A5076767794- Congenital Heart Disease Studies
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Cardiovascular and Diving-Related Complications
- Infective Endocarditis Diagnosis and Management
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Conditions and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Organ Transplantation Techniques and Outcomes
- Viral-associated cancers and disorders
- Congenital heart defects research
- Cardiovascular Issues in Pregnancy
- Polyomavirus and related diseases
- Optical Imaging and Spectroscopy Techniques
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
Heart and Diabetes Center North Rhine-Westphalia
2021-2025
Ruhr University Bochum
2021-2025
German Centre for Cardiovascular Research
2016-2024
Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer
2024
Bayer (Germany)
2015-2024
Deutsches Herzzentrum der Charité
2014-2023
Deutsches Herzzentrum München
2014-2023
Berlin Heart (Germany)
2019
Stanford University
2016
London School of Economics and Political Science
2016
Background— Off-label use of transcatheter aortic and pulmonary valve prostheses for tricuspid valve-in-valve implantation (TVIV) within dysfunctional surgical (TV) bioprostheses has been described in small reports. Methods Results— An international, multicenter registry was developed to collect data on TVIV cases. Patient-related factors, procedural details outcomes, follow-up were analyzed. Valve-in-ring or heterotopic TV procedures not included. Data collected 156 patients with...
Congenital heart defects (CHDs) are the most common birth defect worldwide and a leading cause of neonatal mortality. Nonsyndromic atrioventricular septal (AVSDs) an important subtype CHDs for which genetic architecture is poorly understood. We performed exome sequencing in 13 parent-offspring trios 112 unrelated individuals with nonsyndromic AVSDs identified five rare missense variants (two arose de novo) highly conserved gene NR2F2, very significant enrichment (p = 7.7 × 10−7) compared to...
Purpose To reduce the need for diagnostic catheterization and optimize treatment in a variety of congenital heart diseases, magnetic resonance imaging (MRI)‐based computational fluid dynamics (CFD) is proposed. However, data about accuracy CFD clinical context are still sparse. fill this gap, study compares MRI‐based to coarctation aorta (CoA) setting. Materials Methods Thirteen patients with CoA were investigated by routine MRI prior catheterization. 3D whole‐heart was used reconstruct...
Posttransplantation lymphoproliferative disorders (PTLD) present a major cause of mortality and morbidity after solid organ transplantation. The purpose this study was to identify the factors associated with development early- late-onset PTLD in pediatric transplant recipients.We examined medical history, laboratory parameters, pathology 127 children who were registered German multicenter registry. Data collected retrospectively from 1991 2003 prospectively 2004 onward. We compared early (<1...
Myocarditis is one of the most common causes leading to heart failure in children and a possible genetic background has been postulated. We sought characterize clinical characteristics patients with myocarditis ≤18 years age predict outcome.A cohort 42 (Genetics Pediatric Myocarditis) biopsy-proven underwent testing targeted panel sequencing cardiomyopathy-associated genes. Genetics were divided into subgroups according phenotype dilated cardiomyopathy (DCM) at presentation, resulting 22...
Abstract Transcatheter closure of atrial septal defects (ASDs) is a safe and effective treatment. Over the past years, an increasing number elderly patients (age > 60 years) have been admitted for transcatheter to prevent ongoing congestive heart failure from volume overload. However, recent data point risk serious acute left ventricular dysfunction leading pulmonary edema immediately after surgical or ASD in some patients. In this study, we used technique described before recognize...
Abstract Fontan-palliated patients are at risk for the development of Fontan-associated liver disease (FALD). In this study, we performed a detailed hemodynamic and hepatic assessment to analyze incidence spectrum FALD its association with patients' hemodynamics. From 2017 2019, 145 underwent detailed, age-adjusted examination including laboratory analysis (FibroTest ® , n = 101), ultrasound ( 117) transient elastography (FibroScan 61). The median patient age was 16.0 years [IQR 14.2],...
Background Infective endocarditis (IE) after pulmonary valve replacements in congenital heart disease is a significant concern. This study aimed to identify specific long-term risk factors for IE percutaneous implantation or surgical replacement. Methods and Results All patients with from the National Register Congenital Heart Defects at least 1 replacement before January 2018 were included. A total of 1170 (56.3% men, median age inclusion 12 [interquartile range {Q1-Q3} 5-20 years])...
Abstract Background and Aims Transcatheter pulmonary valve implantation (TPVI) is indicated to treat right-ventricular outflow tract (RVOT) dysfunction related congenital heart disease (CHD). Outcomes of TPVI with the SAPIEN 3 that are insufficiently documented were investigated in EUROPULMS3 registry 3-TPVI. Methods Patient-related, procedural, follow-up outcome data retrospectively assessed this observational cohort from 35 centres 15 countries. Results Data for 840 consecutive patients...
PTLD is a severe complication in transplant recipients. Detection of increased EBV load the peripheral blood acts as surrogate marker for risk development. We analyzed time course disease, its severity, organs involved, and mortality rates our institutional experience pediatric heart transplantation. This paper identifies factors describes different ways diagnosing treating disease. was screened 146 patients using retrospective analysis who received transplantation before 1998. Prospective...