Wolfgang N. Löscher
A5000794291- Peripheral Nerve Disorders
- Peripheral Neuropathies and Disorders
- Neurogenetic and Muscular Disorders Research
- Hereditary Neurological Disorders
- Myasthenia Gravis and Thymoma
- Genetic Neurodegenerative Diseases
- Nerve Injury and Rehabilitation
- Neurological disorders and treatments
- Orthopedic Surgery and Rehabilitation
- Muscle activation and electromyography studies
- Amyotrophic Lateral Sclerosis Research
- Muscle Physiology and Disorders
- Glycogen Storage Diseases and Myoclonus
- Parkinson's Disease Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Botulinum Toxin and Related Neurological Disorders
- Pain Mechanisms and Treatments
- Neurological diseases and metabolism
- Autoimmune Neurological Disorders and Treatments
- Lysosomal Storage Disorders Research
- Cardiomyopathy and Myosin Studies
- Neuroscience and Neural Engineering
- Motor Control and Adaptation
- Inflammatory Myopathies and Dermatomyositis
Innsbruck Medical University
2016-2025
Universität Innsbruck
2015-2025
University Hospital Innsbruck
2002-2024
Essen University Hospital
2024
Ludwig-Maximilians-Universität München
2020-2024
Friedrich Baur Stiftung
2024
SMART Reading
2024
Medical University of Vienna
1999-2020
Polish Academy of Sciences
2020
Dr. John T. Macdonald Foundation
2020
To improve accuracy in the diagnosis of carpal tunnel syndrome (CTS) by comparing cross-sectional area (CSA) measurements median nerve obtained at level (CSAc) with those more proximally (CSAp), pronator quadratus muscle.The study protocol was approved institutional review board, and all subjects gave written informed consent. One hundred wrists 68 consecutive patients CTS (16 men, 52 women; mean age, 57.9 years; range, 25-85 years) 93 58 healthy volunteers male, 42 female; 55.1 17-85 were...
<h3>Importance</h3> Intravenous edaravone is approved as a disease-modifying drug for patients with amyotrophic lateral sclerosis (ALS), but evidence efficacy limited to short-term beneficial effects shown in the MCI186-ALS19 study subpopulation which was expected. <h3>Objective</h3> To evaluate long-term safety and effectiveness of intravenous therapy ALS real-world clinical setting. <h3>Design, Setting, Participants</h3> Multicenter, propensity score–matched cohort conducted between June...
Neurological sequelae from coronavirus disease 2019 (COVID-19) may persist after recovery acute infection. Here, the aim was to describe natural history of neurological manifestations over 1 year COVID-19.A prospective, multicentre, longitudinal cohort study in COVID-19 survivors performed. At a 3-month and 1-year follow-up, patients were assessed for impairments by examination standardized test battery including assessment hyposmia (16-item Sniffin' Sticks test), cognitive deficits...
Evidence for the efficacy of nusinersen in adults with 5q-associated spinal muscular atrophy (SMA) has been demonstrated up to a period 16 months relatively large cohorts but whereas patients reach plateau over time is still be demonstrated. We investigated and safety SMA 38 months, longest date cohort from multiple clinical sites. Our prospective, observational study included adult Germany, Switzerland, Austria (July 2017 May 2022). All participants had genetically-confirmed, were treated...
Several hundred genetic muscle diseases have been described, all of which are rare. Their clinical and heterogeneity means that a diagnosis is challenging. We established an international consortium, MYO-SEQ, to aid the work-ups disease patients better understand etiology.Exome sequencing was applied 1001 undiagnosed recruited from more than 40 neuromuscular referral centers; standardized phenotypic information collected for each patient. Exomes were examined variants in 429 genes associated...
Abstract Previous studies have described the clinical, serological and pathological features of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) antibodies directed against paranodal proteins neurofascin-155, contactin-1 (CNTN1), contactin-associated protein-1 (Caspr1), or nodal forms neurofascin. Such are useful for diagnosis potentially treatment selection. However, targeting Caspr1 only Caspr1/CNTN1 complex been reported in few CIDP. Moreover, it is unclear...
