A5019292828- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Protein Degradation and Inhibitors
- Eosinophilic Disorders and Syndromes
- RNA modifications and cancer
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Lymphatic Disorders and Treatments
- Peptidase Inhibition and Analysis
- Gastrointestinal disorders and treatments
- Glioma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- RNA Research and Splicing
- Immunodeficiency and Autoimmune Disorders
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- T-cell and Retrovirus Studies
- RNA and protein synthesis mechanisms
- Neuroendocrine Tumor Research Advances
- Nuclear Structure and Function
Helios Hospital Berlin-Buch
2021-2024
University Medical Center Hamburg-Eppendorf
2012-2023
Universität Hamburg
2012-2023
University Cancer Center Hamburg
2010-2022
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2014
German Cancer Research Center
2009
Whether high-dose cytarabine-based salvage chemotherapy, administered to induce complete remission in patients with poor responsive or relapsed acute myeloid leukaemia scheduled for allogeneic haematopoietic stem-cell transplantation (HSCT) after intensive conditioning confers a survival advantage, is unclear. To test chemotherapy before HSCT, aged between 18 and 75 years non-favourable-risk not first induction untreated relapse were randomly assigned 1:1 cytarabine (3 g/m2 intravenously, 1...
Previously, addition of isatuximab (Isa) to standard-of-care lenalidomide-bortezomib-dexamethasone (RVd) in transplant-eligible patients with newly diagnosed multiple myeloma the GMMG-HD7 trial (ClinicalTrials.gov identifier: NCT03617731) resulted a significant increase minimal residual disease negativity (MRD-) rates after induction therapy. A total 662 were randomly assigned receive therapy Isa-RVd (n = 331) or RVd 329), followed by single tandem autologous stem-cell transplant and second...
The exon–exon junction complex (EJC) forms via association of proteins during splicing mRNA in a defined manner. Its organization provides link between biogenesis, nuclear export, and translation the transcripts. EJC accumulate speckles alongside most other splicing-related factors. We followed establishment on by investigating mobility interactions representative set factors vivo using complementary analysis with different fluorescence fluctuation microscopy techniques. Our observations are...
Abstract We subjected 90 patients covering a biological spectrum of plasma cell dyscrasias (monoclonal gammopathy undetermined significance (MGUS), amyloid light-chain (AL) amyloidosis and multiple myeloma) to next-generation sequencing (NGS) gene panel analysis on unsorted bone marrow. A total 64 different mutations in 8 genes were identified this cohort. NRAS (28.1%), KRAS (21.3%), TP53 (19.5%), BRAF (19.1%) CCND1 (8.9%) the most commonly mutated all patients. Patients with non-myeloma...
8000 Background: In medically fit patients with newly diagnosed (ND) multiple myeloma (MM), triplet or quadruplet induction regimens, high-dose chemotherapy (HDT) and autologous stem cell transplant (ASCT) remain a standard of care. Carfilzomib (K), lenalidomide (R) dexamethasone (d, KRd) induction/consolidation has proven exceptionally effective. Elotuzumab (E), an anti-SLAMF-7 monoclonal antibody bears favorable tolerability in relapsed/refractory MM while its role NDMM remains unclear....
Epstein-Barr virus (EBV) is an oncogenic found in about 95% of endemic Burkitt lymphoma (BL) cases. In latently infected cells, EBV DNA mostly maintained episomal form, but it can also be integrated into the host genome, or both forms coexist cells.In this study, we mapped chromosomal integration sites (EBV-IS) genome 21 EBV+ BL cell lines (BL-CL) using metaphase fluorescence situ hybridization (FISH). The data were used to investigate EBV-IS distribution pattern BL-CL, its relation...
Abstract Characteristic features of disseminated intravascular coagulation (DIC) are the opposing risks bleeding (due to consumptive coagulopathy and hyperfibrinolysis) organ failure widespread microvascular thromboses). The purpose anticoagulation in DIC is attenuate excessive thrombin generation fibrin deposition. While heparins have been shown be beneficial this context, safety efficacy direct oral anticoagulants not yet sufficiently addressed. Here, we report two patients whom chronic...
