A5024917024- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Numerical methods for differential equations
- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
- Physics and Engineering Research Articles
- Parathyroid Disorders and Treatments
- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Thyroid Disorders and Treatments
- Immunotherapy and Immune Responses
- Growth Hormone and Insulin-like Growth Factors
- Airway Management and Intubation Techniques
- Voice and Speech Disorders
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Nitric Oxide and Endothelin Effects
- Hormonal and reproductive studies
- GaN-based semiconductor devices and materials
- Fractional Differential Equations Solutions
- Differential Equations and Numerical Methods
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Corporate Governance and Management
- Renal Transplantation Outcomes and Treatments
- Engineering and Materials Science Studies
Krankenanstalt Rudolfstiftung der Stadt Wien
2013-2025
Universität Innsbruck
2015-2024
Innsbruck Medical University
2015-2024
Austrian Competence Centre of Food Safety
2024
Wiener Krankenanstaltenverbund
2023-2024
Heidelberg University
2024
University Hospital Heidelberg
2024
Fundação Centro de Hematologia e Hemoterapia de Minas Gerais
2023
VersuchsStollen Hagerbach (Switzerland)
2022
Technical University of Darmstadt
1995-2022
The macroscopic nonlinear pyroelectric polarization of wurtzite AlxGa1-xN, InxGa1-xN and AlxIn1-xN ternary compounds (large spontaneous piezoelectric coupling) dramatically affects the optical electrical properties multilayered Al(In)GaN/GaN hetero-, nanostructures devices, due to huge built-in electrostatic fields bound interface charges caused by gradients in at surfaces heterointerfaces. Models polarization-induced effects GaN-based devices so far have assumed that nitride alloys can be...
Pseudo-TORCH syndrome (PTS) is characterized by microcephaly, enlarged ventricles, cerebral calcification, and, occasionally, systemic features at birth resembling the sequelae of congenital infection but in absence an infectious agent. Genetic defects resulting activation type 1 interferon (IFN) responses have been documented to cause Aicardi-Goutières syndrome, which a PTS. Ubiquitin-specific peptidase 18 (USP18) key negative regulator I IFN signaling. In this study, we identified...
Thermal runaway and the subsequent fire of electric vehicle lithium-ion batteries cause a specific type contamination. In order to assess resulting risks damage critical infrastructure human health, we perform practical thermal experiments with battery modules an approved, commercially available vehicle. Extensive chemical analyses identify quantify soot depositions in ventilated non-ventilated rooms. Contamination mainly consists metal oxides cathode material, lithium fluoride compounds....
Objective To evaluate the effect of recurrent nerve dissection on incidence laryngeal injury (RLNI) and to analyze performance individual surgeons. Summary Background Data Dissection is mandatory in total thyroidectomy, but its relative merit less extensive resections not clear. The reported rates RLNI differ widely; this may reflect a variation Methods authors studied primary surgery for benign thyroid disease during three periods single center. In period 1 (1979–1990; 9,385 consecutive...
The pH-sensitivity of GaN surfaces in electrolyte solutions has been determined. For this purpose, field-effect transistors and AlGaN/GaN high-electron-mobility transistor (HEMT) structures were used to measure the response nonmetallized gate regions changes H+-concentration an ambient electrolyte. We found a linear pH between pH=2 pH=12 for both as-deposited thermally oxidized surfaces. Both showed almost Nernstian behavior with sensitivities 57.3 mV/pH GaN:Si/GaN:Mg 56.0 GaN/AlGaN/GaN HEMT...
We evaluated the ability of neuromonitoring to predict postoperative outcome in patients undergoing thyroid surgery for different indications.Neuromonitoring has been advocated reduce risk vocal cord palsy and function.Three hundred twenty-eight (502 nerves at risk) were studied prospectively a single center. Neuromonitoring was performed with Neurosign 100 device by transligamental placement recording electrode into vocalis muscles. Cumulative distribution stimulation thresholds determined...
Background: A growing body of evidence supports the hypotheses that retinoic acid receptor β2 (RAR-β2) gene is a tumor suppressor and chemopreventive effects retinoids are due to induction RAR-β2. RAR-β2 expression reduced in many malignant tumors, we examined whether methylation could be responsible for this silencing. Methods: was studied by reverse transcription–polymerase chain reaction (RT–PCR) analysis eight breast cancer cell lines were either treated with demethylating agent...
