A5030599078- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Birth, Development, and Health
- Infant Nutrition and Health
- Neuroscience of respiration and sleep
- Child and Adolescent Health
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Neuroblastoma Research and Treatments
- FOXO transcription factor regulation
- Pharmacological Receptor Mechanisms and Effects
- Anesthesia and Neurotoxicity Research
- Neuropeptides and Animal Physiology
- Cardiovascular Health and Disease Prevention
- Obesity, Physical Activity, Diet
- Breastfeeding Practices and Influences
- Cardiovascular Health and Risk Factors
- Receptor Mechanisms and Signaling
- Metabolism and Genetic Disorders
- Cardiovascular Conditions and Treatments
- Cardiovascular Disease and Adiposity
- Fetal and Pediatric Neurological Disorders
- Cognitive and developmental aspects of mathematical skills
- Infant Health and Development
Universität Innsbruck
2016-2025
Innsbruck Medical University
2016-2025
University Hospital Innsbruck
2001-2024
VASCage
2022
Zentrum für Kinderheilkunde
2016-2018
Medical University of Graz
2016
University Children's Hospital Zurich
2013
Universitätsklinik für Kinder und Jugendpsychiatrie
2003-2004
The transcription factor FOXO3 is associated with poor outcome in high-stage neuroblastoma (NB), as it facilitates chemoprotection and tumor angiogenesis. In other entities, stimulates metastasis formation, one of the biggest challenges treatment aggressive NB. However, impact on metastatic potential neuronal cells remains largely unknown. present study, we uncover small leucine-rich proteoglycan family member lumican (LUM) a FOXO3-regulated gene that cellular migration By drug-library...
Neuroblastoma is the most common solid tumor in childhood and develops from undifferentiated progenitor cells of sympathetic nervous system. In neuronal DNA-damaging chemotherapeutic agents activate transcription factor FOXO3 which regulates formation reactive oxygen species (ROS) cell death as well a longevity program associated with therapy resistance. We demonstrated before that C10ORF10/DEPP, transcriptional target FOXO3, localizes to peroxisomes mitochondria impairs cellular ROS...
Abstract Objective To investigate whether monitoring of cerebral tissue oxygen saturation using near infrared spectroscopy in addition to routine combined with defined treatment guidelines during immediate transition and resuscitation increases survival without injury premature infants compared standard care alone. Design Multicentre, multinational, randomised controlled phase 3 trial. Setting 11 tertiary neonatal intensive units six countries Europe Canada. Participants 1121 pregnant women...
Assessment of risk predictors for adverse neurodevelopmental outcome at 1 year age in preterm infants with a gestational <30 weeks (Group I) and 30-32 II).Between January 2003 December 2006, we prospectively enrolled 310 live-born between 23 32 gestation. The association candidate factors delayed motor or mental development (Bayley Scales infant II; psychomotor developmental index <85) was analysed by means logistic regression analysis.Two hundred fifty were eligible follow-up, 205 (82.0%)...
Abstract Aim To examine the association between neurodevelopmental outcome and head circumference (HC) in a cohort of very preterm infants this context to investigate relevance suboptimal size. Methods Somatometric data were obtained at birth, discharge 3, 12 24 months for all born Tyrol <32 weeks gestational age. Growth are presented as z scores. HC was defined microcephaly (>2 SD below mean), (>1 mean) or normal size (<1 mean). Neurodevelopmental quantified using Bayley Scales...
Aim of the study is to investigate frequency and predictors for rehospitalization within first 2 years life among preterm infants.All children born before 32 weeks gestation in Northern Tyrol between January 2003 July 2008 were prospectively enrolled. Data on rehospitalizations obtained from hospital admission records. The association candidate risk factors readmission was analysed by means logistic regression analysis.In second life, 151 93 377 (40.1% 24.7%), respectively, readmitted one...
Neonatal inspiratory stridor is an important examination finding that requires immediate and adequate evaluation of the underlying etiology. Depending on severity airway obstruction presence or absence associated symptoms such as respiratory distress feeding problems, early initiation a complete diagnostic workup can be crucial. The most common cause neonatal laryngomalacia, however, several differential diagnoses need to investigated. More rare causes include oral laryngeal masses....