Cardiac troponin (cTn) T and cTnI are considered cardiac specific equivalent in the diagnosis of acute myocardial infarction. Previous studies suggested rare skeletal myopathies as a noncardiac source cTnT. We aimed to confirm reliability/cardiac specificity cTnT patients with various muscle disorders (SMDs).We prospectively enrolled presenting muscular complaints (≥2 weeks) for elective evaluation 4 hospitals 2 countries. After workup, were adjudicated into 3 predefined disease categories....
Abstract 5q-associated spinal muscular atrophy is a rare neuromuscular disorder with the leading symptom of proximal muscle weakness. Three different drugs have been approved by European Medicines Agency and Food Drug Administration for treatment patients, however, long-term experience still scarce. In contrast to clinical trial data restricted patient populations short observation periods, we report here real-world evidence on broad spectrum patients early-onset treated nusinersen focusing...
Abstract In digenic inheritance, pathogenic variants in two genes must be inherited together to cause disease. Only very few examples of inheritance have been described the neuromuscular disease field. Here we show that predicted deleterious SRPK3 , encoding X-linked serine/argenine protein kinase 3, lead a progressive early onset skeletal muscle myopathy only when combination with heterozygous TTN gene. The co-occurrence / was not seen among 76,702 healthy male individuals, and statistical...
To assess the performance of serum neurofilament light chain (sNfL) in clinical phenotypes amyotrophic lateral sclerosis (ALS).
Abstract To determine magnetic resonance imaging (MRI) patterns of brain atrophy in parkinsonian syndromes, we applied voxel‐based morphometry (VBM) to segmented gray matter, white and cerebrospinal fluid compartments T 1 ‐weighted volumes 12 patients with probable multiple system atrophy–parkinson variant (MSA‐P) Parkinson's disease patients, comparing them normal controls matched for age. In comparison controls, a cortical pattern was observed MSA‐P significant clusters volume loss primary...
1. This study was undertaken to examine changes of excitatory drive the triceps surae alpha‐motoneuron pool during fatiguing submaximal isometric contractions in man. Eight healthy subjects maintained plantar flexions at 30 percent maximum voluntary contraction (MVC) until limit endurance (range, 6‐9 min). 2. Excitability Ia afferent stimulation (H reflex), electromyograms (EMG) and compound motor unit action potentials (Mmax) from lateral (LG) medial heads (MG) gastrocnemius as well soleus...
To evaluate the accuracy of ultrasonography (US) in diagnosis carpal tunnel syndrome (CTS) patients with a bifid median nerve on basis cross-sectional area (CSA) measurements at level (CSAc), additional obtained more proximally (CSAp) pronator quadratus muscle.This HIPAA-compliant study was approved by local institutional review board; informed oral and written consent were obtained. Fifty-three wrists 49 consecutive CTS symptoms 28 27 healthy volunteers examined using US. Two independent US...
Abstract The phase III double-blind PROPEL study compared the novel two-component therapy cipaglucosidase alfa + miglustat (cipa mig) with alglucosidase placebo (alg pbo) in adults late-onset Pompe disease (LOPD). This ongoing open-label extension (OLE; NCT04138277) evaluates long-term safety and efficacy of cipa mig. Outcomes include 6-min walk distance (6MWD), forced vital capacity (FVC), creatine kinase (CK) hexose tetrasaccharide (Hex4) levels, patient-reported outcomes safety. Data are...
Defects of mitochondrial polymerase γ (POLG) underlie neurological diseases ranging from myopathies to parkinsonism and infantile Alpers syndrome. The most severe manifestations have been associated with mutations the 'spacer' region POLG, function which has remained unstudied in humans. We identified a family, segregating three POLG amino acid variants, A467T, R627Q Q1236H. first two affect spacer third is polymorphism, allelic R627Q. Three grades disease severity appeared correlate...