A5024135676- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Vitamin K Research Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Salivary Gland Disorders and Functions
- Long-Term Effects of COVID-19
- Congenital Anomalies and Fetal Surgery
- Mosquito-borne diseases and control
- Blood disorders and treatments
- Cancer Cells and Metastasis
- Travel-related health issues
- Health Systems, Economic Evaluations, Quality of Life
- Mechanical Circulatory Support Devices
- Malaria Research and Control
- Dermatological diseases and infestations
- Reproductive Biology and Fertility
- Protease and Inhibitor Mechanisms
- Blood transfusion and management
- Vector-borne infectious diseases
University Medical Center Hamburg-Eppendorf
2021-2025
Universität Hamburg
2021-2025
University of Lübeck
2019-2023
Kiel University
2021
University Hospital Schleswig-Holstein
2019-2020
Universitätsklinikum Erlangen
2014
Long-term sequelae may occur after SARS-CoV-2 infection. We comprehensively assessed organ-specific functions in individuals mild to moderate infection compared with controls from the general population.Four hundred and forty-three mainly non-hospitalized were examined median 9.6 months first positive test matched for age, sex, education 1328 a population-based German cohort. pulmonary, cardiac, vascular, renal, neurological status, as well patient-related outcomes. Bodyplethysmography...
Abstract Contact activation refers to the process of surface-induced factor XII (FXII), which initiates blood coagulation and is captured by activated partial thromboplastin time (aPTT) assay. Here, we show mechanism diagnostic implications FXII contact activation. Screening recombinant mutants identified a continuous stretch residues Gln317–Ser339 that was essential for surface binding activation, thrombin generation coagulation. Peptides spanning these 23 competed with Although lacking...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a remarkable kidney tropism. While effects are common in severe disease 2019 (COVID-19), data on non-severe courses limited. Here we provide multilevel analysis of outcomes after COVID-19 to test for eventual sequela.This cross-sectional study investigates individuals and matched controls recruited from the Hamburg City Health Study (HCHS) its program. The HCHS is prospective population-based cohort within city Hamburg,...
The aim of the current study is to investigate association between periodontitis (exposure variable) and depression severity (outcome in an older German population. We evaluated data from 6,209 participants (median age 62 years) Hamburg City Health Study (HCHS). HCHS a prospective cohort registered at ClinicalTrial.gov (NCT03934957). Depression were assessed with 9-item Patient Questionnaire (PHQ-9). Periodontal examination included probing depth, gingival recession, plaque index, bleeding...
BACKGROUND Massive hemorrhage usually results in rapid need of blood products. Patients fresh frozen plasma (FFP) might benefit from shorter thawing times using a novel radio wave device. So far, only one study on the prototype has been published. Activities clotting factors after FFP with device and system water cushions were compared. This is first analyzing quality fully developed UFT100. STUDY DESIGN AND METHODS Thirty units thawed UFT100 Plasmatherm machine. Various inhibitors analyzed...
Background: Congenital factor VII (FVII) deficiency, a rare bleeding disorder resulting from mutations in the F7 gene with autosomal recessive inheritance, exhibits clinical heterogeneity that lacks strong correlation FVII:C levels. The objective of this study was to discern genetic defects and assess their associations phenotype substantial cohort comprising 785 white women exhibiting levels below age-dependent cut-off percentage. Patients Methods: Individuals verified inherited deficiency...
Calibrated Automated Thrombography (CAT) is a versatile and sensitive method for analyzing coagulation reactions culminating in thrombin generation (TG). Here, we present CAT TG murine whole blood by adapting the assay used measuring human plasma. The diagnostically artificial physiologic factor XII (FXII) contact activators kaolin, ellagic acid polyphosphate (polyP) stimulated dose-dependent manner resulting gradual increase endogenous potential peak thrombin, with shortened lag times to...
Uncontrolled hemorrhage in polytrauma patients usually results rapid need of blood products. Despite the shorter thawing times microwave devices for heating fresh frozen plasma (FFP), their use has remained controversial, and just a few laboratory analyses have been published on this topic. The aim study was to analyse quality clotting factors immediately after FFP with device 48-hour post thaw storage at 4 degrees C.24 units all four ABO groups (six each group) were thawed Transfusio-therm...
