A5079266415- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- Cancer-related molecular mechanisms research
- Retinoids in leukemia and cellular processes
- Infective Endocarditis Diagnosis and Management
- Sarcoma Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- RNA regulation and disease
- Renal and related cancers
- Developmental Biology and Gene Regulation
- Neurofibromatosis and Schwannoma Cases
- Pancreatic function and diabetes
- Cardiac Valve Diseases and Treatments
- Retinal Development and Disorders
- Genetic and Kidney Cyst Diseases
- Neuroblastoma Research and Treatments
Universität Innsbruck
2015-2024
Innsbruck Medical University
2023
Calcific aortic valve disease (CAVD) is characterized by a phenotypic switch of valvular interstitial cells to bone-forming cells. Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition at the interface between innate immunity and tissue repair. Type I interferons (IFNs) not only crucial for an adequate antiviral response but also implicated in bone formation. We hypothesized that accumulation endogenous TLR3 ligands leaflets may promote generation osteoblast-like...
Mutations in the homeobox transcription factor MNX1 are major cause of dominantly inherited sacral agenesis. Studies model organisms revealed conserved mnx gene requirements neuronal and pancreatic development while Mnx activities that could explain caudal mesoderm specific agenesis phenotype remain elusive. Here we use zebrafish pronephros as a simple yet genetically for kidney formation to uncover novel role factors nephron morphogenesis. Pronephros can formally be divided four stages,...
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft-tissue sarcomas, characterized by complex karyotypes. The molecular bases of such malignancy poorly understood and efficient targeted therapies currently lacking. Here we describe a novel zebrafish model MPNSTs, represented the transgenic mutant line Tg(-8.5nkx2.2a:GFP)ia2. ia2 homozygous animals displayed embryonic lethality 72 hpf, while heterozygotes develop visible tumor masses with high frequency in adulthood....
<title>Abstract</title> The human’s heart responds to tissue damage with persistent fibrotic scarring. Unlike humans, zebrafish exhibit the ability repair cardiac injury and re-grow throughout life. Here, we provide novel evidence for <italic>toll-like receptor 3 (tlr3)</italic> driving regeneration in zebrafish. Upon injury, survival is decreased <italic>tlr3</italic><sup><italic>-/-</italic></sup> fish<italic> </italic>as compared wildtype controls....
Retinol binding proteins (Rbps) are known as carriers for transport and targeting of retinoids to their metabolizing enzymes. Rbps also reported function in regulating the homeostatic balance retinoid metabolism, level occupancy impacts activities Here we used zebrafish a model study rbp7a regulation. We find that early embryonic expression is negatively regulated by Nodal/FoxH1-signaling pathway show Nodal/FoxH1 activity has opposite effect on aldh1a2, which encodes major enzyme retinoic...