A5008880258- Gastrointestinal motility and disorders
- Pain Management and Opioid Use
- Parkinson's Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- Dental Implant Techniques and Outcomes
- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Opioid Use Disorder Treatment
- Wound Healing and Treatments
- Dental materials and restorations
- Surgical Sutures and Adhesives
- Pharmacology and Obesity Treatment
- Hip and Femur Fractures
- Bone Tissue Engineering Materials
- Bone fractures and treatments
- Archaeological and Historical Studies
- Musculoskeletal pain and rehabilitation
- Gastroesophageal reflux and treatments
- Sleep and Wakefulness Research
- Orthopaedic implants and arthroplasty
- Dental Radiography and Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Intestinal and Peritoneal Adhesions
- Laser Applications in Dentistry and Medicine
- Liver physiology and pathology
University Medical Center of the Johannes Gutenberg University Mainz
2023-2025
Johannes Gutenberg University Mainz
2023-2025
Mundipharma (Germany)
2008-2020
Technische Hochschule Ingolstadt
2019
Tel Aviv University
2014
Universität Greifswald
2003-2014
Purdue Pharma (United States)
2014
Technical University of Munich
2013
Klinikum rechts der Isar
2013
Weatherford College
2009
ABSTRACT Background: Opioid‐induced constipation can have a major negative impact on patients’ quality of life. This randomised, double‐blinded study evaluated the analgesic efficacy prolonged‐release (PR) oral oxycodone when co‐administered with PR naloxone, and its opioid‐induced in patients severe chronic pain. Another objective was to identify optimal dose ratio naloxone. Methods: A total 202 pain (mainly non‐cancer related, 2.5% had cancer‐related pain) under stable therapy (40, 60 or...
Objective: Opioid therapy is frequently associated with treatment-limiting constipation. Naloxone an opioid antagonist low oral systemic bioavailability. This Phase III clinical trial assessed the safety and efficacy of fixed-ratio combination oxycodone prolonged-release (PR) naloxone PR compared in relieving opioid-induced constipation.Study design: double-blind, multicenter was conducted specialist primary care centers four European countries out-patients setting. The study included 322...
This randomised, double-blind, double-dummy, parallel-group multicentre study assessed the impact of a total daily dose 60-80 mg oral oxycodone prolonged-release (PR)/naloxone PR (OXN PR) as fixed-ratio combination for patients with opioid-induced constipation (OIC) having moderate-to-severe, non-malignant pain.During pre-randomisation receiving opioids moderate-to-severe pain were converted to (OXY and titrated an effective analgesic dose. During randomisation 265 on stable OXY (60-80...
Objective: An examination of whether oxycodone/naloxone prolonged-release tablets (OXN PR) can improve constipation and maintain analgesia, compared with oxycodone (OxyPR) in patients moderate/severe cancer pain. Methods: Randomized, double-blind, active-controlled, double-dummy, parallel-group study which 185 were randomized to receive up 120 mg/day OXN PR or OxyPR over 4 weeks. Efficacy assessments included Bowel Function Index (BFI), Brief Pain Inventory Short-Form (BPI-SF), laxative...
The aim of this study was to assess safety and efficacy fixed combination oxycodone prolonged release (PR)/naloxone PR in terms both analgesia improving opioid-induced bowel dysfunction (OIBD) associated symptoms, such as constipation (OIC), adults with chronic non-cancer pain.These were open-label extension studies which patients who had previously completed a 12-week, double-blind received PR/naloxone for up 52 weeks. assessed pain using the modified Brief Pain Inventory-Short Form...
To determine the absolute bioavailability of naloxone from oral doses ranging 5 mg to 120 mg.In this open-label study, 28 healthy subjects received 1 (0.4 mg/ml) as an intravenous infusion (reference treatment), and following prolonged release (PR) tablets: mg, 20 40 80 mg. The pharmacokinetic characteristics administered per rectum were also investigated. Each subject five seven treatments single with a 7 day washout between doses. Pharmacokinetic blood sampling safety monitoring performed...
Abstract A major consideration in designing dental implants is the creation of a surface that provides strong attachment between implant and bone, connective tissue, or epithelium. In addition, it important to inhibit adherence oral bacteria on titanium surfaces exposed cavity maintain plaque‐free implants. Previous vitro studies have shown coated with nitride (TiN) reduced bacterial colonization compared other clinically used surfaces. The aim present study was examine support fibroblast...
Abstract Background Two randomised 12-week, double-blind, parallel-group, multicenter studies comparing oxycodone PR/naloxone PR and alone on symptoms of opioid-induced bowel dysfunction in patients with moderate/severe non-malignant pain have been conducted. Methods These were prospectively designed to be pooled the primary outcome measure data analysis was demonstrate non-inferiority 12-week analgesic efficacy versus alone. Patients constipation switched then fixed doses (n = 292) or 295)...
