A5110462045- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Cardiovascular Effects of Exercise
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Viral Infections and Immunology Research
- Transplantation: Methods and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Protease and Inhibitor Mechanisms
- Parathyroid Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- European history and politics
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Coronary Interventions and Diagnostics
- Cardiac and Coronary Surgery Techniques
Ludwig-Maximilians-Universität München
2010-2024
Primary Children's Hospital
2019
Eberspächer (Germany)
2017
LMU Klinikum
2009-2015
Segeberger Kliniken
2015
Klinikum Dortmund
2013
University Hospital Carl Gustav Carus
2013
Heidelberg University
2013
Universität Greifswald
2013
University Hospital Heidelberg
2013
In patients with acute pulmonary embolism, systemic thrombolysis improves right ventricular (RV) dilatation, is associated major bleeding, and withheld in many at risk. This multicenter randomized, controlled trial investigated whether ultrasound-assisted catheter-directed (USAT) superior to anticoagulation alone the reversal of RV dilatation intermediate-risk patients. Fifty-nine (63±14 years) main or lower lobe embolism echocardiographic left dimension (RV/LV) ratio ≥1.0 were randomized...
Objectives Chemerin is a recently discovered adipokine that regulates adipocyte differentiation and modulates chemotaxis activation of dendritic cells macrophages. Given the convergence macrophage function, chemerin may provide an interesting link between obesity, inflammation atherosclerosis in humans. We sought to examine relationship i) markers inflammation, ii) components metabolic syndrome, iii) coronary atherosclerotic plaque burden morphology. Design Serum levels were determined 303...
Objectives— Pericardial fat as a visceral depot may be involved in the pathogenesis of coronary atherosclerosis. To gain evidence for that concept we sought to investigate relation pericardial volumes risk factors, serum adiponectin levels, inflammatory biomarkers, and quantity morphology Methods Results— Using Dual source CT angiography volume atherosclerosis were assessed simultaneously. Plaques classified calcified, mixed, noncalcified, number affected segments served quantitative score....
Purpose To determine the feasibility of computed tomography (CT)-based dynamic myocardial perfusion imaging for detection hemodynamically significant coronary artery stenosis, as defined with fractional flow reserve (FFR). Materials and Methods Institutional review board approval informed patient consent were obtained before enrollment in study. The study was HIPAA compliant. Subjects who suspected having or known to have disease underwent electrocardiographically triggered stress imaging....
<h3>Objectives</h3> To evaluate the diagnostic accuracy (DA) of CT-myocardial perfusion imaging (CT-MPI) and a combined approach with CT angiography (CTA) for detection haemodynamically relevant coronary stenoses in patients both suspected known artery disease. <h3>Design</h3> Prospective, non-randomised, study. <h3>Setting</h3> Academic hospital-based <h3>Patients</h3> 65 (42 men age 70.4±9) typical or atypical chest pain. <h3>Interventions</h3> CTA CT-MPI adenosine stress using fast...
Objective The optimal treatment of patients with acute and severe decompensation aortic stenosis is unclear due to recent advances in transcatheter interventions supportive therapies. Our aim was assess the early outcome emergency valve implantation (eTAVI) versus balloon valvuloplasty (eBAV) followed by TAVI under elective circumstances. Methods Emergency conditions were defined as: cardiogenic shock requirement catecholamine therapy, dyspnoea (NYHA IV), cardiac resuscitation or mechanic...
Myocardial infarction results as a consequence of atherosclerotic plaque rupture, with stability largely depending on the lesion forming extracellular matrix components. Lipid enriched non-calcified lesions are considered more instable and rupture prone than calcified lesions. Matrix metalloproteinases (MMPs) degrading enzymes destabilisating characteristics which have been implicated in atherogenesis. We therefore hypothesised MMP-1 MMP-9 serum levels to be associated determined by...
To assess the feasibility of transcatheter aortic valve implantation (TAVI; Medtronic CoreValve and Edwards SAPIEN XT) under local anaesthesia with only mild analgesic medication fluoroscopic guidance.461 patients underwent TAVI lidocaine. The procedure was performed successfully in 459 cases. All were also treated piritramide, metoclopramide hydrochloride 62 mg dimenhydrinate. Monitoring consisted a six-electrode, virtual 12-lead ECG, pulse oximetry, invasive arterial pressure measurement....
