A5051987249- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Traumatic Brain Injury and Neurovascular Disturbances
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Statistical Methods in Clinical Trials
- Cerebral Venous Sinus Thrombosis
- Chemotherapy-related skin toxicity
- Acute Ischemic Stroke Management
- Ovarian function and disorders
- Colorectal and Anal Carcinomas
- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- Transcranial Magnetic Stimulation Studies
- Trigeminal Neuralgia and Treatments
- Colorectal Cancer Surgical Treatments
- Clinical Laboratory Practices and Quality Control
- Statistical Methods and Bayesian Inference
- Medical Imaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
Roche (Switzerland)
2015-2024
CS Diagnostics
2024
Roche Pharma AG (Germany)
2016-2023
Ludwig-Maximilians-Universität München
2009-2021
Zimmer Biomet (Germany)
2010-2021
German Cancer Research Center
2013-2014
Heidelberg University
2013-2014
Deutschen Konsortium für Translationale Krebsforschung
2013-2014
Technical University of Munich
2012
Medical University of Vienna
2012
Aim Mirror movements are a transient phenomenon during childhood, which decrease in intensity with motor development. An increasing inhibitory competence resulting the ability of movement lateralization is thought to be underlying mechanism. We aimed quantify unintended mirror systematically across lifespan and investigate influences age, sex, handedness, task frequency. Method A total 236 participants (127 females, 109 males; 216 right‐handed, 20 left‐handed; age range 3–96y, median 25y...
Purpose. This study investigated the impact of early tumor shrinkage (ETS) on progression-free- (PFS) and overall survival (OS) in patients with metastatic colorectal cancer (mCRC) treated within AIO KRK 0104 trial as first-line therapy. Moreover, correlations ETS clinical characteristics prognostic markers were evaluated. Patients methods. In total, 121 included into this analysis. cetuximab combined either CAPIRI or CAPOX. at six weeks was defined a relative change ≥ 20% sum longest...
Early tumor shrinkage ( ETS ) has been highlighted as a favorable prognostic factor related to progression‐free survival PFS and overall OS in cytotoxic treatment of metastatic colorectal cancer. Data from randomized phase III study comparing infusional 5‐fluorouracil plus irinotecan FUFIRI versus oxaliplatin (m IROX were evaluated. Patient groups analyzed according the relative change maximum diameter between baseline after 7 weeks treatment. The cohort was defined decrease ≥20%....
To evaluate blood-based biomarkers to detect endometriosis and/or adenomyosis across nine European centers (June 2014-April 2018).This prospective, non-interventional study assessed the diagnostic accuracy of 54 biomarker immunoassays in samples from 919 women (aged 18-45 years) with suspicion versus symptomatic controls. Endometriosis was stratified by revised American Society for Reproductive Medicine stage. Symptomatic controls were "pathologic controls" or "pathology-free controls". The...
Optical coherence tomography (OCT) allows real-time, in vivo examination of nonmelanoma skin cancer. An innovative high-definition (HD)-OCT with a horizontal (en-face) and vertical (slice) imaging mode offers additional information the diagnosis actinic keratosis (AK) may potentially replace invasive diagnostic biopsies. To define characteristic morphological features AK by using HD-OCT two modes compared histopathology as gold standard. In total, 20 AKs were examined en-face slice described...
The effects of tetrahydrocannabinol (THC) and endogenous cannabinoids (endocannabinoids, ECs) are both mediated by activation the cannabinoid receptors CB1 CB2. Exogenous these THC could therefore alter EC levels. We tested this hypothesis in healthy volunteers (n = 25) who received a large intravenous dose (0.10 mg/kg). Effects on system were quantified serial measurements plasma ECs after administration. Eleven blood samples drawn during first 5 h administration two more 24 48 h. THC, its...
Aim In children with bilateral spastic cerebral palsy (CP), periventricular leukomalacia (PVL) is commonly identified on magnetic resonance imaging. We characterized this white matter condition by examining callosal microstructure, interhemispheric inhibitory competence (IIC), and mirror movements. Method examined seven (age range 11y 9mo–17y 9mo, median age 15y 10mo, four females, three males) CP/PVL (Gross Motor Function Classification System level I or II, Manual Ability I) 12 age-matched...
This retrospective study investigated the clinical characteristics of patients with metastatic colorectal cancer (mCRC) depending on KRAS status, thereby differentiating exon 2 mutations in codon 12 versus 13. In total, 273 mCRC receiving first-line therapy were analyzed. One hundred treated within FIRE-3 trial (FOLFIRI plus cetuximab or bevacizumab), 147 AIO KRK-0104 (cetuximab CAPIRI CAPOX), and further 26 received outside study. Thirty-eight tumors mutation 13, 140 12, 95 wild type as a...
Purpose To compare venous drainage patterns and associated intracranial hydrodynamics between subjects who experienced mild traumatic brain injury (mTBI) age- gender-matched controls. Methods Thirty adult (15 with mTBI 15 controls) were investigated using a 3T MR scanner. Time since trauma was 0.5 to 29 years (mean 11.4 years). A 2D-time-of-flight MR-venography of the upper neck performed visualize cervical vasculature. Cerebral through primary secondary channels, compliance index pressure...