To evaluate the long-term safety and efficacy of prolonged-release oxycodone/naloxone (OXN PR) its impact on quality life (QoL), in patients with moderate-to-severe cancer pain.This was an open-label extension (OLE) a 4 week, randomized, double-blind (DB) study which pain had been randomized to OXN PR or oxycodone (OxyPR). During OLE phase, were treated capsules (≤ 20/60 mg/day) for ≤ 24 weeks. Outcome measures included safety, QoL.One hundred twenty-eight entered OLE, average scores based...
This study investigates the associations between early childhood adversities, stress perception, and fibromyalgia syndrome (FMS). Although interconnection dysregulated systems FMS is well documented, adversities remains less understood. explores relationship of early-life by examining its mediation through perceived stress, acute chronic endocrine indicators. Stress was assessed using scale, as salivary hair cortisol indicators respectively. The sample consisted 99 individuals with 50...
Atypical Candida strains were isolated from patients in Madagascar, Angola and Germany. These isolates slow growing unable to produce chlamydospores. They had atypical carbohydrate assimilation profiles. All assimilate the amino sugars N-acteylglucosamine glucosamine as well disaccharide trehalose organic acid DL-lactate. germ-tube-positive serum, but only some of these organisms produced pseudohyphae after a long incubation. As shown by Fourier transform infrared spectroscopy clustered...
Background and objectives: Opioid-induced constipation can have a major negative impact on patients' quality of life. This randomised clinical trial evaluated patient assessment the efficacy tolerability oral prolonged-release (PR) oxycodone when co-administered with naloxone PR. Methods: Two hundred two patients chronic cancer- or non-cancer-related pain undergoing stable PR therapy (40, 60 80 mg/day) were to one four intervention groups: 10, 20 40 mg/day placebo. Following 4-week...
Objective:Constipation is a common adverse event of treatment with opioids for chronic non-malignant pain and may result in considerable reduction health-related quality life. The aim this study was to assess the psychometric properties Bowel Function Index (BFI) european patients suffering from constipation secondary opioid analgesic chronic, pain.
This exploratory study in healthy volunteers investigated the effect of single doses oxycodone on gastrointestinal (GI) transit time and degree to which a dose naloxone reverses oxycodone-induced effect.Fifteen male received: 10 and2 0 mg, oxycodone/naloxone 10/5 20/10 mg (all as prolonged release tablets) placebo. Each was radiolabelled administered with capsule containing resin (surrogate for GI contents).Scintigraphic analysis showed that 20 significantly increased colon arrival (mean...
In Brief Local treatment of burn injuries with conventional anti-infective preparations does not provide the moist environment that promotes fast wound healing. a randomized controlled trial effects liposome polyvinyl-pyrrolidone-iodine (PVP-I) hydrogel, novel formulation PVP-I in hydrogel high water-binding capacity, were investigated 43 patients partial-thickness wounds an intraindividual comparison silver-sulfadiazine cream. Treatment resulted significantly faster complete healing...
While opioids provide effective analgesia, opioid-induced constipation (OIC) can severely impact quality of life and treatment compliance. This pooled analysis evaluated the maintenance efficacy safety during long-term with combined oxycodone/naloxone prolonged-release tablets (OXN PR) in adults moderate-to-severe chronic pain.Patients (N = 474) received open-label OXN PR 52-week extension phases two studies, having completed 12-week, double-blind, randomized oxycodone (Oxy or PR. Analgesia...
Abstract Background Oxycodone/naloxone ( OXN PR ) is a prolonged‐release formulation containing oxycodone and naloxone in 2:1 ratio. This study aimed to evaluate the tolerability efficacy of doses up 160/80 mg compared with (Oxy randomised controlled trial. Methods Two hundred forty‐three patients were treatment n = 123) or Oxy 120) during 5‐week double‐blind study. Measured were: opioid‐induced constipation [bowel function index score BFI )]; analgesic NRS 0–10); daily laxative rescue...
Objective To assess the efficacy and safety of modified-release (MR) versus immediate-release (IR) prednisone in newly diagnosed glucocorticoid (GC)-naïve patients with polymyalgia rheumatica (PMR). Methods Patients were randomised to double-blind MR (taken at approximately 22:00) or IR morning), 15 mg/day for 4 weeks. The primary end point was complete response rate (≥70% reduction PMR visual analogue scale, duration morning stiffness C reactive protein (CRP) (or CRP <2× upper limit...