A5064692134- Digital Mental Health Interventions
- Advanced Breast Cancer Therapies
- Mental Health Research Topics
- Cancer Treatment and Pharmacology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Liver Disease and Transplantation
- Neonatal Respiratory Health Research
- Acute Ischemic Stroke Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer survivorship and care
- Diabetes Management and Education
- Gastrointestinal motility and disorders
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Pain Management and Opioid Use
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Neural and Behavioral Psychology Studies
- Cancer Mechanisms and Therapy
- Musculoskeletal pain and rehabilitation
- Chronic Lymphocytic Leukemia Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiac Arrhythmias and Treatments
- Prostate Cancer Diagnosis and Treatment
- Obstructive Sleep Apnea Research
University Medical Center of the Johannes Gutenberg University Mainz
2016-2025
Johannes Gutenberg University Mainz
2016-2025
University Medical Centre Mannheim
2017-2024
Institute for Regenerative Medicine & Biotherapy
2024
Inserm
2024
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2014-2023
University Medical Center
2017-2023
Klinik für Frauenheilkunde
2018
Ludwig-Maximilians-Universität München
2018
University Hospital Heidelberg
2018
<h3>Importance</h3> Internet and computer game addiction represent a growing mental health concern, acknowledged by the World Health Organization. <h3>Objective</h3> To determine whether manualized cognitive behavioral therapy (CBT), using short-term treatment for internet (STICA), is efficient in individuals experiencing addiction. <h3>Design, Setting, Participants</h3> A multicenter randomized clinical trial was conducted 4 outpatient clinics Germany Austria from January 24, 2012, to June...
<h3>Importance</h3> Intravenous edaravone is approved as a disease-modifying drug for patients with amyotrophic lateral sclerosis (ALS), but evidence efficacy limited to short-term beneficial effects shown in the MCI186-ALS19 study subpopulation which was expected. <h3>Objective</h3> To evaluate long-term safety and effectiveness of intravenous therapy ALS real-world clinical setting. <h3>Design, Setting, Participants</h3> Multicenter, propensity score–matched cohort conducted between June...
ABSTRACT Background: Opioid‐induced constipation can have a major negative impact on patients’ quality of life. This randomised, double‐blinded study evaluated the analgesic efficacy prolonged‐release (PR) oral oxycodone when co‐administered with PR naloxone, and its opioid‐induced in patients severe chronic pain. Another objective was to identify optimal dose ratio naloxone. Methods: A total 202 pain (mainly non‐cancer related, 2.5% had cancer‐related pain) under stable therapy (40, 60 or...
This multicenter study compared the relapse and recurrence outcomes of two active treatments, maintenance cognitive-behavioral therapy (CBT) manualized psychoeducation, both in addition to treatment as usual, patients remission from depression. was a prospective randomized observer-blinded with parallel groups. The authors assessed 180 three or more previous major depressive episodes who met criteria over 2-month baseline period were randomly assigned 16 sessions either CBT psychoeducation 8...
Summary Objective To compare the effectiveness of controlled‐released carbamazepine (CR‐CBZ) to levetiracetam (LEV) and lamotrigine (LTG) in elderly patients with newly diagnosed focal epilepsy. Methods Randomized, double‐blind, parallel‐group trial conducted between January 2007 August 2011, 47 ambulatory or hospital sites Germany, Austria, Switzerland. Eligible participants were aged ≥60, had new‐onset epilepsy, no acute illness as cause their seizures, contraindication drugs trial....
To compare the overall survival of patients with hepatocellular carcinoma (HCC) who were treated lipiodol-based conventional transarterial chemoembolization (cTACE) that drug-eluting bead (DEB-TACE). By an electronic search our radiology information system, we identified 674 received TACE between November 2002 and July 2013. A total 520 cTACE, 154 DEB-TACE. In total, 424 excluded for following reasons: tumor type other than HCC (n = 91), liver transplantation after 119), lack histological...
To prospectively compare SIRT and DEB-TACE for treating hepatocellular carcinoma (HCC). From 04/2010–07/2012, 24 patients with histologically proven unresectable N0, M0 HCCs were randomized 1:1 to receive or DEB-TACE. could be repeated once in case of recurrence; while, TACE was every 6 weeks until no viable tumor tissue detected by MRI contraindications prohibited further treatment. Patients followed-up 3 months; the final evaluation 05/2013. Both groups comparable demographics (SIRT:...
Due to public stigma or self-stigma and shame, many adolescents with mental illness (MI) struggle the decision whether disclose their MI others. Both disclosure nondisclosure are associated risks benefits. Honest, Open, Proud (HOP) is a peer-led group program that supports participants decisions in order reduce stigma's impact. Previously, HOP had only been evaluated among adults MI.This two-arm pilot randomized controlled trial included 98 MI. Participants were randomly assigned treatment...
