A5073563908- Viral Infections and Immunology Research
- Congenital Heart Disease Studies
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Congenital Diaphragmatic Hernia Studies
- Kawasaki Disease and Coronary Complications
- Cardiovascular Conditions and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiomyopathy and Myosin Studies
- Coronary Artery Anomalies
- Viral gastroenteritis research and epidemiology
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- SARS-CoV-2 and COVID-19 Research
- Intestinal Malrotation and Obstruction Disorders
- Liver Disease Diagnosis and Treatment
- Animal Virus Infections Studies
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Syncope and Autonomic Disorders
- Lymphatic Disorders and Treatments
- Tracheal and airway disorders
- Myasthenia Gravis and Thymoma
- Respiratory viral infections research
Charité - Universitätsmedizin Berlin
2016-2025
Deutsches Herzzentrum der Charité
2023-2025
Freie Universität Berlin
2021-2024
Humboldt-Universität zu Berlin
2021-2024
Deutsches Herzzentrum München
2017-2019
Zentrum für Kinderheilkunde
2007-2010
Hospital for Sick Children
2006
Centre Hospitalier Universitaire Sainte-Justine
2006
KU Leuven
2006
Background. Studies in patients with childhood-onset end-stage renal disease (ESRD) provide a diagnostic window to the evolution of cardiovascular (CVD) this population. Hyperphosphataemia and osteodystrophy are particularly difficult treat paediatric patients, but there is only limited information regarding effect calcium-containing phosphate binders vitamin D preparations on development CVD young.
Background Variants of the desmosomal protein desmoplakin are associated with arrhythmogenic cardiomyopathy, an important cause ventricular arrhythmias in children and young adults. Disease penetrance variants is incomplete variant carriers may display noncardiac, dermatologic phenotypes. We describe a novel cardiac phenotype truncating variant, likely causing mechanical instability myocardial desmosomes. Methods Results In 2 brothers recurrent myocarditis triggered by physical exercise,...
Myocarditis is one of the most common causes leading to heart failure in children and a possible genetic background has been postulated. We sought characterize clinical characteristics patients with myocarditis ≤18 years age predict outcome.A cohort 42 (Genetics Pediatric Myocarditis) biopsy-proven underwent testing targeted panel sequencing cardiomyopathy-associated genes. Genetics were divided into subgroups according phenotype dilated cardiomyopathy (DCM) at presentation, resulting 22...
Abstract Myocarditis represents an important cause for acute heart failure. MYKKE, a prospective multicenter registry of pediatric patients with myocarditis, aims to gain knowledge on courses, diagnostics, and therapy myocarditis. The role mechanical circulatory support (MCS) in children severe failure myocarditis is unclear. aim this study was determine characteristics outcome requiring MCS and/or transplantation. MYKKE cohort between September 2013 2016 analyzed. A total 195 were...
Long-QT syndrome (LQTS) causes a prolongation of the QT-interval in ECG leading to life threatening tachyarrhythmia and ventricular fibrillation. One atypical form LQTS, Timothy (TS), is associated with syndactyly, immune deficiency, cognitive neurological abnormalities as well distinct cranio-facial abnormalities.On family both children diagnosed clinical we performed whole exome sequencing comprehensively screen for causative mutations after targeted candidate gene panel target genes...
Background Right ventricular outflow tract (RVOT) stenosis after repair of tetralogy Fallot has been linked with favorable right remodeling but adverse outcomes. The aim our study was to assess the hemodynamic impact and prognostic relevance pressure load in this population. Methods Results A total 296 patients repaired (mean age, 17.8±7.9 years) were included a prospective cardiovascular magnetic resonance multicenter study. Myocardial strain quantified by feature tracking technique at...
Background/Objectives: Risk assessment in pediatric myocarditis is challenging, particularly when left ventricular ejection fraction (LVEF) preserved. This study aimed to evaluate LV myocardial deformation using speckle-tracking echocardiography (STE)-derived longitudinal +strain (LS) and assessed its diagnostic prognostic value children with myocarditis. Methods: Retrospective STE-derived layer-specific LS analysis was performed on echocardiograms from patients within the multicenter,...
Implantable cardioverter defibrillator (ICD) therapy of life-threatening arrhythmias in pediatric patients is feasible; however, recent studies report a high incidence inappropriate shock deliveries.The data all recipients an ICD at the Charité, Department Pediatric Cardiology, between January 2001 and November 2007 were retrospectively analyzed regarding underlying cardiac disorders, arrhythmias, medication, ablation procedures, leads devices, programming, therapies.A total 33 underwent...
