A5016772245- Viral Infections and Immunology Research
- Cardiac Fibrosis and Remodeling
- Anesthesia and Pain Management
- Cardiomyopathy and Myosin Studies
- Advanced Glycation End Products research
- Cardiac, Anesthesia and Surgical Outcomes
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- Airway Management and Intubation Techniques
- Cardiac electrophysiology and arrhythmias
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular Effects of Exercise
- Nausea and vomiting management
- interferon and immune responses
- Peptidase Inhibition and Analysis
- Spine and Intervertebral Disc Pathology
- Immune Cell Function and Interaction
- Pediatric Pain Management Techniques
- Ion channel regulation and function
- Tracheal and airway disorders
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Disorders and Syndromes
- Cardiac Structural Anomalies and Repair
Heidelberg University
2015-2025
German Centre for Cardiovascular Research
2015-2025
University Hospital Heidelberg
2011-2023
Heidelberg University
2009-2020
Boğaziçi University
2017
Tokat Gaziosmanpaşa Üniversitesi
2007-2016
University of Cologne
2006-2011
Manisa Celal Bayar University
2009
Ondokuz Mayıs University
2009
Johns Hopkins University
2000-2008
High-mobility group box-1 (HMGB1) is a nuclear factor released by necrotic cells and activated immune cells. HMGB1 signals via members of the toll-like receptor family for advanced glycation end products (RAGE). Although has been implicated in ischemia/reperfusion (I/R) injury liver lung, its role I/R heart remains unclear.Here, we demonstrate that acts as an early mediator inflammation organ damage heart. levels were already elevated 30 minutes after hypoxia vitro ischemic vivo. Treatment...
Immune checkpoint inhibitors (ICIs) are approved for multiple cancers but can result in ICI-associated myocarditis, an infrequent life-threatening condition. Elevations cardiac biomarkers, specifically troponin-I (cTnI), troponin-T (cTnT), and creatine kinase (CK), used diagnosis. However, the association between temporal elevations of these biomarkers with disease trajectory outcomes has not been established.
Cardiac troponins in blood are the most preferred markers of myocardial damage. The fact that they normally not found circulation provides a high level clinical sensitivity and specificity even when cardiac lesions small. After injury, enter circulation, where can be used for diagnosis acute coronary syndromes. Thus, paramount disease classification risk stratification. However, little is known about long-term effects released on function.In this study we prepared recombinant murine troponin...
Significance Myocardial inflammation leads in many cases to cardiomyopathy and contributes progressive heart failure. The exact pathological mechanism of disease induction progression the setting failure is unknown. High-mobility group box 1 (HMGB1), an evolutionarily abundant highly conserved protein, promotes cardiac inflammation, turn immunity, as a damage-associated molecular pattern. HMGB1 stimulates at least part, through interaction with its principal binding partner RAGE (receptor...
Abstract Polyphosphates are linear polymers and ubiquitous metabolites. Bacterial polyphosphates long chains of hundreds phosphate units. Here, we report that mouse survival peritoneal Escherichia coli sepsis is compromised by long-chain polyphosphates, improves with bacterial polyphosphatekinase deficiency or neutralization using recombinant exopolyphosphatase. Polyphosphate activities chain-length dependent, impair pathogen clearance, antagonize phagocyte recruitment, diminish phagocytosis...
Background — Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses. This is believed to be mediated primarily through the activation of STAT4 and subsequent production interferon (IFN)-γ. Methods Results We examined role IL-12 receptor (IL-12R) signaling in development murine experimental autoimmune myocarditis (EAM) induced cardiac myosin immunization. Both IL-12Rβ1–deficient mice STAT4-deficient were resistant induction myocarditis. Treatment...
Autoimmune myocarditis is a principal cause of heart failure among young adults and often precursor dilated cardiomyopathy. Monocyte chemoattractant protein-1 (MCP-1) macrophage inflammatory protein-1alpha (MIP-1alpha) are potent chemotactic factors for mononuclear cells. The infiltrate observed in myocardial lesions consists >70% To determine their critical role the pathogenesis myocarditis, we inhibited cell activation migration to see if it would affect disease severity prevalence...
Background— Despite the widespread use of cardiac troponins for diagnosis myocyte injury and risk stratification in acute disorders, little is known about long-term effects released on function. Recently, we showed that an autoimmune response to troponin I (cTnI) induces severe inflammation subsequent fibrosis myocardium. This disorder predisposes heart failure death mice. Methods Results— To investigate role cTnI-specific T cells, cells were isolated from splenocytes mice immunized with...
Application of antibodies against cardiac troponin I (cTnI-Ab) can induce dilation and dysfunction the heart in mice. Recently, we demonstrated that immunization with cTnI induces inflammation fibrosis myocardium Others have shown auto-antibodies to are present patients acute coronary syndrome, but little is known about clinical relevance detected cTnI-Ab.First, anti-cTnI anti-cTnT antibody titres were measured sera from 272 dilated- (DCM) 185 ischaemic- (ICM) cardiomyopathy. Secondly, 108...
AimsInducible gene targeting in mice using the Cre/LoxP system has become a valuable tool to analyse roles of specific genes adult heart. However, commonly used Myh6-MerCreMer requires time-consuming breeding schedules and is potentially associated with cardiac side effects, which may result transient dysfunction. The aim our study was establish rapid simple for inactivation conditional knockout by transfer Cre recombinase adeno-associated viral vectors serotype 9 (AAV9).
The Quality of Recovery-40 questionnaire (QoR-40) is a self-rated used to assess the postoperative recovery quality and health status patients in early stages following surgery; however, there no Turkish version QoR-40. aim this study was reliability, validity, responsiveness QoR-40 (QoR-40 T). After approval ethics committee, total 137 completed during preoperative period, on third day, one month after surgery. life evaluated by using health-related (Short-Form Health Survey-36; SF-36) day...
Background: Immune checkpoint inhibitor (ICI) therapy is often accompanied by immune-related pathology, with an increasing occurrence of high-risk ICI-related myocarditis. Understanding the mechanisms involved in this side effect could enable development management strategies. In mouse models, immune checkpoints, such as PD-1 (programmed cell death protein 1), control threshold self-antigen responses directed against cardiac TnI (troponin I). We aimed to identify how immunoproteasome, main...
Abstract Aims Heart transplantation may represent a particular risk factor for severe coronavirus infectious disease 2019 (COVID-19) due to chronic immunosuppression and frequent comorbidities. We conducted nation-wide survey of all heart transplant centers in Germany presenting the clinical characteristics recipients with COVID-19 during first months pandemic Germany. Methods results A multicenter evaluating current status among adult was performed. total 21 patients reported Mean patient...
Background Variants of the desmosomal protein desmoplakin are associated with arrhythmogenic cardiomyopathy, an important cause ventricular arrhythmias in children and young adults. Disease penetrance variants is incomplete variant carriers may display noncardiac, dermatologic phenotypes. We describe a novel cardiac phenotype truncating variant, likely causing mechanical instability myocardial desmosomes. Methods Results In 2 brothers recurrent myocarditis triggered by physical exercise,...
Abstract. Andrassy M, Volz HC, Riedle N, Gitsioudis G, Seidel C, Laohachewin D, Zankl AR, Kaya Z, Bierhaus A, Giannitsis E, Katus HA, Korosoglou G (University of Heidelberg, Germany). HMGB1 as a predictor infarct transmurality and functional recovery in patients with myocardial infarction. J Intern Med 2011; 270: 245–253. Objectives. High-mobility group box 1 (HMGB1) protein is an innate danger signal for the initiation host defence tissue repair. The aim this study was to analyse serum...