyclopedia Genes Genomes functional analysis,...

10.21203/rs.3.rs-956253/v1 preprint EN cc-by Research Square (Research Square) 2021-10-12
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