Abstract We, herein, report the first use of a Magmaris® magnesium‐based vascular scaffold for native aortic coarctation in 1,980 g infant with multiple malformations. Due to low body weight, complex illness, and clinical instability, it was decided delay surgical correction. After insufficient results had been obtained by balloon angioplasty, implantation chosen bridge patient surgery stabilizing left ventricular function allow sufficient growth. significant early stent restenosis complete...
ABSTRACT Fetal cardiac tumors are a rare finding in prenatal ultrasonography. Most of them rhabdomyoma, which thought to be pathognomonic for tuberous sclerosis complex. We present an infant with prenatally diagnosed rhabdomyoma (CR), who was found suffer from Beckwith‐Wiedemann syndrome (BWS). This congenital overgrowth is characterized by macrosomia, macroglossia, omphalocele, hypoglycemia, and hemihypertrophy. BWS patients have increased risk formation benign malignant tumors, typically...
Device thromboses after patent foramen ovale (PFO) and atrial septal defect (ASD) closure are rare but serious complications. They have been reported in different devices of virtually all manufacturers. Here, we report three cases left device thrombosis with the Gore® Cardioform occluder (GSO) our recent institutional experience. All patients were symptomatic new-onset neurological impairments evidence cerebral thromboembolism. occurred despite antiplatelet therapy two moreover observed...
Since the onset of widespread COVID-19 vaccination, increased incidence vaccine-associated myocarditis (VA-myocarditis) has been noted, particularly in male adolescents.
Abstract Agenesis of the superior vena cava is a rare anomaly that generally asymptomatic in neonate. We report male neonate with bilateral (total) agenesis obstructed thoracic duct and subsequent congenital hydrothorax, anomalies were detected by prenatal ultrasound at 25 weeks' gestation. The cardiac was confirmed postnatal magnetic resonance angiography. chylothorax disappeared conservative therapy. Copyright © 2006 ISUOG. Published John Wiley & Sons, Ltd.
Thrombocytopenia is a risk factor for patent ductus arteriosus. Immature and mature platelets exhibit distinct haemostatic properties; however, whether platelet maturity plays role in postnatal, arteriosus closure unknown.In this observational study, counts of immature (=total count - count) were assessed on days 1, 3, 7 life very low birth weight infants (<1500 g weight). We performed echocardiographic screening haemodynamically significant day 7.Counts did not differ 1 with (n = 24)...
Adults with congenital heart disease and ventricular dysfunction are prone to liver congestion, leading fibrosis or cirrhosis but little is known about the prevalence of in atrial switch patients. Liver impairment may develop due increased systemic venous pressures. This prospective study aimed assess non-invasively hepatic abnormalities adults who underwent Senning Mustard procedures.Hepatic involvement was assessed clinically by laboratory analysis, fibrotic markers, sonography, stiffness...
Cardiovascular magnetic resonance serves as a useful tool in diagnosing myocarditis. Current adult protocols are yet to be validated for children; thus, it remains unclear if the methods used can applied with sufficient image quality children. This study assesses use of cardiovascular children suspected myocarditis.Image data from clinical studies performed enrolled Mykke between June 2014 and April 2019 were collected analysed. The sets was evaluated using four-point scale (4: excellent, 3:...
Background Myocarditis can be associated with severe heart failure and is caused by different inflammatory autoimmune responses. The aim of this study was to describe the immunological response in children myocarditis analyzing anti-beta-adrenergic receptor antibodies (anti-β-AR Abs). Methods Sera who were hospitalized biopsy-proven prospectively collected between April 2017 March 2019. Anti-β1-AR Ab, anti-β2-AR anti-β3-AR Ab quantified a CE-certified ELISA kit. According normal values for...
<i>Background:</i> Chorangiomas are villous capillary tumors of the placenta with high impact on neonatal morbidity and mortality. Cardiac complications have occasionally been reported. <i>Objective:</i> To elucidate clinical features, diagnosis treatment cardiac failure caused by chorangiomas. <i>Method:</i>We report a case newborn, in whom massive chorangiomas were associated severe failure, anemia, thrombocytopenia. <i>Results:</i>...
Reverse Potts shunt is a palliative procedure aimed at decompressing the pressure-overloaded right ventricle in severe pulmonary hypertension (PH). We, herein, report first case of an interventional creation "endogenous" reverse by stenting pre-existing small but patent ductus arteriosus (PDA) 2 months old female infant with severe, supra-systemic PH, associated novel combination compound heterozygous ABCA3 mutation and additional genetic variants surfactant protein B (SFTPB) C (SFTPC). The...