A5004436960- Estrogen and related hormone effects
- Cancer Risks and Factors
- Ovarian function and disorders
- Phytoestrogen effects and research
- Reproductive Biology and Fertility
- Dementia and Cognitive Impairment Research
- Gene expression and cancer classification
- Folate and B Vitamins Research
- BRCA gene mutations in cancer
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- Health, Environment, Cognitive Aging
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Nutritional Studies and Diet
- Genetic Associations and Epidemiology
- Ovarian cancer diagnosis and treatment
- Cancer, Stress, Anesthesia, and Immune Response
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Inflammatory mediators and NSAID effects
- HER2/EGFR in Cancer Research
Roche Pharma AG (Germany)
2017-2024
Florey Institute of Neuroscience and Mental Health
2020
The University of Melbourne
2020
Austin Health
2020
Peninsula Health
2020
Eastern Health
2020
Monash Health
2020
Monash University
2020
University of Glasgow
2020
Australian Catholic University
2020
Abstract Introduction We studied whether fully automated Elecsys cerebrospinal fluid (CSF) immunoassay results were concordant with positron emission tomography (PET) and predicted clinical progression, even cutoffs established in an independent cohort. Methods Cutoffs for amyloid‐β 1–42 (Aβ), total tau/Aβ(1–42), phosphorylated tau/Aβ(1–42) defined against [ 18 F]flutemetamol PET Swedish BioFINDER (n = 277) validated F]florbetapir Alzheimer's Disease Neuroimaging Initiative 646). Clinical...
Abstract We evaluated the performance of CSF biomarkers for predicting risk clinical decline and conversion to dementia in non-demented patients with cognitive symptoms. samples from two multicentre longitudinal studies (ADNI, n = 619; BioFINDER, 431) were analysed. Aβ(1–42), tTau pTau concentrations measured using Elecsys immunoassays, tTau/Aβ(1–42) pTau/Aβ(1–42) ratios calculated. Patients classified as biomarker (BM)-positive or BM-negative at baseline. Ability predict AD/dementia was...
Various common genetic susceptibility loci have been identified for breast cancer; however, it is unclear how they combine with lifestyle/environmental risk factors to influence risk. We undertook an international collaborative study assess gene-environment interaction of cancer. Data from 24 studies the Breast Cancer Association Consortium were pooled. Using up 34,793 invasive cancers and 41,099 controls, we examined whether relative risks associated 23 single nucleotide polymorphisms...
Being overweight or obese increases the risk of postmenopausal breast cancer. A potential reason may be frequently observed positive association BMI with endogenous sex hormones and its negative hormone‐binding globulin (SHBG). The purpose this study was to investigate whether a woman's body fat distribution shows BMI‐independent these cancer‐related biomarkers. Performing cross‐sectional analyses among 1,180 women, we assessed associations surrogates for an abdominal (waist circumference;...
Phytoestrogens are structurally similar to estrogens and may affect breast cancer risk by mimicking estrogenic/antiestrogenic properties. In Western societies, whole grains possibly soy foods rich sources of phytoestrogens. A population-based case-control study in German postmenopausal women was used evaluate the association phytoestrogen-rich dietary lignans with risk. Dietary data were collected from 2,884 cases 5,509 controls using a validated food-frequency questionnaire, which included...
Research on the association between dietary patterns and breast cancer survival is very limited. A prospective follow-up study was conducted in Germany, including 2522 postmenopausal patients diagnosed 2001–2005 with available food frequency questionnaire data. Vital status, causes of death, recurrences were verified through end 2009. Principle component factor analysis used to identify pre-diagnostic patterns. Hazard ratios (HRs) 95% confidence intervals (CIs) calculated Cox proportional...
Lignans--plant-derived compounds with estrogen-dependent and -independent anticarcinogenic properties--have been associated postmenopausal breast cancer risk, but data are limited regarding their effect on survival. Dietary lignans metabolized to enterolignans, which subsequently absorbed become bioavailable.We assessed the prognosis of 1,140 patients age 50 74 years who were diagnosed between 2002 2005. Vital status through end 2009 was ascertained via local population registries, deaths...
Lignans – oestrogenic substances present in various foods are associated with postmenopausal breast cancer risk, but not much is known regarding their effects on survival. In a follow-up study of 2653 patients diagnosed between 2001 and 2005, vital status causes death were verified through end 2009. Hazard ratios (HRs) 95% confidence intervals (CIs) for estimated enterolignans, lignan-rich foods, dietary fibre relation to overall survival (OS) cancer-specific (BCSS) assessed using Cox...