The role of the A>G polymorphism at position 19911 in prothrombin gene (factor [F] 2 rs3136516) as a risk factor for venous thromboembolism [VTE] is still unclear. To evaluate presence F2 VTE patients compared to healthy blood donors and adjust results common inherited thrombophilias [IT], age onset group [BG], calculate recurrence. We investigated 1012 Caucasian with diagnosis rs3136516 these 902 donors. Odds ratios [OR] together their 95% confidence intervals were calculated adjusted F5...
Abstract Background Coagulopathy is common in acute symptomatic Plasmodium falciparum malaria, and the degree of coagulation abnormality correlates with parasitemia disease severity. Chronic asymptomatic malaria has been associated increased morbidity. However, role activation asymptomatic, semi-immune individuals remains unclear. This study investigates potential effect P infection on Ghanaian adults. Methods Blood from adults blood stage detectable by polymerase chain reaction (PCR) or...
Acute kidney injury (AKI) after transcatheter aortic valve implantation (TAVI) is a serious complication which associated with increased mortality. The RenalGuard system was developed to reduce the risk of AKI contrast media exposition by furosemide-induced diuresis matched isotonic intravenous hydration. aim this study examine effect on occurrence TAVI in patients chronic disease.
Protein S (PS) is an important anticoagulant. Its main function to act as a non-enzymatical cofactor of activated protein C. PS deficiency defined low plasma levels and/or loss associated with variable risk venous thromboembolism (VTE). We report 2 novel variants in the gene (PROS1) which are and severe thrombophilic diathesis patients. Patient 1 suffered from 3 VTE events, including spontaneous at age 19. provoked events. In both patients decreased antigen well activity were found. Gene...
The number of homeless people in Germany is steadily increasing. Due to their often precarious living conditions, this specific population may be increasingly exposed ectoparasites that can transmit various pathogens. To assess the prevalence and thus risk such infections, we analyzed seropositivity rickettsiosis, Q fever, tularemia bartonellosis individuals.A total 147 adults from nine shelters Hamburg, Germany, were included. individuals underwent questionnaire-based interviewing, physical...
Introduction The condensed MCMDM-1 Bleeding Questionnaire score has originally been designed to investigate for type 1 von Willebrand Disease (VWD). However, its diagnostic utility in detecting other hemorrhagic disorders is unknown. Since patients with a suspected bleeding diathesis usually undergo an extensive laboratory assessment including platelet function tests and measurement of coagulation factor activities, we wanted assess the association between VWD parameters.
For cryopreservation of stem cells, a cryoprotective agent is essential. Dimethyl sulfoxide commonly used, but has deleterious effects on cell vitality in the warmth and for recipients cells. The aim study was to reduce DMSO find one solution suitable cells different origin. Materials: Small volumes both apheresis products cord blood derived were frozen using six solutions. Suitability these solutions tested by comparing vitalities recovery rates CD45 CD34 positive colony forming unit...
Aufgrund verbesserter Betreuungs- und Therapiemöglichkeiten sind Lebenserwartung Mobilität von Hämophiliepatienten in den letzten Jahrzehnten deutlich gestiegen. Obwohl Patienten mit Hämophilie zumeist speziellen Hämophiliezentren primär betreut werden, können sollten diese aufgrund besonderer medizinischer Risiken im Reiseland zur reise- tropenmedizinischen Beratung bei einem Reise- oder Tropenmediziner vorstellig werden. In dieser Übersicht werden reisemedizinisch relevante Aspekte zu...
es ist unstrittig, dass der Fortschritt Medizin in Verbindung mit verbesserten Lebensbedingungen zu einer Verlängerung Lebenszeit von Menschen führt. Die reine Lebenszeit, das Überleben als solches, steht jedoch hochentwickelten Industriegesellschaften nicht mehr im Zentrum medizinischen Handelns. Vielmehr kommt darauf an, Ergebnis ein möglichst hohes Maß an Lebensqualität bis hohe Alter hinein gewährleisten. Gleiches gilt für chronischen Erkrankungen, völlig unabhängig des Lebensalters.