Abstract: To date, appropriate skin therapy for premature infants has not been clearly defined. Emollient creams are often used without solid evidence a benefit to the neonate. The aim of current study was investigate cutaneous effects two different topical ointment therapies. Between October 2004 and November 2006 we prospectively enrolled 173 between 25 36 weeks gestation admitted neonatal intensive care unit. Infants were randomly assigned daily treatment with water‐in‐oil emollient cream...
Abstract The transcription factor FOXO3 has been associated in different tumor entities with hallmarks of cancer, including metastasis, angiogenesis, maintenance tumor-initiating stem cells, and drug resistance. In neuroblastoma (NB), we recently demonstrated that nuclear promotes angiogenesis vivo chemoresistance vitro. Hence, inhibiting the transcriptional activity is a promising therapeutic strategy. However, as no inhibitor clinically available to date, used medium-throughput...
The objectives of this study were to develop age- and sex-specific reference percentiles for fat mass index (FMI) fat-free (FFMI) in adolescents aged 14 19 years determine differences overweight/obesity classification by FMI body (BMI). EVA4YOU is a single-center cross-sectional conducted western Austria. Cardiovascular risks including anthropometric measurements bioelectrical impedance analysis assessed (mean age 17 years). FFMI calculated as the ratio (FM) (FFM) square height compared...
Abstract Aim The current study determined the neurodevelopmental outcome of extremely preterm infants at 2 years age. Methods All live‐born 23–27 weeks gestation born between 2011 and 2020 in Austria were included a prospective registry. Neurodevelopmental corrected age was assessed using Bayley Scales Infant Development for both motor cognitive scores, along with neurological examination an assessment neurosensory function. Results 2378 out 2905 (81.9%) survived to Follow‐up data available...
FOXO transcription factors control cellular levels of reactive oxygen species (ROS) which critically contribute to cell survival and death in neuroblastoma. In the present study we investigated regulation C10orf10/DEPP by factor FOXO3. As a physiological function has not been described so far analyzed its effects on ROS detoxification sensitization human neuroblastoma cells. The effect DEPP was measured catalase activity assay live fluorescence microscopy using ROS-sensitive dye reduced...
<b><i>Background:</i></b> In recent years, cerebral magnetic resonance imaging (MRI) has been increasingly used to depict the wide spectrum of preterm brain injury. Furthermore, it already demonstrated by MRI at term-equivalent age (TEA) that infants show delayed maturation as compared term infants, and this delay related neurobehavioral outcome. <b><i>Objectives:</i></b> The aim current study was investigate influence prevalent neonatal risk...
Cardiovascular disease is the leading cause of death worldwide. Evidence points towards an unfavorable cardiovascular risk profile former preterm infants in adolescence and adulthood. The aim this study was to determine whether predictors are detectable very at a preschool age. Five- seven-year-old children born <32 weeks' gestational age were included study. Same-aged term served as controls. Basic data participants collected by means follow-up databases standardized questionnaires. At...
To define percentile charts for arterial oxygen saturation (SpO
The current study aims to give an overview of transition-to-home services provided by perinatal centres in Austria and Switzerland evaluate parental satisfaction with the care provided. This cross-sectional multicentred was conducted performing two surveys between May 2022 November 2023: one among all level III (n=7) (n=9) (institutional survey) parents very preterm infants treated at selected centre each countries (parental survey). Both questionnaires consisted matching questions focusing...
Introduction After the release of Bayley Scales Infant and Toddler Development, third edition (Bayley-III), US norms, an overestimation outcome was observed. But, conformity between second (BSID-II), Bayley-III German norms is unknown. This retrospective analysis aimed to compare outcomes very preterm infants tested with BSID-II norms. Methods Infants born from November 2007 July 2018 were included. Exclusion criteria death or missing outcome. underwent testing either until December 2013...
Physical activity (PA) protects against cardiovascular disease. However, previous research has shown that high PA is associated with an increased carotid intima-media-thickness (cIMT), independent predictor for future Our aim was to further investigate this unexpected association two different measurement methods of and established markers Early Vascular Ageing: cIMT carotid-femoral pulse-wave velocity (cfPWV). The community-based Ageing-Tyrol cohort study included adolescents in western...