A5055352921- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Schizophrenia research and treatment
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Neurotransmitter Receptor Influence on Behavior
- Cholinesterase and Neurodegenerative Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurobiology of Language and Bilingualism
- Pancreatic function and diabetes
- Psychosomatic Disorders and Their Treatments
- Metabolism, Diabetes, and Cancer
- Fetal and Pediatric Neurological Disorders
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Music Perception
Kuopio University Hospital
2002-2015
Vanha Vaasa hospital
2013-2015
Niuvanniemi Hospital
2015
In-Q-Tel
2015
University of Eastern Finland
1996-2006
Finland University
2002-2004
Centro San Giovanni di Dio Fatebenefratelli
2000-2004
Istituti di Ricovero e Cura a Carattere Scientifico
2004
University of Southern California
2002
North Karelia Central Hospital
2001-2002
To evaluate the impact of midlife elevated serum cholesterol levels and blood pressure on subsequent development mild cognitive impairment (MCI) to investigate prevalence MCI in elderly Finnish population, applying criteria devised by Mayo Clinic Alzheimer's Disease Research Center.MCI has been considered as a predictor AD. Vascular risk factors may be important However, role vascular still remain virtually unknown.Subjects were derived from random, population-based samples previously...
Background: Presence of the apolipoprotein E (apoE) ε4 allele, which is involved in cholesterol metabolism, most important genetic risk factor for Alzheimer disease. Elevated midlife values total level and blood pressure have been implicated recently as factors Objective: To study relative importance putative relationship among apoE level, late-life Design: Prospective population-based study. Setting: Kuopio Joensuu, eastern Finland. Participants: Participants were derived from random...
Hippocampal atrophy detected by volumetric MRI is a sensitive feature of early Alzheimer's disease (AD), but there are no studies evaluating hippocampal MR volumetry in other dementing diseases. We therefore compared volumes total 113 subjects: 50 patients with mild to moderate AD, 9 vascular dementia (VaD), 12 idiopathic Parkinson's (PD) without dementia, 8 PD and (PDD), 34 elderly control subjects. Thin, coronal, contiguous images were obtained 1.5-T imager. All patient groups had...
To test the applicability of an automated method magnetic resonance image analysis (voxel based morphometry) to detect presence and severity regional grey matter density reduction-a proxy atrophy-in Alzheimer's disease.Twenty nine probable patients 26 non-demented controls (mini-mental state examinations mean (SD) 21 (4) 29 (1)) underwent high resolution 3D brain imaging. Spatial normalisation a stereotactic template, segmentation into matter, white cerebrospinal fluid, smoothing were...
To describe atrophic changes of the hippocampus and entorhinal cortex in frontotemporal dementia (FTD) compare them with those AD.The medial temporal lobe shows early course AD, but whether these are specific to AD or occur other degenerative dementias, what extent, is unclear.The authors measured volumes left right from MR images (1.5 T, 2-mm-thick slices) 12 patients FTD, 30 elderly control subjects.In FTD patients, (16% 21% tissue loss) (28% 27% were more than subjects. Atrophy was less...
Verbal fluency tests (VFTs) are suggested to assess frontal lobe function. This view is supported by functional imaging studies that report left activation during VFTs. VFTs require retrieval of semantically associated words from long-term memory storage. The neural networks participate in this process, however, largely unknown. These interest, given patients with early Alzheimer's disease, typically without pathology, often impaired In the present study, magnetic resonance was performed...
<b>Objective:</b> To examine the brain structural correlates of age at onset in patients with Alzheimer’s disease. <b>Methods:</b> We studied nine early (age ⩽65 years), late >65) disease (EOAD and LOAD, respectively) mild-moderate severity, 26 controls who were stratified into younger (YC, ⩽65, n = 9) older (OC, >65, 17) subjects. The closely matched for clinical severity: 3/2/3/1 had dementia rating 0.5/1/2/3, respectively, both groups. High resolution magnetic resonance images EOAD...
Abstract Post mortem studies have revealed a loss of dopamine D2 receptors in the temporal lobes Alzheimer's disease (AD). Moreover, role hippocampal on memory performance has been suggested experimental studies. However, there are no previous vivo extrastriatal AD. Our aim was to examine whether or cortical affected AD and receptor availability is associated with dysfunction seen Fourteen patients probable 11 age‐ sex‐matched controls were studied positron emission tomography using D2/D3...
<b><i>Objective:</i></b> To test the hypothesis that ε4 allele of <i>APOE</i> is associated with a region-specific pattern brain atrophy in AD. <b><i>Methods:</i></b> Volumes hippocampi, entorhinal cortices, and anterior temporal frontal lobes were measured 28 mild to moderate AD patients 30 controls using MRI. Within group, 14 noncarriers (−/−), 9 heterozygous (ε4/−), 5 homozygous (ε4/4) for allele. Dementia severity was similar across three groups. <b><i>Results:</i></b> Smaller volumes...
Abstract Purpose To compare the accuracy of voxel‐based morphometry (VBM) and region interest (ROI)‐based hippocampal volumetry to detect medial temporal lobe atrophy in Alzheimer's disease (AD). Materials Methods A total 27 AD patients (age 74 ± 9 years; 22 women; Mini‐Mental State Exam [MMSE] 21 4) 25 controls 70 8; 16 MMSE 29 1) were studied. Accuracy VBM gray matter loss those seven 11 with similar ROI‐based measures four five VBM‐based was assessed. performed statistical parametric...