A5050713930- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Machine Learning in Healthcare
- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- MRI in cancer diagnosis
- Neurological and metabolic disorders
- Cerebrovascular and Carotid Artery Diseases
- Schizophrenia research and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Folate and B Vitamins Research
- Cerebrovascular and genetic disorders
- COVID-19 Clinical Research Studies
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Retirement, Disability, and Employment
- Nutritional Studies and Diet
- Cardiovascular Health and Disease Prevention
- Sleep and Work-Related Fatigue
- Neuroscience and Music Perception
- Neurotransmitter Receptor Influence on Behavior
University Medical Center Hamburg-Eppendorf
2019-2025
Universität Hamburg
2019-2025
Innsbruck Medical University
2024
Brigham and Women's Hospital
2019-2022
Harvard University
2019-2022
Eppendorf (Germany)
2022
Long-term sequelae may occur after SARS-CoV-2 infection. We comprehensively assessed organ-specific functions in individuals mild to moderate infection compared with controls from the general population.Four hundred and forty-three mainly non-hospitalized were examined median 9.6 months first positive test matched for age, sex, education 1328 a population-based German cohort. pulmonary, cardiac, vascular, renal, neurological status, as well patient-related outcomes. Bodyplethysmography...
As severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infections have been shown to affect the central nervous system, investigation of associated alterations brain structure and neuropsychological sequelae is crucial help address future health care needs. Therefore, we performed a comprehensive neuroimaging assessment 223 nonvaccinated individuals recovered from mild moderate SARS-CoV-2 infection (100 female/123 male, age [years], mean ± SD, 55.54 7.07; median 9.7 mo after...
In cerebral small vessel disease (CSVD), both white matter hyperintensities (WMH) of presumed vascular origin and the normal-appearing (NAWM) contain microstructural brain alterations on diffusion-weighted MRI (DWI). Contamination DWI-derived metrics by extracellular free-water can be corrected with (FW) imaging. We investigated in FW FW-corrected fractional anisotropy (FA-t) WMH surrounding tissue their association cerebrovascular risk factors. analysed 1,000 datasets from Hamburg City...
Age-related cortical atrophy, approximated by thickness measurements from magnetic resonance imaging, follows a characteristic pattern over the lifespan. Although its determinants remain unknown, mounting evidence demonstrates correspondence between connectivity profiles of structural and functional brain networks atrophy in health neurological disease. Here, we performed cross-sectional multimodal neuroimaging analysis 2633 individuals large population-based cohort to characterize...
Kidney dysfunction (KD) is a risk factor for cerebrovascular events and has been shown to have detrimental effect on outcome after stroke. We evaluated the influence of KD at admission pre-existing diagnosis chronic kidney disease (CKD) before thrombectomy anterior circulation stroke functional independence mortality 90 days in this cross-sectional study.
In this study we explore the spatio-temporal trajectory and clinical relevance of microstructural white matter changes within beyond subcortical stroke lesions detected by free-water imaging. Twenty-seven patients with infarct mean age 66.73 (SD 11.57) median initial NIHSS score 4 (IQR 3-7) received diffusion MRI 3-5 days, 1 month, 3 months, 12 months after symptom-onset. Extracellular fractional anisotropy tissue (FA
Objectives It is important to find biomarkers associated with transition illness in individuals at clinical high-risk for psychosis (CHR). Here, we use free-water imaging, an advanced diffusion MRI technique, identify white matter alterations the brains of CHR subjects who subsequently develop (CHR-P) compared those do not (CHR-NP).Methods Twenty-four healthy controls (HC) and 30 individuals, 8 whom converted schizophrenia after a mean follow-up 15.16 months, received baseline scans. Maps...
Abstract Background While adolescent-onset schizophrenia (ADO-SCZ) and bipolar disorder with psychosis (psychotic ADO-BPD) present a more severe clinical course than their adult forms, pathophysiology is poorly understood. Here, we study potentially state- trait-related white matter diffusion-weighted magnetic resonance imaging (dMRI) abnormalities along the continuum to address this need. Methods Forty-eight individuals ADO-SCZ (20 female/28 male), 15 psychotic ADO-BPD (7 female/8 35...
Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association microstructural brain alterations is unclear. To address this, we examined the MRI parameters representing vascular damage, neurodegeneration, and integrity in 2316 participants population-based Hamburg City Health Study. Cortical thickness white matter hyperintensity (WMH) load were measured on FLAIR T1-weighted images. Microstructural was quantified as peak width skeletonized mean...
The aim of the PAROBRAIN study was to examine association periodontal health with microstructural white matter integrity and cerebral small vessel disease (CSVD) in Hamburg City Health Study, a large population-based cohort dental examination brain magnetic resonance imaging (MRI).Periodontal determined by measuring clinical attachment loss (CAL) plaque index. Additionally, decayed/missing/filled teeth (DMFT) index quantified. 3D-FLAIR 3D-T1-weighted images were used for hyperintensity (WMH)...
Objective: Sexual dimorphism has been investigated in schizophrenia, although sex-specific differences among individuals who are at clinical high-risk (CHR) for developing psychosis have inconclusive. This study aims to characterize sexual of language areas the brain by investigating asymmetry four white matter tracts relevant verbal working memory CHR patients compared healthy controls (HC). HC typically show a leftward these tracts. Moreover, structural abnormalities and dysfunctions...
Objectives: Disrupted auditory networks play an important role in the pathophysiology of psychosis, with abnormalities already observed individuals at clinical high-risk for psychosis (CHR). Here, we examine structural and functional connectivity network CHR utilising state-of-the-art electroencephalography diffusion imaging techniques.Methods: Twenty-six subjects 13 healthy controls (HC) underwent MRI while performing task. We investigated connectivity, measured as fractional anisotropy...
The link between metabolic syndrome (MetS) and neurodegenerative as well cerebrovascular conditions holds substantial implications for brain health in at-risk populations. This study elucidates the complex relationship MetS by conducting a comprehensive examination of cardiometabolic risk factors, morphology, cognitive function 40,087 individuals. Multivariate, data-driven statistics identified latent dimension linking more severe to widespread morphological abnormalities, accounting up 71%...
The link between metabolic syndrome (MetS) and neurodegenerative as well cerebrovascular conditions holds substantial implications for brain health in at-risk populations. This study elucidates the complex relationship MetS by conducting a comprehensive examination of cardiometabolic risk factors, cortical morphology, cognitive function 40,087 individuals. Multivariate, data-driven statistics identified latent dimension linking more severe to widespread morphological abnormalities,...
<title>Abstract</title> The human’s heart responds to tissue damage with persistent fibrotic scarring. Unlike humans, zebrafish exhibit the ability repair cardiac injury and re-grow throughout life. Here, we provide novel evidence for <italic>toll-like receptor 3 (tlr3)</italic> driving regeneration in zebrafish. Upon injury, survival is decreased <italic>tlr3</italic><sup><italic>-/-</italic></sup> fish<italic> </italic>as compared wildtype controls....
The link between metabolic syndrome (MetS) and neurodegenerative as well cerebrovascular conditions holds substantial implications for brain health in at-risk populations. This study elucidates the complex relationship MetS by conducting a comprehensive examination of cardiometabolic risk factors, morphology, cognitive function 40,087 individuals. Multivariate, data-driven statistics identified latent dimension linking more severe to widespread morphological abnormalities, accounting up 71%...
The association of shift work (SW) and disrupted circadian rhythm with markers large artery atherosclerosis cerebral small vessel disease is uncertain. We aimed to study the separate current former SW these markers.
Background Blood-brain barrier (BBB) leakage measured with dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) has been associated hemorrhagic transformation in acute ischemic stroke (AIS). However, the influence of pre-thrombolysis BBB on infarct growth not studied. Therefore, we aimed to characterize integrity according tissue state at admission and fate follow-up MRI. Methods This is a post-hoc analysis Efficacy Safety MRI-Based Thrombolysis Wake-Up Stroke (WAKE-UP) trial...