A5046542603- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- Cardiovascular Disease and Adiposity
- Signaling Pathways in Disease
- SARS-CoV-2 and COVID-19 Research
- Pancreatic function and diabetes
- Animal Genetics and Reproduction
- COVID-19 Clinical Research Studies
Innsbruck Medical University
2022-2024
Universität Innsbruck
2022-2024
VASCage
2024
The prognosis of COVID-19 patients with cardiac involvement is unfavorable and it remains unknown which are at risk. virus enters cells via its receptor angiotensin-converting enzyme 2 (ACE2). Myocardial ACE2 expression increased in structural heart disease (SHD). We, therefore, aimed to analyze correlations between SARS-CoV-2 manifestation.The clinical course was assessed a prospective cohort 152 patients. primary endpoints consisted hospitalization survival. Cardiac tissue 23 autopsy cases...
Abstract The human’s heart responds to tissue damage with persistent fibrotic scarring. Unlike humans, zebrafish can repair cardiac injury and re-grow throughout life. Recently, Toll-like receptor 3 ( Tlr3 ) was identified as an important mediator of regeneration in neonatal mice. However, no functional analysis tlr3 knock-out mutant respect has yet been performed. We hypothesize that TLR3 signalling plays a central, conserved role driving upon injury. Therefore, we focused on mediated...
<title>Abstract</title> The human’s heart responds to tissue damage with persistent fibrotic scarring. Unlike humans, zebrafish exhibit the ability repair cardiac injury and re-grow throughout life. Here, we provide novel evidence for <italic>toll-like receptor 3 (tlr3)</italic> driving regeneration in zebrafish. Upon injury, survival is decreased <italic>tlr3</italic><sup><italic>-/-</italic></sup> fish<italic> </italic>as compared wildtype controls....
Coordinated signaling pathway activity directs early patterning to set up the vertebrate body plan. Perturbations in timing or location of signal molecule expression impacts embryo morphology and organ formation. In this study, we present a laboratory course use zebrafish for studying role Wnt specifying embryonic axes. Students are exposed basic techniques molecular developmental biology, including manipulation, fluorescence microscopy, image processing, data analysis. Furthermore,...