A5023629110- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Viral Infections and Immunology Research
- Heart Failure Treatment and Management
- GDF15 and Related Biomarkers
- Cell Adhesion Molecules Research
- Mechanical Circulatory Support Devices
- Atherosclerosis and Cardiovascular Diseases
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- Heart Rate Variability and Autonomic Control
- High Altitude and Hypoxia
- Cardiovascular Function and Risk Factors
- IL-33, ST2, and ILC Pathways
- Diet and metabolism studies
- Transplantation: Methods and Outcomes
- Cardiac electrophysiology and arrhythmias
- Galectins and Cancer Biology
- Cardiomyopathy and Myosin Studies
- T-cell and B-cell Immunology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Regulation of Appetite and Obesity
- Immune Cell Function and Interaction
- Macrophage Migration Inhibitory Factor
University Hospital Münster
2008-2024
Bashkir State Medical University
2023
Friedrich Schiller University Jena
2015-2019
University of Münster
2008-2019
Jena University Hospital
2011-2018
Schiller International University
2015
German Society of Medical Intensive Care and Emergency Medicine
2010
Abstract Background Novel biomarkers representing different pathobiological pathways and their role in patients with acute myocardial infarction ( AMI ) were studied. Methods We retrospectively analysed serum levels of soluble suppression tumorigenicity sST 2), growth‐differentiation factor‐15 GDF ‐15), urokinase plasminogen activator receptor (su PAR ), heart‐type fatty acid‐binding protein (H‐ FABP plasma fetuin A blood STEMI , n = 61; NSTEMI 57) compared to controls excluded coronary...
Abstract Aims Heart transplantation may represent a particular risk factor for severe coronavirus infectious disease 2019 (COVID-19) due to chronic immunosuppression and frequent comorbidities. We conducted nation-wide survey of all heart transplant centers in Germany presenting the clinical characteristics recipients with COVID-19 during first months pandemic Germany. Methods results A multicenter evaluating current status among adult was performed. total 21 patients reported Mean patient...
Atherosclerosis is a chronic inflammatory disease of the arterial wall in which presentation autoantigens by dendritic cells (DCs) leads to activation T cells. Anti-inflammatory like Tregs counterbalance inflammation atherogenesis. In our study, human carotid plaque specimens were classified as stable (14) and unstable (15) according established morphological criteria. Vessel (n = 12) without any signs atherosclerosis used controls. Immunohistochemical staining was performed detect different...
Abstract Aims COVID‐19, a respiratory viral disease causing severe pneumonia, also affects the heart and other organs. Whether its cardiac involvement is specific feature consisting of myocarditis, or simply due to microvascular injury systemic inflammation, yet unclear presently debated. Because myocardial common in kinds pneumonias, we investigated compared such occurrence pneumonias COVID‐19 causes. Methods results We analysed data from 156 critically ill patients requiring mechanical...
Background: The long‐QT syndromes (LQTS) are inherited electrical cardiomyopathies characterized by prolonged ventricular repolarization and arrhythmias. Several genetic reports have associated defects in LQTS‐causing genes with atrial fibrillation (AF). We therefore studied whether arrhythmias occur patients LQTS under daily‐life conditions. Methods: systematically assessed matched controls using implanted defibrillators or pacemakers as monitors of rhythm a nested case‐control study....
DC (dendritic cells) play an important role in the immune system. They invade peripheral tissues to detect harmful antigens, inducing a local response. Studies suggest that DCPs cell precursors) might be reduced AMI (acute myocardial infarction); however, reason for their reduction is unknown yet. In present study, circulating mDCPs (myeloid DCPs), pDCPs (plasmacytoid tDCPs (total DCPs) and serum levels of TNFα (tumour necrosis factor α), IL (interleukin)-2, -4, -5, -6, -10 -12 were analysed...
Following COVID-19, patients often present with ongoing symptoms comparable to chronic fatigue and subjective deterioration of exercise capacity (EC), which has been recently described as postacute COVID-19 syndrome.To objectify the reduced EC after evaluate for pathologic limitations.Thirty limitation performed cardiopulmonary testing (CPET). If objectively limited in or deteriorated oxygen pulse, we offered cardiac stress magnetic resonance imaging (MRI) a follow-up CPET.Eighteen male 12...
Chronic heart failure (CHF) represents a major cause of hospitalization and death. Recent evidence shows that novel biomarkers such as soluble suppression tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), urokinase plasminogen activator receptor (suPAR) heart-type fatty acid binding protein (H-FABP) are correlated with inflammatory ischemic responses in CHF patients. In this study we examined the effects Ivabradine inhibited hyperpolarization-activated cyclic nucleotide-gated...
While COVID-19 affects the cardiovascular system, potential clinical impact of biomarkers on predicting outcomes in patients is still unknown. Therefore, to investigate this issue we analyzed prognostic cardiac in-hospital and long-term post-discharge mortality with pneumonia.Serum soluble ST2, VCAM-1, hs-TnI were evaluated upon admission 280 consecutive hospitalized COVID-19-associated pneumonia a single, tertiary care center. Patient laboratory characteristics concentration correlated...
