A5074078192- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Occupational Health and Performance
- Cardiovascular and exercise physiology
- Inflammatory Bowel Disease
- Vitamin C and Antioxidants Research
- Digital Holography and Microscopy
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Respiratory Support and Mechanisms
- Thermal Regulation in Medicine
- COVID-19 and Mental Health
- Cardiovascular Effects of Exercise
- Innovations in Medical Education
- COVID-19 and healthcare impacts
- Health and Medical Research Impacts
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Photoacoustic and Ultrasonic Imaging
- Immunotherapy and Immune Responses
- COVID-19 Digital Contact Tracing
- Viral Infections and Outbreaks Research
- Immune responses and vaccinations
- Inflammasome and immune disorders
- Diabetes and associated disorders
University Hospital Münster
2020-2024
Augenstern
2021
Klinik für Schlafmedizin
2020
Justus-Liebig-Universität Gießen
2018-2019
COVID-19 is a pandemic disease that causes severe pulmonary damage and hyperinflammation. Vitamin A crucial factor in the development of immune functions known to be reduced cases acute inflammation. This prospective, multicenter observational cross-sectional study analyzed vitamin plasma levels SARS-CoV-2 infected individuals, 40 hospitalized patients were included. Of these, 22 developed critical (Acute Respiratory Distress Syndrome [ARDS]/Extracorporeal membrane oxygenation [ECMO]), 9...
With increasing numbers of patients recovering from COVID-19, there is evidence for persistent symptoms and the need follow-up studies. This retrospective study included without comorbidities, who recovered COVID-19 attended an outpatient clinic at a university hospital care potential convalescent plasma donation. Network analysis was applied to visualize symptom combinations symptoms. Comprehensive lab-testing ascertained each analyze differences regarding with vs 116 were included, age...
The clinical course of COVID-19 is very heterogeneous: most infected individuals can be managed in an outpatient setting, but a substantial proportion patients requires intensive care, resulting high rate fatalities. We performed biomarker study to assess the impact prior infections with seasonal coronaviruses on severity. Sixty confirmed were included (age 30–82; 52 males, 8 females): 19 inpatients critical disease, 16 severe or moderate and 25 outpatients. Patients disease had...
Objective Infection with the novel coronavirus SARS–CoV‐2 triggers severe illness high mortality in a subgroup of patients. Such critical course COVID‐19 is thought to be associated development cytokine storm, condition seen macrophage activation syndrome (MAS) and secondary hemophagocytic lymphohistiocytosis (HLH). However, specific data demonstrating clear association storm are still lacking. The aim this study was directly address whether immune does indeed mimic conditions found these...
The vast majority of COVID-19 patients experience a mild disease. However, minority suffers from critical disease with substantial morbidity and mortality. To identify individuals at risk COVID-19, the relevance seroreactivity against seasonal human coronaviruses was analyzed. We conducted multi-center non-interventional study comprising 296 confirmed SARS-CoV-2 infections four tertiary care referral centers in Germany France. ICU group comprised more males, whereas outpatient contained...
Understanding the course of antibody response directed to individual epitopes SARS-CoV-2 proteins is crucial for serological assays and establishment vaccines. Twenty-one synthetic peptides were synthesized that have ten amino acids overlap cover complete membrane (M) protein. Plasma samples from 32 patients having acute disease 30 convalescent phase studied. Only peptide M01 (aa 1–20) a lesser extent M21 201–222) showed specific reactivity as compared historical control plasma samples....
The COVID-19 pandemic is caused by the SARS CoV-2 virus and can lead to severe lung damage hyperinflammation. In context of infection, inflammation-induced degradation glycocalyx layer in endothelial cells has been demonstrated. Syndecan-1 (SDC-1) an established parameter for measuring injury. This prospective, multicenter, observational, cross-sectional study analyzed SDC-1 levels 24 convalescent patients that had infected with SARS-CoV-2 mild disease course without need hospitalization. We...
Severe acute respiratory syndrome coronovirus-2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19) pandemic. Vaccination considered core approach to containing There currently insufficient evidence on efficacy these vaccines in immunosuppressed inflammatory bowel (IBD) patients. The aim this study was investigate humoral response IBD patients after COVID-19 mRNA vaccination. In prospective study, IgG antibody levels (AB) against SARS-CoV-2 receptor-binding domain...
Background/Objectives: Extrapulmonary tuberculosis accounts for a significant portion of cases, presenting unique diagnostic challenges due to its heterogeneous manifestations and paucibacillary nature. This study aims fill this gap by evaluating the outcomes correlations between different specimen types test results. Methods: A retrospective analysis electronic medical records patients diagnosed with TB January 2013 December 2023 was carried out. The data extracted included patient...
Platelet autoantibody-induced platelet clearance represents a major pathomechanism in immune thrombocytopenia (ITP). There is growing evidence for clinical differences between anti-glycoprotein IIb/IIIa and Ib/IX mediated ITP. Glycoprotein V well characterized target antigen Varicella-associated drug-induced thrombocytopenia. We conducted systematic study assessing the prevalence functional capacity of autoantibodies against glycoprotein V. A total 1140 patients were included. In one-third...