<b><i>Background:</i></b> Xeroderma pigmentosum (XP) is an autosomal recessive inherited disease characterized by extreme sensitivity to sunlight. Normal individuals harboring XPD polymorphisms are at increased risk for developing acute lymphoblastic leukemia and myeloid (AML). <b><i>Case Report:</i></b> A 33-year-old male XP patient was diagnosed with megakaryoblastic a complex karyotype. He received standard induction chemotherapy cytarabine...
Richter's transformation induces an aggressive clinical course in chronic lymphocytic leukemia (CLL). In the majority of cases, manifests itself as a high‑grade B‑cell non‑Hodgkin's lymphoma (B‑NHL). However, other histological types, such classical Hodgkin (cHL), lymphoblastic lymphoma, hairy cell and T‑cell NHL have been described previously. The present study reports rare case CLL with into Hodgkin's (cHL). common clonal origin cHL was documented by immunoglobulin gene rearrangement...
Chylothorax is defined as chyle entering the pleural space. The most common causes of chylothorax are lymphoma followed by bronchogenic carcinoma and trauma.We report a case in patient with Hodgkin's lymphoma. A 28-year old man was admitted to hospital exertional dyspnea dry cough. chest X-ray showed large opacity on left side suggesting presence effusion.The effusion drained, biochemical tests fluid revealed high contents triglycerides and, hence, confirmed diagnosis chylothorax. Cytology...
Abstract Objectives Dual platelet inhibition is commonly used for prevention of cardiovascular events in patients undergoing neuroendovascular procedures. Non-responsiveness to inhibitors may be associated with adverse outcomes. The aim this study was evaluate the reliability function analyzer PFA-100 ® comparison light transmittance aggregometry (LTA) monitoring clopidogrel and acetylsalicylic acid (ASA) non-responsiveness a cohort treated intracranial aneurysm or cranial artery stenosis....
<b><i>Background:</i></b> Aggressive non-Hodgkin lymphomas with secondary central nervous system (CNS) involvement bear a dismal prognosis. Optimal treatment remains so far unclear, and effective options remain an unmet clinical need. Remission rates are in general low, resulting rapid relapses palliative care the majority of patients. High-intensity combining CNS-directed chemoimmunotherapy autologous stem cell transplantation was shown recent phase 2 trial to induce...
Background: Extramedullary plasma cell (PC) disorders may occur as extramedullary disease in multiple myeloma (MM-EMD) or primary plasmocytoma (pEMP)/solitary osseous (SOP). In this study, we aimed to obtain insights into the molecular mechanisms of spread clonal PC. Methods: Clinical and biological characteristics 87 patients with MM-EMD (n = 49), pEMP/SOP 20) classical MM 18) were analyzed by using immunohistochemistry (CXCR4, CD31, CD44 CD81 staining) cytoplasmic immunoglobulin staining...
Abnormalities of the long arm chromosome 1 (1q) represent most frequent secondary chromosomal aberrations in Burkitt lymphoma (BL) and are observed almost exclusively EBV-negative BL cell lines (BL-CLs). To verify abnormalities, we cytogenetically investigated patient material, to elucidate 1q gain impact on gene expression, performed qPCR with six 1q-resident genes analyzed miRNA expression BL-CLs. We form duplications, inverted isodicentric idic(1)(q10), accumulation 1q12 breakpoints,...
Background: Progression of chronic myeloid leukemia (CML) is frequently accompanied by cytogenetic evolution, with an extra copy the Philadelphia chromosome, trisomy 8 and 19, isochromosome (17p) commonly detected. Translocations involving 11q23 chromosomal region have been rarely reported in CML. The few patients blast crisis (BC) CML carrying 11q rearrangement insufficient responses to tyrosine kinase inhibitors (TKIs) possess a poor prognosis. Case report: We report case 30-year-old man...