To determine a cutoff for the Elecsys AMH Plus immunoassay (Roche Diagnostics International Ltd, Rotkreuz, Switzerland) to identify polycystic ovarian morphology (PCOM), ovary syndrome (PCOS) criterion.The Protein in Humans ovaRian mOrphology DIagnostic TEsting (APHRODITE) study was retrospective, multicenter, case-control study. The serum antimüllerian hormone (AMH) level measured using immunoassay. antral follicle count determined transvaginal ultrasound. An derived and validated separate...
DNA methylation is an epigenetic mechanism that regulates gene expression and can be modified by one-carbon nutrients. The objective of this study was to investigate the impact folic acid (FA) fortification US food supply on leukocyte global relationship between methylation, red blood cell (RBC) folate, other biomarkers among postmenopausal women enrolled in Women's Health Initiative Observational Study. We selected 408 from highest lowest tertiles RBC folate distribution matching age timing...
Abstract Introduction Neurite orientation dispersion and density imaging (NODDI), a multi‐compartment diffusion‐weighted (DWI) model, may be useful for detecting early cortical microstructural alterations in Alzheimer's disease prior to cognitive impairment. Methods Using neuroimaging (NODDI T1‐weighted magnetic resonance [MRI]) cerebrospinal fluid (CSF) biomarker data (measured using Elecsys® CSF immunoassays) from 219 cognitively unimpaired participants, we tested the main interactive...
Circadian rhythms are daily oscillations of multiple biological processes driven by endogenous clocks. Imbalance these has been associated with cancerogenesis in humans. To further elucidate the role circadian clocks have cellular growth control, tumor suppression and cancer treatment, it is revealing to know how clock genes clock-controlled regulated healthy humans.Therefore comparative microarray analyses were conducted investigating relative mRNA expression throughout a 24-hour period...
The use of non‐steroidal anti‐inflammatory drugs (NSAIDs) is associated with reduced risk colorectal neoplasia. Previous studies have reported that polymorphisms in NSAID‐metabolizing enzymes central to NSAID metabolism including UDP‐glucuronosyltransferases (UGT) and cytochrome P450 (CYP) 2C9 may modify this protective effect. We investigated whether 35 functionally relevant within CYP2C9 UGT genes were cancer or modified the effect NSAIDs on susceptibility, using 1,584 cases 2,516...
Background The late endosomal LAMTOR complex serves as a convergence point for both the RAF/MEK/ERK and PI3K/AKT/mTOR pathways. Interestingly, of these signalling cascades play significant role in aetiology breast cancer. Our aim was to address possible genetic polymorphisms LAMTOR2 LAMTOR3 risk factors Methodology/Results We sequenced exons exon–intron boundaries (p14) (MP1) 50 prospectively collected pairs cancerous tissue blood samples from cancer patients compared their variability....
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women and diagnosed using Rotterdam criteria, including diagnosis polycystic ovarian morphology (PCOM) by transvaginal ultrasound (TVUS). Due to high cost, availability, impact operator equipment on reliability antral follicle count (AFC) TVUS, an unmet need exists for a diagnostic test determine PCOM without TVUS. A strong positive correlation between elevated anti-Müllerian hormone (AMH) levels AFCs has been...
Folate-mediated one-carbon metabolism (FOCM) is a key pathway essential for nucleotide synthesis, DNA methylation, and repair. This critical target 5-fluorouracil (5-FU), which predominantly used colorectal cancer (CRC) treatment. A comprehensive assessment of polymorphisms in FOCM-related genes their association with prognosis has not yet been performed. Within 1,739 CRC cases aged ≥30 years diagnosed from 2003 to 2007 (DACHS study), we investigated 397 single (SNPs) 50 candidates 48...
Abstract Objectives Determine variability of serum anti-Müllerian hormone (AMH) levels during ovulatory menstrual cycles between different women (inter-participant), non-consecutive (inter-cycle) and within a single cycle (intra-cycle) in healthy women. Methods Eligible participants were aged 18–40 years with regular cycles. Serum samples collected every second day two AMH measured triplicate using the Elecsys ® Plus immunoassay (Roche Diagnostics). level was evaluated mixed-effects periodic...