Lothar Häberle
A5038957171- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Neutropenia and Cancer Infections
- Estrogen and related hormone effects
- Cancer Risks and Factors
- Cancer Cells and Metastasis
- Digital Radiography and Breast Imaging
- Endometriosis Research and Treatment
- Fungal Infections and Studies
- AI in cancer detection
- Breast Lesions and Carcinomas
- Endometrial and Cervical Cancer Treatments
- Global Cancer Incidence and Screening
- Monoclonal and Polyclonal Antibodies Research
- Ovarian cancer diagnosis and treatment
- Blood disorders and treatments
- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- Uterine Myomas and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Cancer Immunotherapy and Biomarkers
Comprehensive Cancer Center Erlangen
2016-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Universitätsklinikum Erlangen
2016-2025
Düsseldorf University Hospital
2017-2024
Heinrich Heine University Düsseldorf
2017-2024
Heidelberg University
2009-2019
Ludwig-Maximilians-Universität München
2017-2019
University Hospital Heidelberg
2017-2019
University Hospital Ulm
2019
Luisenkrankenhaus
2019
Objectives To determine the long‐term effects of three strength and balance exercise interventions on physical performance, fall‐related psychological outcomes, falls in older people. Design A single‐blinded, four‐group, randomized controlled trial. Setting Community, Germany. Participants Community‐dwelling adults aged 70 to 90 who had fallen past 6 months or reported fear falling. Intervention After baseline assessment, 280 participants were randomly assigned control group ( CG ; no...
Various common genetic susceptibility loci have been identified for breast cancer; however, it is unclear how they combine with lifestyle/environmental risk factors to influence risk. We undertook an international collaborative study assess gene-environment interaction of cancer. Data from 24 studies the Breast Cancer Association Consortium were pooled. Using up 34,793 invasive cancers and 41,099 controls, we examined whether relative risks associated 23 single nucleotide polymorphisms...
Increasing effort has been put in the implementation and certification of breast centers order to establish standardized, quality assured health care for cancer patients. The aim this analysis was investigate whether patients treated certified (CBC) have a favorable prognosis as compared outside treatment units.The data 3,940 with invasive nonmetastatic were analyzed regard differences patient tumor characteristics crude overall survival according diagnosis or CBC Middle Franconia, Germany....
Progress has been made in the treatment of metastatic breast cancer recent decades, but very few therapies use patient or tumor-specific characteristics to tailor individualized treatment. More than ten years after publication reference human genome sequence, analysis methods have improved enormously, fostering hope that biomarkers can be used individualize and offer precise based on tumor characteristics. Biomarkers at every level system (genetics, epigenetics, gene expression, micro-RNA,...
Among patients with metastatic breast cancer (mBC), the frequency of germline mutations in susceptibility genes and clinical relevance these are unclear. In this study, a prospective cohort mBC was used to determine mutation rates for (BC) predisposition genes, evaluate characteristics mutations, assess influence on patient outcome.
Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or time, genotype, may be causally overall, pre/post-menopause, case-groups defined tumour characteristics.
Pembrolizumab is approved for the neoadjuvant/adjuvant treatment of early triple-negative breast cancer (TNBC) patients in combination with chemotherapy. The Keynote-522 trial used platinum As neoadjuvant nab-paclitaxel (nP) also highly effective patients, this study investigates response to nP-containing chemotherapy pembrolizumab.NeoImmunoboost (AGO-B-041/NCT03289819) a multicenter, prospective single-arm phase II trial. Patients were treated 12 weekly cycles nP followed by four...
It has been reported that pathological complete response is an important surrogate marker for disease-free survival and overall in patients with triple-negative breast cancer. This study investigates predictors of the to neoadjuvant platinum-based or anthracycline-based treatment, prognosis, cancer.A total 121 cancer received treatment either platinum anthracycline between 2008 2013. Pathological was assessed relative different treatments using logistic regression models age, clinical tumor...
PurposeTreatment with CDK4/6 inhibitors and endocrine therapy (CDK4/6i + ET) is a standard for patients advanced hormone receptor–positive, HER2-negative (HR HER2–) breast cancer (BC). However, real-world data on the implementation of usage, efficacy, toxicity have not yet been reported.MethodsThe PRAEGNANT registry was used to identify HR HER2– BC (n = 1136). The use chemotherapy, ET, everolimus CDK4/6i ET analyzed first-line, second-line, third-line therapy. Progression-free survival (PFS)...
Abstract Background Anthracycline/cyclophosphamide-taxane-containing chemotherapy (AC-T) is the standard of care in adjuvant treatment HER2-negative early breast cancer (EBC), but recent studies suggest omission anthracyclines for reduced toxicity without compromising efficacy. Methods Based on individual patient data ( n = 5924) pooled from randomised Phase III trials PlanB and SUCCESS C, we compared disease-free survival (DFS) overall (OS) between intermediate to high-risk EBC-patients...
The role of germline genetics in adjuvant aromatase inhibitor (AI) treatment efficacy ER-positive breast cancer is poorly understood. We employed a two-stage candidate gene approach to examine associations between survival endpoints and common variants 753 endocrine resistance-related genes. For discovery cohort, we screened the Breast Cancer Association Consortium database (n ≥ 90,000 cases) retrieved 2789 AI-treated patients. Cox model-based analysis revealed 125 associated with overall,...
The aim of this study was to evaluate the association between thyroid function, reflected by thyroid-stimulating hormone (TSH) levels, and insulin resistance (IR) in 337 women suffering from polycystic ovary syndrome (PCOS). Clinical, metabolic endocrine parameters were obtained an oral glucose tolerance test performed, with calculation IR indices. function evaluated classification analysis using logistic regression 10-fold cross-validation identify a possible TSH threshold for IR....
Although mammographic density is an established risk factor for breast cancer, its use limited in clinical practice because of a lack automated and standardized measurement methods. The aims this study were to evaluate variety texture features mammograms as factors cancer compare them with the percentage (PMD) by using case-control design. A including 864 cases 418 controls was analyzed automatically. Four hundred seventy explored possible cancer. These included statistical features,...
The information available about breast cancer risk factors has increased dramatically during the last 10 years. In particular, studies of low-penetrance genes and mammographic density have improved our understanding risk. addition, initial steps been taken in investigating interactions between environmental factors. This review concerns with actual data on this topic. Several genome-wide association (GWASs) a case–control design, as well large-scale validation studies, identified validated...