Background: Neurofeedback (NF) in children with attention-deficit/hyperactivity disorder (ADHD) has been investigated a series of studies over the last years. Previous did not unanimously support NF as treatment ADHD. Most control for unspecific effects and demonstrate that self-regulation took place. The present study examined efficacy comparison to electromyographic (EMG) feedback treatment, assessed slow cortical potentials (SCPs). Methods: A total 150 aged 7-9 years diagnosed ADHD (82%...
Summary Background Advanced fibrosis has been established as the most important predictor of overall mortality in patients with non‐alcoholic fatty liver disease ( NAFLD ). In contrast to cirrhosis, advanced, non‐cirrhotic is difficult identify and data from Germany are lacking. Aim To clinical factors associated fibrosis. Methods Patients were recruited prospectively enrolling European Registry. Clinical characteristics performance non‐invasive surrogate scores compared vibration‐controlled...
Objectives Cognitive comorbidity at epilepsy onset reflects disease severity and provides a baseline estimate of reserve capacities with regard to the effects its treatment. Given high incidence an older age, this study analyzed objective subjective cognition as well quality life in elderly patients new-onset focal before initiation anti-epileptic Materials methods A total 257 untreated (60–95 years age) underwent assessment executive function (EpiTrack) performed ratings (Portland...
Medication non-adherence is frequent and associated with high morbidity mortality in patients chronic heart failure (CHF). We investigated whether an interdisciplinary intervention improves adherence elderly CHF patients.The study population (mean age 74 years, 62% male, mean left ventricular ejection fraction 47%, 52% New York Heart Association class III) consisted of 110 randomized into the pharmacy care 127 usual group. The median follow-up was 2.0 years (interquartile range 1.2-2.7)....
Transferring patients with large-vessel occlusion (LVO) or intracranial hemorrhage (ICH) to hospitals not providing interventional treatment options is an unresolved medical problem.To determine how optimized prehospital management (OPM) based on use of the Los Angeles Motor Scale (LAMS) compares in a Mobile Stroke Unit (MSU) accurately triaging appropriate hospital (comprehensive stroke center [CSC]) without (primary [PSC]) treatment.In this randomized multicenter trial 3-month follow-up,...
Summary Background Lifestyle modifications remain the cornerstone of treatment in non‐alcoholic fatty liver disease (NAFLD). However, they requently fail related to inability patients implement lasting changes. Aims To evaluate effects a short, web‐based, individualised exercise program on non‐invasive markers hepatic steatosis, inflammation and fibrosis. Methods Patients with histologically confirmed NAFLD underwent an 8‐week, that contained bidirectional feedback. Results Forty‐four...
To compare the efficacy of slow-release oral morphine (SROM) and methadone as maintenance medication for opioid dependence in patients previously treated with methadone.Prospective, multiple-dose, open label, randomized, non-inferiority, cross-over study over two 11-week periods. Methadone treatment was switched to SROM flexible dosing vice versa according period sequence treatment.Fourteen out-patient addiction centres Switzerland Germany.Adults programmes (dose ≥50 mg/day) ≥26 weeks.The...
OBJECTIVE This study compared the long-term efficacy of a diabetes-specific cognitive behavioral group therapy (CBT) with sertraline in patients diabetes and depression who initially responded to short-term treatment. RESEARCH DESIGN AND METHODS A randomized controlled single-blind trial was conducted 70 secondary care centers across Germany comparing 12 weeks CBT 251 type 1 or 2 (mean HbA1c 9.3%, 78 mmol/mol) major (Structured Clinical Interview for DSM-IV [SCID]). After weeks, treatment...
Abstract Background No results of controlled trials are available for any the few treatments offered to children with interstitial lung diseases (chILD). We evaluated hydroxychloroquine (HCQ) in a phase 2, prospective, multicentre, 1:1-randomized, double-blind, placebo-controlled, parallel-group/crossover trial. HCQ (START arm) or placebo were given 4 weeks. Then all subjects received another In STOP arm already taking randomized 12 weeks (= withdrawal HCQ). stopped treatment and observed...
Abstract Background In the last few years, excessive internet use and computer gaming have increased dramatically. Salience, mood modification, tolerance, withdrawal symptoms, conflict, relapse been defined as diagnostic criteria for addiction (IA) (CA) in scientific community. Despite a growing number of individuals seeking help, there are no specific treatments established efficacy. Methods/design This clinical trial aims to determine effect disorder-specific manualized short-term...