427 Background: The extent of tumor shrinkage in patients (pts) receiving chemotherapy +/- monoclonal antibodies has prognostic value for PFS and OS. "Deepness response (DpR)" is a new efficacy outcome measure that could explain the impact on long-term survival outcome. If takes place DpR percentage observed at nadir compared to baseline. 0 no change negative if load increases. Longest diameter (LD) based RECIST or calculated volume (ASCO GI 2012 #635) can quantify distinct time points. A...
We investigated the impact of diameter valvuloplasty balloon (VB) used for predilation before transcatheter aortic valve implantation (TAVI) on atrioventricular block formation with consecutive need permanent pacemaker (PP) implantation.TAVI was performed in 269 patients using CoreValve prosthesis (Medtronic) via transfemoral access under local anaesthesia mild analgesic medication. After exclusion 32 previously implanted PP, 237 were included a retrospective analysis VB size subsequent PP...
Objectives: The corpus callosum (CC) represents a key structure for hand motor development and is accessible to investigation by diffusion tensor magnetic resonance imaging (DTI) transcranial stimulation (TMS). To identify quantifiable markers development, we combined DTI with TMS. Materials Methods: We examined groups of 11 healthy preschool-aged children, 10 adolescents, adults both, TMS/ipsilateral silent period (iSP). DTI-values fractional anisotropy (FA) were calculated areas I V the...
The aim of this study was to investigate the relationship between pressure setting ventriculoperitoneal (VP) shunt valve and a magnetic resonance (MR)-based estimate intracranial (ICP) in children with shunt-treated hydrocephalus without clinical signs malfunction.Institutional review board approval obtained before study, all subjects and/or their legal guardians provided written informed consent. In prospective 15 consecutive patients (median age, 8.25 years; range, 2.2-18.4 6 girls 9 boys)...
Mutations in the KRAS gene can be detected about 70–90% of pancreatic cancer (PC) cases. Whether these mutations have a prognostic or predictive value remains elusive. Furthermore, clinical relevance extended RAS (KRAS+NRAS) mutational status is unclear PC. We prospectively defined PC patient population who received erlotinib-free chemotherapy regimens. A statistically significant difference between wild-type and mutated tumours at least 160 patients this would support assumption rather role...
The multifunctional cytokine IL-13 is thought to play a central role in Type 2 inflammation asthma. Serum periostin has been explored as candidate biomarker for evaluating activity the airway. We describe technical performance characteristics of novel, fully automated immunoassay determination serum.Limit blank [LoB], limit detection [LoD] and quantitation [LoQ], linearity, precision reproducibility across sites lots were evaluated according Clinical Laboratory Standards Institute...
We aimed to assess whether migraine is associated with changes in the distribution of venous drainage through primary and secondary pathways by using phase-contrast magnetic resonance imaging (MRI).We examined 26 patients (37.3 ± 13.9 years) recurring headaches age- gender-matched controls no neurologic disease 13.7 on a 3 Tesla MR scanner. A 2D time-of-flight MR-venography upper neck region was performed visualize vasculature. Cine-phase contrast scans high-velocity encoding were employed...
<b><i>Purpose:</i></b> This study investigated the impact of specific mutations in codon 12 Kirsten-ras <i>(KRAS)</i> gene on treatment efficacy patients with metastatic colorectal cancer (mCRC). <b><i>Patients:</i></b> Overall, 119 bearing a <i>KRAS</i> mutation were evaluated. All received cetuximab-based first-line chemotherapy within Central European Cooperative Oncology Group (CECOG), AIO KRK-0104 or KRK-0306...
Abstract Background Thunberg's thermal grill produces a sensation of strong heat upon skin contact with spatially interlaced innocuous warm and cool stimuli. Methods To examine the classes peripheral axons that might contribute to this illusion, effects topical l ‐menthol, an activator TRPM8 , cinnamaldehyde, TRPA1 agonist, on magnitude sensations were examined during stimulation in healthy volunteers. Results Under control conditions, cutaneous (interlaced 20/40 ° C ) evoked heat, for...
Abstract Objectives Determine variability of serum anti-Müllerian hormone (AMH) levels during ovulatory menstrual cycles between different women (inter-participant), non-consecutive (inter-cycle) and within a single cycle (intra-cycle) in healthy women. Methods Eligible participants were aged 18–40 years with regular cycles. Serum samples collected every second day two AMH measured triplicate using the Elecsys ® Plus immunoassay (Roche Diagnostics). level was evaluated mixed-effects periodic...
3630 Background: The extent of tumor shrinkage in patients (pts) receiving chemotherapy with or without monoclonal antibodies is prognostic for PFS and OS. ‘Deepness response (DpR)’ concept aims to relate post-progression survival (PPS). If occurs, DpR the percentage observed at nadir compared baseline. 0 no change negative if load increases. Longest diameter (LD) based on RECIST a calculated volume (ASCO GI 2012 #635) can be used quantify load. A joint model was presented #580, ASCO #3603)...