A5042362625- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Ion channel regulation and function
- Coronary Artery Anomalies
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Tracheal and airway disorders
- Aortic Disease and Treatment Approaches
- Congenital heart defects research
- Cardiovascular Conditions and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Cardiovascular and Diving-Related Complications
- ECG Monitoring and Analysis
- Vascular anomalies and interventions
- Infective Endocarditis Diagnosis and Management
- Radiation Dose and Imaging
- Renal and Vascular Pathologies
Icahn School of Medicine at Mount Sinai
2020-2023
Mount Sinai Medical Center
2020-2022
Children's Hospital at Montefiore
2011-2020
Montefiore Medical Center
2009-2020
Mount Sinai Hospital
2020
Albert Einstein College of Medicine
2010-2019
Yeshiva University
2014-2018
University of Alabama
2018
Montreal Heart Institute
2016
Children's National
2016
Understanding the basis for differential responses to drug therapies remains a challenge despite advances in genetics and genomics. Induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity investigate pharmacology of disease processes therapeutically genetically relevant primary cell types vitro interweave clinical basic molecular data. We report here derivation iPSCs from long QT syndrome patient with complex genetics. The proband was found have de novo SCN5A LQT-3 mutation...
We report a multiinstitutional study on intermediate-term outcome of intravascular stenting for treatment coarctation the aorta using integrated arch imaging (IAI) techniques.Medical records 578 patients from 17 institutions were reviewed. A total 588 procedures performed between May 1989 and Aug 2005. About 27% (160/588) followed up by further IAI their (MRI/CT/repeat cardiac catheterization) after initial stent procedures. Abnormal studies included: presence dissection or aneurysm...
Sudden cardiac death is a major contributor to mortality for adults with congenital heart disease. The subcutaneous implantable cardioverter-defibrillator (ICD) has emerged as novel tool prevention of sudden death, but clinical performance data disease are limited.A retrospective study involving 7 centers over 5-year period beginning in 2011 was performed. Twenty-one patients (median 33.9 years) were identified. most common diagnosis single ventricle physiology (52%), 9 palliated by Fontan...
Interpretation of pediatric ECGs is limited by lack accurate sex- and race-specific normal reference values obtained with modern technology for all ages. We sought to obtain contemporary digital ECG measurements in healthy children from North America, evaluate the effects sex race, compare our results commonly used published datasets.Digital (12-lead) were retrospectively collected ≤18 years old echocardiograms at 19 centers Pediatric Heart Network. Patients classified into 36 groups: 6 age,...
3‐D Mapping Improves Success Rates for WPW Ablation Introduction Three‐dimensional mapping (3‐D) systems are frequently used ablation of supraventricular tachycardia. Prior studies have demonstrated radiation dosage reduction with 3‐D, but there no data on whether improves the efficacy Wolff‐Parkinson‐White syndrome (WPW). We sought to determine if success rate in children. Methods Multicenter retrospective study including patients ≤21 years age undergoing from 2008 2012. rates using 2...
BackgroundSCN5A encodes the α-subunit (Nav1.5) of principle Na+ channel in human heart. Genetic lesions SCN5A can cause congenital long QT syndrome (LQTS) variant 3 (LQT-3) adults by disrupting inactivation Nav1.5 channel. Pharmacological targeting mutation-altered channels has proven promising developing a gene-specific therapeutic strategy to manage specifically this LQTS variant. mutations that similar dysfunction may also contribute sudden infant death (SIDS) and other arrhythmias...
Background Ablation for supraventricular tachycardia (SVT) relies upon fluoroscopy (fluoro), which exposes the patient and staff to ionizing radiation. The objective of this work was present a new “ALARA—As Low As Reasonably Achievable” protocol with alterations fluoroscopic x‐ray parameters reduce dose without an electroanatomical (EAM) approach. Methods All patients <21 years age undergoing ablation SVT at our institution from June 2011 April 2012 were included. EAM not utilized in any...
Surveillance endomyocardial biopsy (EMB) with right heart catheterization (RHC) is the standard of care for assessment post cardiac transplantation rejection. This procedure has traditionally relied upon fluoroscopy, which exposes both patient and staff to risks ionizing radiation. These may be particular concern in transplant who must undergo many such procedures lifelong. We present data on a new "ALARA - As Low Reasonably Achievable" protocol reduce radiation exposure during performance...
"ALARA--As Low As Reasonably Achievable" protocols reduce patient radiation dose. Addition of electroanatomical mapping may further dose.From 6/11 to 4/12, a novel ALARA protocol was utilised for all patients undergoing supraventricular tachycardia ablation, including low frame rates (2-3 frames/second), fluoro dose/frame (6-18 nGy/frame), and other techniques fluoroscopy (ALARA). From 6/12 3/13, use CARTO® 3 (C3) with "fast anatomical mapping" (ALARA+C3) added the protocol. Intravascular...