Background Atherosclerosis is the primary cause of coronary artery disease (CAD). There increasing recognition that lesion composition rather than size determines acute complications atherosclerotic disease. Low serum adiponectin levels were reported to be associated with and future incidence syndrome (ACS). The impact on still remains determined. Methodology/Principal Findings We measured in 303 patients stable typical or atypical chest pain, who underwent dual-source multi-slice...
In the current study we assess impact of two different access-site suture-mediated closure devices (SMCD), ProGlide and Prostar, on vascular bleeding complications after transfemoral transcatheter aortic valve implantation (TAVI), as well long-term mortality.From 2008 to 2013, 1,022 patients underwent TAVI in German centres using (n=506) Prostar (n=516) SMCD close access site. The primary outcome was incidence peri-TAVI major according Valve Academic Research Consortium-2 (VARC-2)...
Abstract Background GLP-1 is an incretine hormone which gets secreted from intestinal L-cells in response to nutritional stimuli leading pancreatic insulin secretion and suppression of glucagon release. further inhibits gastric motility reduces appetite conjunction improves postprandial glucose metabolism. Additional vasoprotective effects have been described for experimental models. Despite these actions, associations between endogenous levels cardiovascular disease yet not investigated...
We investigated the impact of diameter valvuloplasty balloon (VB) used for predilation before transcatheter aortic valve implantation (TAVI) on atrioventricular block formation with consecutive need permanent pacemaker (PP) implantation.TAVI was performed in 269 patients using CoreValve prosthesis (Medtronic) via transfemoral access under local anaesthesia mild analgesic medication. After exclusion 32 previously implanted PP, 237 were included a retrospective analysis VB size subsequent PP...
Aims: Our aim was to assess the incidence of aortic regurgitation (AR) after transcatheter valve implantation (TAVI) with second (SXT) versus third-generation (S3) balloon-expandable SAPIEN prosthesis in patients symptomatic stenosis (AS).Methods and results: Of 634 undergoing TAVI our centre from May 2010 July 2014, 354 were treated SXT 100 S3 prosthesis.The primary outcome morethan-mild post-TAVI AR at discharge.Secondary outcomes 30-day all-cause death, any bleeding complications need for...
Conventional cardiac pacemakers are still often regarded as a contraindication to magnetic resonance imaging (MRI). We conducted this study support the hypothesis that it is safe scan patients with in 1.5 Tesla MRI, if close supervision and monitoring well adequate pre- postscan programming provided. followed up 356 (age 61.3 ± 9.1 yrs., 229 men) single (n = 132) or dual chamber 224) urgent indication for cranial MRI 12 months. The scans were performed at 1.5T. During monitored 3-lead ECG...
Hymenoptera venoms contain thrombogenic substances that might be responsible for cardiovascular events independent of anaphylactic reactions.We report a 55-year-old man who experienced an acute ST-elevation myocardial infarction after wasp sting. The patient presented without signs anaphylaxis or shock. coronary angiography showed stent thrombosis the right artery. Percutanous intervention was performed immediately and this is example complication associated with hymenoptera sting, since...
Coronary artery calcifications (CAC) are markers of coronary atherosclerosis, but do not correlate well with stenosis severity. This study intended to evaluate clinical situations where a combined approach calcium scoring (CS) and nuclear stress test (SPECT-MPI) is useful for the detection relevant CAD.Patients indication invasive angiography (ICA) were included into our during 08/2005-09/2008. At first all patients underwent CS procedure as part protocol performed by either using...
Background/Objectives To evaluate the predictive value of CT-derived measurements aortic annulus for prosthesis sizing in transcatheter valve implantation (TAVI) and to calculate optimal cutoff values selection various sizes. Methods The local IRB waived approval this single-center retrospective analysis. Of 441 consecutive TAVI-patients, 90 were excluded (death within 30 days: 13; more than mild regurgitation: 10; other reasons: 67). In remaining 351 patients, CoreValve (Medtronic) Edwards...