Background: Heart failure with preserved ejection fraction (HFpEF) remains an ongoing therapeutic and diagnostic challenge to date. In this study we aimed for analysis of the potential four novel cardiovascular biomarkers, GDF-15, H-FABP, sST2, suPAR in HFpEF patients compared controls as well ICM, DCM. Methods: total, included 252 stable outpatients (77 DCM, 62 18 HFpEF, 95 controls) present study. All were a non-decompensated state on treatment regimen. Serum samples obtained analyzed...
Abstract Aims Myocarditis is associated with formidable symptoms and increased risk of adverse outcomes. Current approaches mostly rely on symptomatic treatments, warranting novel concepts for clinical practice. The aim this study was to investigate the microRNA (miRNA) expression profile Balb/c mice experimental autoimmune myocarditis (EAM), choose a representative miRNA antagonize after review available literature test its effects myocardial inflammation in vitro vivo. Methods results...
Cardiovascular events are common in COVID-19. While the use of anticoagulation during hospitalization has been established current guidelines, recommendations regarding antithrombotic therapy post-discharge period conflicting. To investigate this issue, we conducted a retrospective follow-up (393 ± 87 days) 1,746 consecutive patients, hospitalized with and surviving COVID-19 pneumonia at single tertiary medical center between April December 2020. Survivors received either 30-day treatment...
Interleukin (IL)-16, a polypeptide cytokine, plays crucial role in the inflammatory process, acting as chemoattractant for peripheral immune cells and has been linked to various diseases. However, its patients with acute myocardial infarction (AMI) is unclear. We retrospectively analyzed serum levels of IL-16 blood (STEMI, n = 45) without ST-segment elevation (NSTEMI, 42) compared controls excluded coronary artery disease (n 55). Furthermore, correlation analysis cells, C-reactive protein...
Peripheral arterial disease (PAD) is one of the most common manifestations systemic atherosclerosis. The prevalence unrecognized PAD high, leading to a lack opportunity detect subjects at high risk for cardiovascular events. Inflammatory processes play an important role in initiation as well progression. Vascular cell adhesion molecule 1 (VCAM-1), biomarker endothelial dysfunction, appears be mediator inflammatory processes. Therefore, we hypothesized that patients with PAD, circulating...
Abstract Aims Dendritic cells (DCs) are central mediators of adaptive immunity, and there is growing evidence their role in myocardial inflammatory disease. We hypothesized that plasmacytoid myeloid DCs involved the mechanisms myocarditis analysed these two main subtypes human subjects, as well a murine model experimental autoimmune (EAM). Methods results Circulating were by flow cytometry patients with acute myocarditis, dilated cardiomyopathy, controls. Myocardial biopsies immunostained...
During exposure to high altitude, the immune system is altered. hypoxia, an increase in interleukin (IL)-6 and sensitivity C-reactive protein (hs-CRP), natural killer cells decrease T blood was shown. However, impact of hypoxia on dendritic has not been investigated yet.Twelve healthy volunteers were subjected a transient normobaric for 6·5 h simulating oxygen concentration at 5500 m. samples collected analysed by flow cytometrical cell sorting (FACS) circulating myeloid (mDCs) plasmacytoid...
Background . Inflammation plays a crucial role in the progression of chronic heart failure (CHF). Ivabradine is known to reduce morbidity and mortality patients with CHF under certain conditions. Beyond reduction rate, only limited knowledge exists about potential anti-inflammatory effects ivabradine that might contribute its benefit CHF. Thus, present study aimed investigate effect on systemic inflammation. Methods In study, 33 due dilated, ischemic, hypertensive cardiomyopathy were treated...
Severe COVID-19 pneumonia requiring intensive care treatment remains a clinical challenge to date. Dexamethasone was reported as promising option, leading reduction of mortality rates in severe disease. However, the effect dexamethasone on cardiac injury and pulmonary embolism largely elusive.In total 178 critically ill patients mechanical ventilation were recruited three European medical centres included present retrospective study. One hundred thirteen (63.5%) treated with for median...
Introduction Fetuin‐A has been described to correlate inversely with vascular calcification both in animal models but also patients heart and renal disease. In this current study, we sought investigate whether fetuin‐A might be a useful marker for the discrimination of ischemic ( ICM ) from dilated cardiomyopathy DCM ). Methods A total 124 non‐consecutive were included 59 suffered 65 . Serum samples obtained during out‐patient visits analyzed by ELISA Results Median concentration overall...
Hypoxia is known to affect the immune system. It leads an increase in pro-inflammatory cytokines such as interleukin-6 and influences number of different inflammatory cells. This study investigates effect hypoxia on subsets circulating human dendritic cells (DCs) professional antigen-presenting cells.The DCs was determined via Fluorescence activated cell sorting analysis peripheral blood 17 healthy volunteers (age 35.9±2.6 years) normoxia (baseline, BL), (altitude 3000 m, alpine passive...
Hypoxia has been shown to induce a microvascular inflammation, affect the cell count of different types immune cells, and influence cytokine production in blood. In present study, serum levels cytokines were investigated achieve insights into effect hypoxia on balance inflammation anti-inflammation.Pro- (IL-8) anti-inflammatory (IL-10) measured an experiment exposing 12 healthy subjects (35 ± 9 yr, 176 7 cm, 73 16 kg, BMI 23 4 kg/m2) systemic, normobaric hypoxic chamber. this chamber oxygen...