A5043837026- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 and COVID-19 Research
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Colorectal Cancer Treatments and Studies
- Medical Imaging Techniques and Applications
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Multiple Myeloma Research and Treatments
- Genetic factors in colorectal cancer
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- Gut microbiota and health
- Virus-based gene therapy research
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
University Hospital Münster
2022-2025
University of Münster
2024-2025
Abstract Immunotherapy has revolutionized the treatment of patients with non‐small cell lung cancer (NSCLC). High expression tissue PD‐L1 (tPD‐L1) is currently only approved biomarker for predicting response. However, even tPD‐L1 low (1‐49%) and absent (<1%) might benefit from immunotherapy but, to date, there no reliable biomarker, that can predict response in this particular patient subgroup. This study aimed test whether tumour‐associated extracellular vesicles (EVs) could fill gap....
The transcriptomic classification of primary colorectal cancer (CRC) into distinct consensus molecular subtypes (CMSs) is a well‐described strategy for patient stratification. However, the nature CRC metastases remains poorly investigated. To this end, study aimed to identify and compare organotropic CMS frequencies in liver brain metastases. Compared reported CRC, from patients were CMS4‐enriched CMS3‐depleted, whereas mainly clustered as CMS3 rarely CMS4. Regarding overall survival rates,...
Background: Two-dose COVID-19 vaccination often results in poor humoral response rates patients with hematologic malignancies (HMs); yet responses to booster vaccines and the risk of infection post-booster are mostly uncertain. Methods: We included 200 outpatients HMs predominantly lymphoid neoplasms (96%, 191/200) our academic center reported on responses, which were assessed by measurement anti-spike IgG antibodies peripheral blood as early 14 days after mRNA-based prime-boost vaccination,...
Carbohydrate markers of immature cells during prenatal human development can be aberrantly expressed in cancers and deserve evaluation as immune targets. A candidate target Ewing sarcoma is the globo-series ganglioside stage-specific embryonic antigen-4 (SSEA-4). We detected SSEA-4 expression on cell surface all 14 EwS lines 21 31 (68%) primary tumor biopsies. Among paired subpopulations with low versus high expression, SSEA-4high was significantly consistently associated functional...
Patients with hematologic malignancies are at high risk of exacerbated condition and higher mortality from coronavirus disease 2019 (COVID-19). Bamlanivimab, casirivimab/imdevimab combination, sotrovimab monoclonal antibodies (mABs) that can reduce the COVID-19-related hospitalization. Clinical effectiveness bamlanivimab combination has been shown for Delta variant (B.1.617.2), but latter treatment against Omicron (B.1.1.529) suggested to be reduced. However, tolerability clinical usage...
DNA mismatch repair deficient (dMMR) and microsatellite instable (MSI) metastatic colorectal cancer (mCRC) can be successfully treated with FDA- EMA-approved immune checkpoint inhibitors (ICI) pembrolizumab nivolumab (as single agents targeting the anti-programmed cell death protein-1 (PD-1)) or combinations of a PD-1 inhibitor ipilimumab, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)-targeting antibody. The best treatment strategy beyond progression on single-agent ICI therapy...
COVID-19 vaccines have become an integral element in the protection of cancer patients against SARS-CoV-2. To date, there are no direct comparisons course infection between pre- and post-vaccine era. We analyzed SARS-CoV-2 infections their impact on vaccinated non-vaccinated from three German centers. Overall, 133 with were enrolled eras: 84 49 vaccinated, respectively. A mild was documented more frequently (49% vs. 29%), while frequency severe critical courses occurred approximately...
Abstract Cancers can aberrantly express carbohydrate antigens restricted to immature cells during prenatal human development, and these may be exploited for selective immune targeting. We studied expression functional associations of the globo-series ganglioside stage-specific embryonic antigen 4 (SSEA4), a cell surface marker stem cells, in Ewing sarcoma (EwS). Flow cytometry revealed SSEA4 on each 13 EwS lines, with moderate high densities 6 (46%) lines. Of 31 primary tumor biopsies, 21...