FOXO transcription factors induce apoptosis and regulate cellular production of reactive oxygen species (ROS). To identify the sequence molecular events underlying FOXO3 (FKHRL1)-induced apoptosis, we studied regulation function by expressing an ECFP-tagged or a 4OH-tamoxifen (4OHT)-inducible FOXO3-ERtm fusion protein in SH-EP STA-NB15 neuronal cells. After knockdown expression dominant-negative mutant observed that etoposide- doxorubicin-induced elevation ROS depends on activation induction...
Postoperative bleeding after thyroid surgery is a feared and life-threatening complication. The aim of the study was to identify risk factors for postoperative bleeding, with special emphasis on impact individual surgeon time diagnosis complication.Data consecutive operations were collected prospectively in database over 30 years analysed retrospectively potential bleeding.There 30,142 occurred 519 patients (1·7 per cent). Risk identified older age (odds ratio (OR) 1·03 year), male sex (OR...
Hashimoto's thyroiditis (HT) is a common disease, and the most prevalent cause of hypothyroidism. Symptoms diseases associated with HT are considered to be caused by We hypothesized that higher antithyroperoxidase (anti-TPO) antibody levels would an increased symptom load decreased quality life in female euthyroid patient collective.In prospective cohort study 426 consecutive patients undergoing thyroid surgery for benign disease were included. Main outcome measures preoperative anti-TPO...
OBJECTIVE To compare the intermediate‐term outcomes of patients with clinical T1a renal tumours who were treated nephron‐sparing surgery by partial nephrectomy (PN), preferred approach for small (cT1a) tumours, or radiofrequency ablation (RFA), recently offered to selected as an alternative, less morbid technique. PATIENTS AND METHODS We identified stage masses had ≥ 2 years follow‐up; those bilateral synchronous metachronous metastatic disease at presentation, a family history cell...
ROS (reactive oxygen species) generated by NADPH oxidases play an important role in cellular signal transduction regulating cell proliferation, survival and differentiation. Nox4 (NADPH oxidase 4) induces senescence human endothelial cells; however, intracellular targets for remained elusive. In the present study, we show that mitochondrial dysfunction cells. depletion induced alterations morphology, stabilized membrane potential decreased production of H(2)O(2) mitochondria. High-resolution...
Many diseases and pathological conditions are characterized by transient or constitutive overproduction of reactive oxygen species (ROS). ROS causal for ischemia/reperfusion (IR)-associated tissue injury (IRI), a major contributor to organ dysfunction failure. Preventing IRI with antioxidants failed in the clinic, most likely due difficulty timely efficiently target them site production action. IR is also changes activity intracellular signaling molecules including stress kinase p38MAPK....
Significance Although sequencing of the human genome was completed years ago, we still do not know about physiological significance thousands predicted proteins, particularly membrane proteins. On other hand, for approximately 100 enzymes, no coding gene is known even though their enzymatic reaction has been well characterized. In this work, assign one those proteins (transmembrane protein 189; TMEM189) to reactions with an uncharacterized (plasmanylethanolamine desaturase). This enzyme...
Neuroblastoma is the most common solid tumor in childhood and develops from undifferentiated progenitor cells of sympathetic nervous system. In neuronal DNA-damaging chemotherapeutic agents activate transcription factor FOXO3 which regulates formation reactive oxygen species (ROS) cell death as well a longevity program associated with therapy resistance. We demonstrated before that C10ORF10/DEPP, transcriptional target FOXO3, localizes to peroxisomes mitochondria impairs cellular ROS...
As many current approaches for heart regeneration exert unfavourable side effects, the induction of endogenous repair mechanisms in ischaemic disease is particular interest. Recently, exosomes carrying angiogenic miRNAs have been described to improve function. However, it remains challenging stimulate specific release reparative myocardium. In present study, we sought test hypothesis that physical stimulus shock wave therapy (SWT) causes exosomes. We aimed substantiate pro-angiogenic impact...
Langerhans cells are a subset of dendritic residing in the epidermis human skin. As such, they key mediators immune regulation and have emerged as prime targets for novel transcutaneous cancer vaccines. Importantly, induction protective T cell immunity by these vaccines requires efficient specific delivery both tumor-associated antigens adjuvants. uniquely express Langerin (CD207), an endocytic C-type lectin receptor. Here, we report discovery specific, glycomimetic ligand employing...
Neuroblastoma is an extracranial solid tumor which develops in early childhood and still has a poor prognosis. One strategy to increase cure rates the identification of patient-specific drug responses tissue models that mimic interaction between patient cancer cells environment. We therefore developed perfused micro-vascularized tumor-environment model directly bioprinted into custom-manufactured fluidic chips. A gelatin-methacrylate/fibrin-based matrix containing multiple cell types mimics...