Following COVID-19, patients often present with ongoing symptoms comparable to chronic fatigue and subjective deterioration of exercise capacity (EC), which has been recently described as postacute COVID-19 syndrome.To objectify the reduced EC after evaluate for pathologic limitations.Thirty limitation performed cardiopulmonary testing (CPET). If objectively limited in or deteriorated oxygen pulse, we offered cardiac stress magnetic resonance imaging (MRI) a follow-up CPET.Eighteen male 12...
Background: The prone position (PP) is increasingly used in mechanically ventilated coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) patients. However, studies investigating the influence of PP are currently lacking these This first study to investigate on oxygenation and decarboxylation COVID-19 Methods: A prospective bicentric design was used, patients, indicated from a partial pressure oxygen arterial blood (PaO2)/fraction inspired (FIO2) ratio <200....
(1) Background: Angiotensin-converting enzyme 2 (ACE2) is a functional receptor of SARS-CoV-2 and counter-balances ACE in the renin-angiotensin system (RAS). An imbalance RAS could be associated with severe COVID-19 progression. (2) Methods: Activities serum proteases angiotensin-converting (ACE) carboxypeptidase N (CPN) for 45 hospitalized 26 convalescent patients were investigated vs. healthy controls using labeled bradykinin (DBK) degradation without inhibition by captopril as read-out....
Assessing immune responses to cytomegalovirus (CMV) after liver transplant in patients on immunosuppressive therapy remains challenging. In this study, employing ELISPOT assays, 52 liver-transplant recipients were evaluated for antiviral T-cell activity peripheral blood mononuclear cells (PBMCs), measuring interferon-γ (IFN-γ) secretion upon stimulation with CMV-specific peptides (CMV peptide pool, CMV IE-1, and pp65 antigens). Parameters such as index, mean spot size, count measured. The...
(1) Background: ACE and CPN serum activity correlated with disease severity in an earlier study of 45 hospitalized COVID-19 patients. The protein profile was investigated the same cohort here to shed more light on involvement renin-angiotensin system (RAS). (2) Methods: High-definition mass spectrometry-based expression analysis performed, followed by multivariate statistical network analyses. (3) Results: profiles patients (HoP) differed significantly from those convalescent healthy...
Introduction: The Coronavirus Disease 2019 (COVID-19) pandemic has been caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). most important approach to prevent disease progression and contain is use of COVID-19 vaccines. aim this study was investigate humoral cellular response in immunosuppressed patients with inflammatory bowel (IBD) on treatment anti-TNF (infliximab, adalimumab) anti-α4ß7-Integrin (vedolizumab) 6 months after mRNA vaccination against SARS-CoV-2...
The SARS-CoV-2 virus is the causative agent of COVID-19 pandemic. disease causes respiratory failure in some individuals accompanied by marked hyperinflammation. Vitamin A (syn. retinol) can exist body storage form as retinyl ester, or transcriptionally active retinoic acid. main function retinol binding protein 4 (RBP4), synthesized liver, to transport hydrophobic vitamin various tissues. has an important role innate and acquired immune system. In particular, it involved repair lung tissue...
Patients with hematologic malignancies are at high risk of exacerbated condition and higher mortality from coronavirus disease 2019 (COVID-19). Bamlanivimab, casirivimab/imdevimab combination, sotrovimab monoclonal antibodies (mABs) that can reduce the COVID-19-related hospitalization. Clinical effectiveness bamlanivimab combination has been shown for Delta variant (B.1.617.2), but latter treatment against Omicron (B.1.1.529) suggested to be reduced. However, tolerability clinical usage...
Background.Syndecan-1 (Sdc1) is a heparin sulfate proteoglycan expressed in intestinal epithelium, which plays crucial role inflammation and epithelial repair.Sdc1-knockout mice have deteriorated course of dextran sodium-induced colitis as compared to controls.Syndecan-1 also shed into the serum during epithelium.We hypothesized that an increased level soluble Sdc1 biomarker ulcerative (UC). Objectives. To evaluate UC.Materials methods.This proof-of-concept study.Patients were recruited by...
Abstract Neutralising antibodies against the SARS-CoV-2 spike (S) protein are major determinants of protective immunity, though insufficient antibody responses may cause emergence escape mutants. We studied intra-host evolution and humoral immune response in a B-cell depleted, haemato-oncologic patient experiencing clinically severe, prolonged infection with virus lineage B.1.177.81. Bamlanivimab treatment early was associated bamlanivimab mutation S:S494P. Ten days before elimination,...
Objective: In order to be allowed use the title "Dr.med." in Germany, an independent scientific achievement under supervision of established scientist is necessary.The research question, analysis and results are essentially carried out developed independently by doctoral student.The doctorate serves as proof that candidate capable academic work.The acquisition skills knowledge particular importance medicine, Germany´s international competitiveness based on education today´s young...
Neutralising antibodies against the SARS-CoV-2 spike (S) protein are major determinants of protective immunity, though insufficient antibody responses may cause emergence escape mutants. We studied humoral immune response causing intra-host evolution in a B-cell depleted, haemato-oncologic patient experiencing clinically severe, prolonged infection with virus lineage B.1.177.81. Following bamlanivimab treatment at an early stage infection, developed bamlanivimab-resistant mutation, S:S494P....